Version 1
: Received: 5 March 2024 / Approved: 5 March 2024 / Online: 5 March 2024 (12:44:31 CET)
Version 2
: Received: 2 April 2024 / Approved: 2 April 2024 / Online: 3 April 2024 (16:38:00 CEST)
Chen, L.; Chen, G.; Gai, T.; Zhou, X.; Zhu, J.; Wang, R.; Wang, X.; Guo, Y.; Wang, Y.; Xie, Z. L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans. Molecules2024, 29, 2691.
Chen, L.; Chen, G.; Gai, T.; Zhou, X.; Zhu, J.; Wang, R.; Wang, X.; Guo, Y.; Wang, Y.; Xie, Z. L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans. Molecules 2024, 29, 2691.
Chen, L.; Chen, G.; Gai, T.; Zhou, X.; Zhu, J.; Wang, R.; Wang, X.; Guo, Y.; Wang, Y.; Xie, Z. L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans. Molecules2024, 29, 2691.
Chen, L.; Chen, G.; Gai, T.; Zhou, X.; Zhu, J.; Wang, R.; Wang, X.; Guo, Y.; Wang, Y.; Xie, Z. L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans. Molecules 2024, 29, 2691.
Abstract
L-Theanine, a unique non-protein amino acid, is an important bioactive component of green tea. Previous studies have shown that L-theanine has many potent health benefits, such as anti-anxiety effect, regulation of immune response, relaxing neural tension, reducing oxidative damage. However, little is known concerning whether L-theanine can improve the clearance of mitochondrial DNA (mtDNA) damage in organisms. Here, we reported that L-theanine treatment increased ATP production and improved mitochondrial morphology to extend the lifespan of UVC-exposed nematodes. Mechanistic investigations showed that L-theanine treatment enhanced the removal of mtDNA damage and extended lifespan by activating autophagy, mitophagy, mitochondrial dynamics, and mitochondrial unfolded protein response (UPRmt) in UVC-exposed nematodes. In addition, L-theanine treatment also up-regulated the expression of genes related to mitochondrial energy metabolism in UVC-exposed nematodes. Our study provided a theoretical basis for the possibility that tea drinking may prevent mitochondrial related diseases.
Keywords
L-theanine; UVC; mitochondrial DNA damage; C. elegans; lifespan
Subject
Medicine and Pharmacology, Other
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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