Review
Version 1
This version is not peer-reviewed
Mathematical Models for FDG Kinetics in Cancer: A Review
Version 1
: Received: 27 June 2021 / Approved: 29 June 2021 / Online: 29 June 2021 (08:34:49 CEST)
A peer-reviewed article of this Preprint also exists.
Sommariva, S.; Caviglia, G.; Sambuceti, G.; Piana, M. Mathematical Models for FDG Kinetics in Cancer: A Review. Metabolites 2021, 11, 519. Sommariva, S.; Caviglia, G.; Sambuceti, G.; Piana, M. Mathematical Models for FDG Kinetics in Cancer: A Review. Metabolites 2021, 11, 519.
Abstract
Compartmental analysis is the mathematical framework for the modelling of tracer kinetics in dynamical Positron Emission Tomography. This paper provides a review of how compartmental models are constructed and numerically optimized. Specific focus is given on the identifiability and sensitivity issues and on the impact of complex physiological conditions on the mathematical properties of the models.
Keywords
Positron Emission Tomography (PET); FDG; tracer kinetics; compartmental analysis
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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