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Nitric Oxide as a Determinant of Human Longevity and Health Span
Version 1
: Received: 1 September 2023 / Approved: 4 September 2023 / Online: 6 September 2023 (14:47:08 CEST)
A peer-reviewed article of this Preprint also exists.
Poeggeler, B.; Singh, S.K.; Sambamurti, K.; Pappolla, M.A. Nitric Oxide as a Determinant of Human Longevity and Health Span. Int. J. Mol. Sci. 2023, 24, 14533. Poeggeler, B.; Singh, S.K.; Sambamurti, K.; Pappolla, M.A. Nitric Oxide as a Determinant of Human Longevity and Health Span. Int. J. Mol. Sci. 2023, 24, 14533.
Abstract
The master molecular regulators and mechanisms determining longevity and health span include nitric oxide (NO) and superoxide anion radicals (SOR). L-arginine, the NO synthase (NOS) substrate, can restore a healthy ratio between the dangerous SOR and the protective NO radical to promote healthy aging. Antioxidant supplementation orchestrates protection against oxidative stress and damage—L-arginine and antioxidants such as vitamin C increase NO production and bioavailability. Uncoupling of NO generation with the appearance of SOR can be induced by asymmetric dimethylarginine (ADMA). L-arginine can displace ADMA from the site of NO formation if sufficient amounts of the amino acid are available. Antioxidants such as ascorbic acids can scavenge SOR and increase the bioavailability of NO. The topics of this review are the complex interactions of antioxidant agents with L-arginine, which determine NO bioactivity and protection against age-related degeneration.
Keywords
aging; amino acids; antioxidant; arginine; nitric oxide; oxidative stress; protein; peptide
Subject
Biology and Life Sciences, Aging
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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