Review
Version 1
Preserved in Portico This version is not peer-reviewed
The Initiation of Th2 Immunity towards Food Allergens
Version 1
: Received: 3 April 2018 / Approved: 4 April 2018 / Online: 4 April 2018 (07:35:35 CEST)
A peer-reviewed article of this Preprint also exists.
Ellenbogen, Y.; Jiménez-Saiz, R.; Spill, P.; Chu, D.K.; Waserman, S.; Jordana, M. The Initiation of Th2 Immunity Towards Food Allergens. Int. J. Mol. Sci. 2018, 19, 1447. Ellenbogen, Y.; Jiménez-Saiz, R.; Spill, P.; Chu, D.K.; Waserman, S.; Jordana, M. The Initiation of Th2 Immunity Towards Food Allergens. Int. J. Mol. Sci. 2018, 19, 1447.
Abstract
In contrast to Th1 immune responses against pathogenic viruses and bacteria, the incipient events that generate Th2 responses remain less understood. Part of the difficulty in identifying universal operating principles stems from the diversity of entities against which cellular and molecular Th2 responses are produced. Indeed, such responses are launched towards harmful macroscopic parasites and noxious substances such as venoms but also against largely innocuous allergens. This suggests that the canonical understanding about sensing and recognition applied to Th1 responses may not be translatable to Th2 responses. This review will discuss processes and signals known to occur in Th2 responses, particularly in the context of food allergy. We propose that perturbations of homeostasis at barrier sites induced by external or internal subverters that either activate the immune system or lower its threshold activation are the major requirement for allergic sensitization. Innate signals produced in the tissue under these conditions equip dendritic cells with a program that shapes an adaptive Th2 response.
Keywords
Th2 immunity; food allergy; allergic sensitization; allergens; alarmins; initiation of allergy; IgE; allergic disease
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (3)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
Commenter: Karanbir Brar
The commenter has declared there is no conflict of interests.
The commenter has declared there is no conflict of interests.
The commenter has declared there is no conflict of interests.