Review
Version 1
Preserved in Portico This version is not peer-reviewed
Xanthone Derivatives for Potential Use in Topical Treatment of Telangiectasia and Rosacea
Version 1
: Received: 7 March 2024 / Approved: 8 March 2024 / Online: 8 March 2024 (06:25:27 CET)
A peer-reviewed article of this Preprint also exists.
Brezdeń, K.; Waszkielewicz, A.M. Xanthone Derivatives and Their Potential Usage in the Treatment of Telangiectasia and Rosacea. Appl. Sci. 2024, 14, 4037. Brezdeń, K.; Waszkielewicz, A.M. Xanthone Derivatives and Their Potential Usage in the Treatment of Telangiectasia and Rosacea. Appl. Sci. 2024, 14, 4037.
Abstract
Xanthone derivatives, a class of natural compounds abundantly found in plants such as mangosteen (Garcinia mangostana) and certain herbs, have garnered substantial interest due to their diverse pharmacological properties, including antioxidant, anti-inflammatory, and anti-cancer activities. Recent investigations have unveiled their potential as modulators of enzymatic activity, prompting exploration into their effects on hyaluronidase-mediated HA degradation, and their effects in topical treatment of telangiectasia and rosacea. Telangiectasia and rosacea are common dermatological conditions characterized by chronic skin inflammation, vascular abnormalities, and visible blood vessels, resulting in significant cosmetic concerns and impaired quality of life for affected individuals. This review aims to provide a comprehensive overview of the current understanding regarding the interplay between mechanisms of action by which xanthone derivatives exert their therapeutic effects, including the inhibition of pro-inflammatory cytokines, modulation of oxidative stress pathways, and regulation of vascular endothelial growth factors. Furthermore, we will discuss the implications of harnessing xanthone derivatives as therapeutic agents for mitigating vascular dysfunction and its associated pathologies, thereby offering insights into future research directions and therapeutic strategies in the field of vascular biology.
Keywords
xanthone, telangiectasia, rosacea, vascular disorders, cosmetics, dermatology, blood vessels
Subject
Medicine and Pharmacology, Dermatology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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