Version 1
: Received: 11 May 2024 / Approved: 11 May 2024 / Online: 13 May 2024 (12:14:58 CEST)
How to cite:
Lin, Y.; Chen, X.; Wang, K.; Liang, L.; Zhang, H. An Overview of Nanoparticle-Based Delivery Platforms for Vaccines. Preprints2024, 2024050738. https://doi.org/10.20944/preprints202405.0738.v1
Lin, Y.; Chen, X.; Wang, K.; Liang, L.; Zhang, H. An Overview of Nanoparticle-Based Delivery Platforms for Vaccines. Preprints 2024, 2024050738. https://doi.org/10.20944/preprints202405.0738.v1
Lin, Y.; Chen, X.; Wang, K.; Liang, L.; Zhang, H. An Overview of Nanoparticle-Based Delivery Platforms for Vaccines. Preprints2024, 2024050738. https://doi.org/10.20944/preprints202405.0738.v1
APA Style
Lin, Y., Chen, X., Wang, K., Liang, L., & Zhang, H. (2024). An Overview of Nanoparticle-Based Delivery Platforms for Vaccines. Preprints. https://doi.org/10.20944/preprints202405.0738.v1
Chicago/Turabian Style
Lin, Y., Li Liang and Hongxia Zhang. 2024 "An Overview of Nanoparticle-Based Delivery Platforms for Vaccines" Preprints. https://doi.org/10.20944/preprints202405.0738.v1
Abstract
With its unique properties and potential applications, nanoparticle-based delivery platforms for vac-cines have gained significant attention in recent years. Nanoparticles have the advantages of enhancing immunogenicity, targeting delivery and improving stability, providing a new solution for drug and vaccine delivery. And in some clinical studies, a variety of nanoparticle delivery platforms have been gradually applied to a wide range of vaccine applications. Current research priorities are exploring various types of nanoparticles as vaccine delivery system to enhance vaccine stability and immunogen-icity. Lipid nanoparticles have shown promising potential in preclinical and clinical studies to efficiently deliver antigens to immune cells. Moreover, lipid nanoparticles (LNPs) and other nanoparticles as nu-cleic acids especially mRNA delivery system, have shown vast potential for vaccine development. In this review, we present various vaccine platforms with an emphasis on nanoparticles for mRNA nano-vaccine delivery vehicles. We introduce several novel nanoparticles delivery platforms for mRNA vac-cine such as lipid, polymer, protein-based nanoparticle and so on. In addition, we overview the an-ti-tumor immunity of nanovaccine against different tumors in cancer immunotherapy. Finally, we give an outlook future perspectives and remaining challenges for this promising technolo-gy-nanoparticle-based delivery platforms for vaccines.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
