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  title = {{BioMuta} and {BioXpress}: mutation and expression knowledgebases for cancer biomarker discovery},
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}


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}




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}



@article{Aidoo2002,
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    journal = {Hematology Reports}
}






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number={1}, 
journal={Clinical Hemorheology and Microcirculation}, 
publisher={IOS Press}, 
author={Kobina Dufu and Mira Patel and Donna Oksenberg and Pedro Cabrales}, 
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	title = {A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells},
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}

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}



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}
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	title = {Extensive Bone Marrow Necrosis: Initial Presentation in Sickle Cell Anemia{\textemdash}A Case Report and Review of the Literature},
	journal = {Case Reports in Hematology}
}

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}

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}

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}

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}

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 author = {Donna Oksenberg and Kobina Dufu and Mira P. Patel and Chihyuan Chuang and Zhe Li and Qing Xu and Abel Silva-Garcia and Chengjing Zhou and Athiwat Hutchaleelaha and Larysa Patskovska and Yury Patskovsky and Steven C. Almo and Uma Sinha and Brian W. Metcalf and David R. Archer},
 title = {{GBT}440 increases haemoglobin oxygen affinity, reduces sickling and prolongs {RBC} half-life in a murine model of sickle cell disease},
 journal = {British Journal of Haematology}
}



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}



@book{marsh2013handbook,

 title={{Handbook of lipid bilayers}},

 author={Marsh, Derek},

 year={2013},

 publisher={CRC Press}

}


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 author = {Hong-yuan Luo and Adeboye H. Adewoye and Shawn H. Eung and Timothy P. Skelton and Karen Quillen and Lillian McMahon and Martin H. Steinberg and David H. K. Chui},
 title = {A Novel Sickle Hemoglobin: Hemoglobin {S}-South End},
 journal = {Journal of Pediatric Hematology/Oncology}
}








@Article{Steinberg2006,
author="Steinberg, Martin H.",
title="Pathophysiologically based drug treatment of sickle cell disease.",
journal="Trends in pharmacological sciences",
year="2006",
month="Apr",
day="13",
volume="27",
number="4",
pages="204-210",
keywords="Anemia, Sickle Cell",
keywords="Animals",
keywords="Anti-Inflammatory Agents",
keywords="Antisickling Agents",
keywords="Azacitidine",
keywords="Cell Adhesion",
keywords="Drug Therapy, Combination",
keywords="Endothelium, Vascular",
keywords="Erythrocytes",
keywords="Fetal Hemoglobin",
keywords="Gene Expression Regulation",
keywords="Hemoglobin, Sickle",
keywords="Humans",
keywords="Hydroxyurea",
keywords="Pyrrolidonecarboxylic Acid",
keywords="Randomized Controlled Trials as Topic",
keywords="Symporters",
abstract="Sickle cell disease is a systemic disorder that is caused by a mutation (Glu6Val) in the gene that encodes beta globin. The sickle hemoglobin molecule (HbS) is a tetramer of two alpha-globin chains and two sickle beta-globin chains, and has the tendency to polymerize when deoxygenated. HbS facilitates abnormal interactions between the sickle erythrocyte and leukocytes and endothelial cells, which trigger a complex pathobiology. This multifaceted pathophysiology provides the opportunity to interrupt the disease at multiple sites, including polymerization of HbS, erythrocyte density and cell-cell interactions. For example, it is possible to induce higher concentrations of fetal hemoglobin, which disrupts the pathology-initiating step of HbS polymerization. Furthermore, it is possible to improve the hydration of sickle erythrocytes and it might be feasible to counteract the endothelial, inflammatory and oxidative abnormalities of sickle cell disease. A therapeutic approach that targets several sites of pathobiology might be most promising.",
issn="0165-6147",
doi="10.1016/j.tips.2006.02.007",
language="eng"
}











@Article{Akl2009,
author="Akl, Pascale S.
and Kutlar, Ferdane
and Patel, Niren
and Salisbury, Catherine L.
and Lane, Peter
and Young, Andrew N.",
title="Compound heterozygosity for hemoglobin {S} [{beta6(A3)Glu6Val}] and hemoglobin {Korle-Bu} [beta73{(E17)Asp73Asn}].",
journal="Laboratory hematology : official publication of the International Society for Laboratory Hematology",
year="2009",
volume="15",
number="3",
pages="20-24",
keywords="African Americans",
keywords="Blood Cell Count",
keywords="Child, Preschool",
keywords="Chromatography, High Pressure Liquid",
keywords="Codon",
keywords="Diagnosis, Differential",
keywords="Electrophoresis",
keywords="Female",
keywords="Genetic Carrier Screening",
keywords="Hemoglobin, Sickle",
keywords="Hemoglobinopathies",
keywords="Hemoglobins, Abnormal",
keywords="Humans",
keywords="Models, Molecular",
keywords="Phenotype",
keywords="Polymerase Chain Reaction",
keywords="Sequence Analysis, Protein",
keywords="beta-Globins",
abstract="We report a case of compound heterozygous hemoglobins S [beta6(A3)Glu6Val] and Korle-Bu [beta73(E17)Asp73Asn] in a 2-year-old girl. This hemoglobin genotype is associated with a benign clinical course, much like the sickle cell trait; however, its laboratory characteristics are very similar to compound heterozygous hemoglobin S and hemoglobin D-Los Angeles [beta121(GH4)Glu121Gln], which produces severe sickling hemolytic anemia. We describe laboratory data used to resolve this important differential diagnosis and review the interactions between hemoglobin S and the variant hemoglobins that may account for the different clinical phenotypes in compound heterozygotes.",
issn="1523-6528",
doi="10.1532/LH96.09004",
language="eng"
}





















@Article{Kutlar2010,
author="Kutlar, Ferdane
and Redding-Lallinger, R.
and Meiler, S. E.
and Bakanay, S. M.
and Borders, L.
and Kutlar, A.",
title="A new sickling variant 'Hb S-Wake $\beta$[(Glu6Val-Asn139 Ser)]' found in a compound heterozygote with Hb S $\beta$(Glu6Val) coinherited with homozygous $\alpha$-thalassemia-2: phenotype and molecular characteristics.",
journal="Acta haematologica",
year="2010",
month="Sep",
day="23",
volume="124",
number="2",
pages="120-124",
keywords="Adolescent",
keywords="Anemia, Sickle Cell",
keywords="Base Sequence",
keywords="Genetic Variation",
keywords="Hemoglobin, Sickle",
keywords="Heterozygote",
keywords="Homozygote",
keywords="Humans",
keywords="Male",
keywords="Phenotype",
keywords="Protein Structure, Tertiary",
keywords="alpha-Thalassemia",
abstract="We report the case of a 14-year-old African-American boy who was diagnosed with sickle cell disease. Laboratory tests showed that the patient was a compound heterozygote for a novel Hb variant with a double mutation detected on $\beta$(S) allele, Hb S $\beta$Glu6Val, and $\beta$Asn139Ser substitution, i.e. a $\beta$-chain variant named 'Hb S-Wake'. The patient also carried a single Hb S mutation in trans allele, leading to Hb SS-Wake disease. He had coinherited homozygous $\alpha$(+)-thalassemia (-$\alpha$(3.7)/-$\alpha$(3.7)) simultaneously which resulted in multiple globin gene abnormalities.",
issn="1421-9662",
doi="10.1159/000318737",
language="eng"
}











@Article{Dworkis2011,
author="Dworkis, Daniel A.
and Klings, Elizabeth S.
and Solovieff, Nadia
and Li, Guihua
and Milton, Jacqueline N.
and Hartley, Stephen W.
and Melista, Efthymia
and Parente, Jason
and Sebastiani, Paola
and Steinberg, Martin H.
and Baldwin, Clinton T.",
title="Severe sickle cell anemia is associated with increased plasma levels of TNF-R1 and VCAM-1.",
journal="American journal of hematology",
year="2011",
month="Feb",
volume="86",
number="2",
pages="220-223",
keywords="Adult",
keywords="Anemia, Sickle Cell",
keywords="Biomarkers",
keywords="Female",
keywords="Genome-Wide Association Study",
keywords="Guanine Nucleotide Exchange Factors",
keywords="Humans",
keywords="Introns",
keywords="Male",
keywords="Polymorphism, Single Nucleotide",
keywords="Promoter Regions, Genetic",
keywords="Receptors, Tumor Necrosis Factor, Type I",
keywords="Severity of Illness Index",
keywords="United States",
keywords="Vascular Cell Adhesion Molecule-1",
abstract="Sickle cell anemia (SCA, HBB glu6val) is characterized by multiple complications and a high degree of phenotypic variability: some subjects have only sporadic pain crises and few acute hospitalizations, while others experience multiple serious complications, high levels of morbidity, and accelerated mortality [1]. The tumor necrosis factor-$\alpha$ (TNF-$\alpha$) signaling pathway plays important roles in inflammation and the immune response; variation in this pathway might be expected to modify the overall severity of SCA through the pathway's effects on the vascular endothelium [2,3]. We examined plasma biomarkers of TNF-$\alpha$ activity and endothelial cell activation for associations with SCA severity in 24 adults (12 mild, 12 severe). Two biomarkers, tumor necrosis factor-$\alpha$ receptor-1 (TNF-R1) and vascular cell adhesion molecule-1 (VCAM-1) were significantly higher in subjects with severe SCA. Along with these biomarker differences, we also examined data from a genome-wide association study (GWAS) using SCA severity as a disease phenotype, and found evidence of genetic association between disease severity and a single nucleotide polymorphism (SNP) in VCAM1, which codes for VCAM-1, and several SNPs in ARFGEF2, a gene involved in TNF-R1 release [4].",
issn="1096-8652",
doi="10.1002/ajh.21928",
language="eng"
}











@Article{Jorge2012,
author="Jorge, Susan E. D. C.
and Petruk, Ariel A.
and Kimura, Elza M.
and Oliveira, Denise M.
and Caire, Lucas
and Suemasu, Cintia N.
and Silveira, Paulo A. A.
and Albuquerque, Dulcineia M.
and Costa, Fernando F.
and Skaf, Munir S.
and Mart{\'i}nez, Leandro
and Sonati, Maria de Fatima",
title="Hb {S-S{\~a}o Paulo}: a new sickling hemoglobin with stable polymers and decreased oxygen affinity.",
journal="Archives of biochemistry and biophysics",
year="2012",
month="Mar",
day="01",
volume="519",
number="1",
pages="23-31",
keywords="Amino Acid Substitution",
keywords="Anemia, Sickle Cell",
keywords="Base Sequence",
keywords="Chromatography, High Pressure Liquid",
keywords="Electrophoresis",
keywords="Hemoglobin, Sickle",
keywords="Heterozygote",
keywords="Humans",
keywords="Infant",
keywords="Isoelectric Focusing",
keywords="Male",
keywords="Molecular Dynamics Simulation",
keywords="Molecular Sequence Data",
keywords="Oxygen",
keywords="Polymers",
keywords="Protein Stability",
keywords="Solubility",
keywords="Static Electricity",
keywords="beta-Globins",
abstract="Hb S-S{\~a}o Paulo (SP) [HBB:c.20A>T p.Glu6Val; c.196A>G p.Lys65Glu] is a new double-mutant hemoglobin that was found in heterozygosis in an 18-month-old Brazilian male with moderate anemia. It behaves like Hb S in acid electrophoresis, isoelectric focusing and solubility testing but shows different behavior in alkaline electrophoresis, cation-exchange HPLC and RP-HPLC. The variant is slightly unstable, showed reduced oxygen affinity and also appeared to form polymers more stable than the Hb S. Molecular dynamics simulation suggests that the polymerization is favored by interfacial electrostatic interactions. This provides a plausible explanation for some of the reported experimental observations.",
issn="1096-0384",
doi="10.1016/j.abb.2012.01.001",
language="eng"
}











@Article{Mnika2016,
author="Mnika, Khuthala
and Pule, Gift D.
and Dandara, Collet
and Wonkam, Ambroise",
title="An Expert Review of Pharmacogenomics of Sickle Cell Disease Therapeutics: Not Yet Ready for Global Precision Medicine.",
journal="Omics : a journal of integrative biology",
year="2016",
month="Oct",
day="16",
volume="20",
number="10",
pages="565-574",
keywords="Analgesics",
keywords="Analgesics, Opioid",
keywords="Anemia, Sickle Cell",
keywords="Humans",
keywords="Hydroxyurea",
keywords="Pain",
keywords="Pain Management",
keywords="Pharmacogenetics",
keywords="Pharmacogenomic Variants",
keywords="Precision Medicine",
abstract="Sickle cell disease (SCD) is a blood disease caused by a single nucleotide substitution (T > A) in the beta globin gene on chromosome 11. The single point mutation (Glu6Val) promotes polymerization of hemoglobin S (HbS) and causes sickling of erythrocytes. Vaso-occlusive painful crises are associated with recurrent and long-term use of analgesics/opioids and hydroxyurea (HU) by people living with SCD. The present analysis offers a state-of-the-art expert review of the effectiveness of pharmacogenomics/genetics of pain management in SCD, with specific focus on HU and opioids. The literature search used the following keywords: SCD, pharmacogenomics, pharmacogenetics, pain, antalgics, opioids, morphine, and HU. The literature was scanned until March 2016, with specific inclusion of targeted landmark and background articles on SCD. Surprisingly, our review identified only a limited number of studies that addressed the genetic/genomic basis of variable responses to pain (e.g., variants in OPRM1, HMOX-1, GCH1, VEGFA COMT genes), and pharmacogenomics of antalgics and opioids (e.g., variants in OPRM1, STAT6, ABCB1, and COMT genes) in SCD. There has been greater progress made toward identifying the key genomic variants, mainly in BCL11A, HBS1L-MYB, or SAR1, which contribute to response to HU treatment. However, the complete picture on pharmacogenomic determinants of the above therapeutic phenotypes remains elusive. Strikingly, no study has been conducted in sub-Saharan Africa where majority of the patients with SCD live. This alerts the broader global life sciences community toward the existing disparities in optimal and ethical targeting of research and innovation investments for SCD specifically and precision medicine and pharmacology research broadly.",
issn="1557-8100",
doi="10.1089/omi.2016.0105",
language="eng"
}











@Article{Dever2016,
author="Dever, Daniel P.
and Bak, Rasmus O.
and Reinisch, Andreas
and Camarena, Joab
and Washington, Gabriel
and Nicolas, Carmencita E.
and Pavel-Dinu, Mara
and Saxena, Nivi
and Wilkens, Alec B.
and Mantri, Sruthi
and Uchida, Nobuko
and Hendel, Ayal
and Narla, Anupama
and Majeti, Ravindra
and Weinberg, Kenneth I.
and Porteus, Matthew H.",
title="CRISPR/Cas9 $\beta$-globin gene targeting in human haematopoietic stem cells.",
journal="Nature",
year="2016",
month="Nov",
day="17",
volume="539",
number="7629",
pages="384-389",
keywords="Alleles",
keywords="Anemia, Sickle Cell",
keywords="Animals",
keywords="Antigens, CD34",
keywords="CRISPR-Associated Proteins",
keywords="CRISPR-Cas Systems",
keywords="Cell Differentiation",
keywords="Cell Lineage",
keywords="Cell Separation",
keywords="Dependovirus",
keywords="Erythrocytes",
keywords="Female",
keywords="Flow Cytometry",
keywords="Gene Editing",
keywords="Gene Targeting",
keywords="Genes, Reporter",
keywords="Genetic Therapy",
keywords="Hematopoietic Stem Cells",
keywords="Homologous Recombination",
keywords="Humans",
keywords="Magnets",
keywords="Mice, Inbred NOD",
keywords="Mice, SCID",
keywords="Microspheres",
keywords="Mutation",
keywords="RNA, Messenger",
keywords="beta-Globins",
keywords="beta-Thalassemia",
abstract="The $\beta$-haemoglobinopathies, such as sickle cell disease and $\beta$-thalassaemia, are caused by mutations in the $\beta$-globin (HBB) gene and affect millions of people worldwide. Ex vivo gene correction in patient-derived haematopoietic stem cells followed by autologous transplantation could be used to cure $\beta$-haemoglobinopathies. Here we present a CRISPR/Cas9 gene-editing system that combines Cas9 ribonucleoproteins and adeno-associated viral vector delivery of a homologous donor to achieve homologous recombination at the HBB gene in haematopoietic stem cells. Notably, we devise an enrichment model to purify a population of haematopoietic stem and progenitor cells with more than 90\% targeted integration. We also show efficient correction of the Glu6Val mutation responsible for sickle cell disease by using patient-derived stem and progenitor cells that, after differentiation into erythrocytes, express adult $\beta$-globin (HbA) messenger RNA, which confirms intact transcriptional regulation of edited HBB alleles. Collectively, these preclinical studies outline a CRISPR-based methodology for targeting haematopoietic stem cells by homologous recombination at the HBB locus to advance the development of next-generation therapies for $\beta$-haemoglobinopathies.",
issn="1476-4687",
doi="10.1038/nature20134",
language="eng"
}














@article{LIWEI2018,
 year = {2018},
 month = {aug},
 author = {Wei Li},
 title = {NMR-Observed Atomic Bond Length Stability Supports a Dimensionality Shift in Protein Main Chain 3D Structure Description and Representation.},
 journal = {Current Research Bioorganic Organic Chemistry}
}



@article{ZhangR2018,
 author = {Yi, H., Zhang, R.},
 title = {Structures of 7S mutant complexes.},
 journal = {TO BE PUBLISHED, URL: http://www.rcsb.org/structure/5XJQ}
}



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 journal = {Nature}
}


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 author = {Wei Li},
 title = {Simplifying the management of scientific reference and citation with a minimalist {DOI}-{BibTex}-{LaTeX} approach},
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}


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}
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 title = {Highly Selective Stable Isotope Labeling of Histidine Residues by Using a Novel Precursor in E.{\hspace{0.25em}}coli
		-Based Overexpression Systems},
 journal = {{ChemBioChem}}
}
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}
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 journal = {Journal of the American Chemical Society}
}
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 title = {A Histidine/Tryptophan \textpi-Stacking Interaction Stabilizes the Heme-Independent Folding Core of Microsomal Apocytochrome b5 Relative to that of Mitochondrial Apocytochrome b5},
 journal = {Biochemistry}
}

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 journal = {The Journal of Physiology}
}

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 journal = {Nature}
}

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 title={The pH paradox in ischemia-reperfusion injury to cardiac myocytes},
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 journal = {Science}
}


@article{Buja2005,
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 title = {Myocardial ischemia and reperfusion injury},
 journal = {Cardiovascular Pathology}
}
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 title = {Myocardial ischemia-reperfusion injury: a neglected therapeutic target},
 journal = {Journal of Clinical Investigation}
}%JCI62874.pdf


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 author = {Derek M. Yellon and Derek J. Hausenloy},
 title = {Myocardial Reperfusion Injury},
 journal = {New England Journal of Medicine}
}


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 publisher = {Wiley-Blackwell},
 volume = {13},
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 title = {Calcium Channel Blockers},
 journal = {The Journal of Clinical Hypertension}
}

@article{Jafri2015,
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 pages = {203-214},
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 title = {Calcium sparks in the heart: dynamics and regulation},
 journal = {Research and Reports in Biology}
}

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 title = {Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle},
 journal = {Science}
}

@article{Liu2012,
 year = {2012},
 publisher = {Frontiers Media {SA}},
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 author = {Zhihong Liu and Hans J. Vogel},
 title = {Structural basis for the regulation of {L-type} voltage-gated calcium channels: interactions between the N-terminal cytoplasmic domain and Ca\textsuperscript{2+}-calmodulin},
 journal = {Frontiers in Molecular Neuroscience}
}


@article{Fallon2009,
 year = {2009},
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 publisher = {Proceedings of the National Academy of Sciences},
 volume = {106},
 number = {13},
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 author = {J. L. Fallon and M. R. Baker and L. Xiong and R. E. Loy and G. Yang and R. T. Dirksen and S. L. Hamilton and F. A. Quiocho},
 title = {Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca\textsuperscript{2+}-calmodulins},
 journal = {Proceedings of the National Academy of Sciences}
}



@article{Hite2017,
 year = {2017},
 month = {jan},
 publisher = {Elsevier {BV}},
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 number = {3},
 pages = {390-399},
 author = {Richard K. Hite and Roderick MacKinnon},
 title = {Structural Titration of {Slo2.2}, a {Na\textsuperscript{+}-dependent {K\textsuperscript{+}} channel}},
 journal = {Cell}
}


@article{Zamponi2015,
 year = {2015},
 month = {sep},
 publisher = {American Society for Pharmacology {\&} Experimental Therapeutics ({ASPET})},
 volume = {67},
 number = {4},
 pages = {821-870},
 author = {G. W. Zamponi and J. Striessnig and A. Koschak and A. C. Dolphin},
 title = {The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential},
 journal = {Pharmacological Reviews}
}

@article{Hondeghem1984,
 year = {1984},
 month = {apr},
 publisher = {Annual Reviews},
 volume = {24},
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 pages = {387-423},
 author = {L M Hondeghem and B G Katzung},
 title = {Antiarrhythmic Agents: the Modulated Receptor Mechanism of Action of Sodium and Calcium Channel Blocking Drugs},
 journal = {Annual Review of Pharmacology and Toxicology}
}


@article{Tang2016,
 year = {2016},
 month = {aug},
 publisher = {Springer Nature},
 volume = {537},
 number = {7618},
 pages = {117-121},
 author = {Lin Tang and Tamer M. Gamal El-Din and Teresa M. Swanson and David C. Pryde and Todd Scheuer and Ning Zheng and William A. Catterall},
 title = {Structural basis for inhibition of a voltage-gated {Ca}\textsuperscript{2+} channel by {Ca}\textsuperscript{2+} antagonist drugs},
 journal = {Nature}
}


@article{Catacuzzeno1999,
 year = {1999},
 month = {apr},
 publisher = {Wiley-Blackwell},
 volume = {126},
 number = {8},
 pages = {1699-1706},
 author = {L Catacuzzeno and C Trequattrini and A Petris and F Franciolini},
 title = {Mechanism of verapamil block of a neuronal delayed rectifier {K}\textsuperscript{+} channel: active form of the blocker and location of its binding domain},
 journal = {British Journal of Pharmacology}
}
@article{Harper2001,
 year = {2001},
 month = {jan},
 publisher = {Springer Nature},
 volume = {179},
 number = {2},
 pages = {103-111},
 author = {A.A. Harper and L. Catacuzzeno and C. Trequattrini and A. Petris and F. Franciolini},
 title = {Verapamil Block of Large-Conductance {Ca}\textsuperscript{2+}-Activated {K}\textsuperscript{+} Channels in Rat Aortic Myocytes},
 journal = {Journal of Membrane Biology}
}%10.1007%2Fs002320010041.pdf




@article{Affolter1986,
 year = {1986},
 month = {mar},
 publisher = {Elsevier {BV}},
 volume = {49},
 number = {3},
 pages = {767-771},
 author = {H. Affolter and R. Coronado},
 title = {Sidedness of reconstituted calcium channels from muscle transverse tubules as determined by {D600} and {D890} blockade},
 journal = {Biophysical Journal}
}
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 year = {1993},
 month = {oct},
 publisher = {American Society for Clinical Investigation},
 volume = {92},
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 pages = {1795-1804},
 author = {D C Rockey and C N Housset and S L Friedman},
 title = {Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo.},
 journal = {Journal of Clinical Investigation}
}%jcinvest00042-0207.pdf


@article{McWilliam2013,
 year = {2013},
 month = {may},
 publisher = {Oxford University Press ({OUP})},
 volume = {41},
 number = {W1},
 pages = {W597-W600},
 author = {Hamish McWilliam and Weizhong Li and Mahmut Uludag and Silvano Squizzato and Young Mi Park and Nicola Buso and Andrew Peter Cowley and Rodrigo Lopez},
 title = {Analysis Tool Web Services from the {EMBL}-{EBI}},
 journal = {Nucleic Acids Research}
}


@article{Li2015,
 year = {2015},
 month = {apr},
 publisher = {Oxford University Press ({OUP})},
 volume = {43},
 number = {W1},
 pages = {W580-W584},
 author = {Weizhong Li and Andrew Cowley and Mahmut Uludag and Tamer Gur and Hamish McWilliam and Silvano Squizzato and Young Mi Park and Nicola Buso and Rodrigo Lopez},
 title = {The {EMBL}-{EBI} bioinformatics web and programmatic tools framework},
 journal = {Nucleic Acids Research}
}

@article{Zhou2015,
 year = {2015},
 month = {oct},
 publisher = {American Society for Biochemistry {\&} Molecular Biology ({ASBMB})},
 volume = {290},
 number = {51},
 pages = {30616-30623},
 author = {Meng-Hua Zhou and Alexis Bavencoffe and Hui-Lin Pan},
 title = {Molecular Basis of Regulating High Voltage-Activated Calcium Channels {byS}-Nitrosylation},
 journal = {Journal of Biological Chemistry}
}
@article{Bataller2001,
 year = {2001},
 month = {apr},
 publisher = {Wiley-Blackwell},
 volume = {33},
 number = {4},
 pages = {956-962},
 author = {R Bataller},
 title = {In vitro and in vivo activation of rat hepatic stellate cells results in de novo expression of L-type voltage-operated calcium channels},
 journal = {Hepatology}
}


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 year = {1999},
 month = {feb},
 publisher = {Proceedings of the National Academy of Sciences},
 volume = {96},
 number = {4},
 pages = {1357-1362},
 author = {H. Yamaguchi and J. N. Muth and M. Varadi and A. Schwartz and G. Varadi},
 title = {Critical role of conserved proline residues in the transmembrane segment 4 voltage sensor function and in the gating of {L-type} calcium channels},
 journal = {Proceedings of the National Academy of Sciences}
}


@article{Wegener1996,
 year = {1996},
 month = {dec},
 publisher = {Springer Nature},
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 number = {6},
 pages = {746-754},
 author = {J\"org W. Wegener and Hermann Nawrath},
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 journal = {Naunyn-Schmiedeberg{\textquotesingle}s Archives of Pharmacology}
}%10.1007%2FBF00166901.pdf


@article{Catterall2000,
 year = {2000},
 month = {nov},
 publisher = {Annual Reviews},
 volume = {16},
 number = {1},
 pages = {521-555},
 author = {William A. Catterall},
 title = {Structure and Regulation of Voltage-Gated {Ca\textsuperscript{2+}} Channels},
 journal = {Annual Review of Cell and Developmental Biology}
}
@article{Catterall2008,
 year = {2008},
 month = {sep},
 publisher = {Elsevier {BV}},
 volume = {59},
 number = {6},
 pages = {882-901},
 author = {William A. Catterall and Alexandra P. Few},
 title = {Calcium Channel Regulation and Presynaptic Plasticity},
 journal = {Neuron}
}
@article{Hering2000,


 year = {2000},

 month = {oct},

 publisher = {Wiley-Blackwell},

 volume = {528},

 number = {2},

 pages = {237-249},

 author = {Steffen Hering and Stanislav Berjukow and Stanislav Sokolov and Rainer Marksteiner and Regina G. Wei{\ss} and Richard Kraus and Evgeni N. Timin},

 title = {Molecular determinants of inactivation in voltage-gated {Ca\textsuperscript{2+}} channels},

 journal = {The Journal of Physiology}

}



@article{Hering1996,


 year = {1996},

 month = {oct},

 publisher = {American Society for Biochemistry {\&} Molecular Biology ({ASBMB})},

 volume = {271},

 number = {40},

 pages = {24471-24475},

 author = {Steffen Hering and Stefan Acz{\'{e}}l and Manfred Grabner and Frank D\"{o}ring and Stanislav Berjukow and J\"{o}rg Mitterdorfer and Martina J. Sinnegger and J\"{o}rg Striessnig and Vadim E. Degtiar and Zhengyi Wang and Hartmut Glossmann},

 title = {Transfer of High Sensitivity for Benzothiazepines from {L-type} to Class {A} ({BI}) Calcium Channels},

 journal = {Journal of Biological Chemistry}

}





@article{Lipkind2011,


 year = {2011},

 month = {nov},

 publisher = {Informa {UK} Limited},

 volume = {5},

 number = {6},

 pages = {482-488},

 author = {Gregory M. Lipkind and Harry A. Fozzard and Dorothy A. Hanck},

 title = {A molecular model of the inner pore of the {Ca\textsuperscript{2+}} channel in its open state},

 journal = {Channels}

}







@article{Lipkind2003,


 year = {2003},

 month = {mar},

 publisher = {American Society for Pharmacology {\&} Experimental Therapeutics ({ASPET})},

 volume = {63},

 number = {3},

 pages = {499-511},

 author = {Gregory M. Lipkind and Harry A. Fozzard},

 title = {Molecular Modeling of Interactions of Dihydropyridines and Phenylalkylamines with the Inner Pore of the {L-type} {Ca\textsuperscript{2+}} Channel},

 journal = {Molecular Pharmacology}

}





@article{Carpy1985,


 year = {1985},

 month = {apr},

 publisher = {International Union of Crystallography ({IUCr})},

 volume = {41},

 number = {4},

 pages = {624-627},

 author = {A. Carpy and J. M. L{\'{e}}ger and C. Melchiorre},

 title = {Structure of $\upalpha$-isopropyl-$\upalpha$-[(N-methyl-N-homoveratryl)-$\upgamma$-aminopropyl]-3, 4-dimethoxyphenylacetonitrile hydrochloride, verapamil, {C\textsubscript{27}H\textsubscript{38}N\textsubscript{2}O\textsubscript{4}}.{HCl}},

 journal = {Acta Crystallographica Section C Crystal Structure Communications}

}





@article{Arnold2005,


 year = {2005},

 month = {nov},

 publisher = {Oxford University Press ({OUP})},

 volume = {22},

 number = {2},

 pages = {195-201},

 author = {Konstantin Arnold and Lorenza Bordoli and J\"{u}rgen Kopp and Torsten Schwede},

 title = {The {SWISS}-{MODEL} workspace: a web-based environment for protein structure homology modelling},

 journal = {Bioinformatics}

}





@article{Bordoli2008,


 year = {2008},

 month = {dec},

 publisher = {Springer Nature},

 volume = {4},

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volume = {80}, 

number = {3}, 

pages = {860-864}, 

year = {1983}, 

abstract ={[3H]Nitrendipine binding to drug receptor sites associated with calcium channels is allosterically regulated by a diverse group of calcium channel antagonists. Verapamil, D-600 (methoxyverapamil), tiapamil, lidoflazine, flunarizine, cinnarizine, and prenylamine all reduce [3H]nitrendipine binding affinity. By contrast, diltiazem, a benzothiazepine calcium channel antagonist, enhances [3H]nitrendipine binding. All these drug effects involve a single site allosterically linked to the [3H]nitrendipine binding site. Inhibition of [3H]nitrendipine binding by prenylamine, lidoflazine, or tiapamil is reversed by D-600 and diltiazem, which alone respectively slightly reduce or enhance [3H]nitrendipine binding. Diltiazem reverses the inhibition of [3H]nitrendipine binding by D-600. Our prediction that drugs allosterically regulating [3H]nitrendipine binding should be calcium antagonists is confirmed by calcium antagonism in guinea pig ileum observed with the antihistamine dimethindene, the neuroleptics thioridazine and mesoridazine, and the anticholinergic biperiden.}, 


journal = {Proceedings of the National Academy of Sciences} 

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 publisher = {Springer Nature},
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 author = {R. Mannhold and R. Steiner and W. Haas and R. Kaufmann},
 title = {Investigations on the structure-activity relationships of verapamil},
 journal = {Naunyn-Schmiedeberg{\textquotesingle}s Archives of Pharmacology}
}


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	title = {Calcium measurements in organelles with {Ca\textsuperscript{2+}}-sensitive fluorescent proteins},

	journal = {Cell Calcium}

}









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	title = {What do we not know about mitochondrial potassium channels?},

	journal = {Biochimica et Biophysica Acta ({BBA}) - Bioenergetics}

}









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	number = {7},

	pages = {1541-1549},

	author = {Annette C. Dolphin},

	title = {The $\upalpha$2$\updelta$ subunits of voltage-gated calcium channels},

	journal = {Biochimica et Biophysica Acta ({BBA}) - Biomembranes}

}









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	title = {The ~2~ subunits of voltage-gated calcium channels form {GPI}-anchored proteins, a posttranslational modification essential for function},

	journal = {Proceedings of the National Academy of Sciences}

}









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	volume = {77},

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	title = {{CACNA}1D De Novo Mutations in Autism Spectrum Disorders Activate {Ca\textsubscript{V}1.3} {L-type} Calcium Channels},

	journal = {Biological Psychiatry}

}













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	volume = {88},

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	author = {Daniel L Burgess and Julie M Jones and Miriam H Meisler and Jeffrey L Noebels},

	title = {Mutation of the {Ca\textsuperscript{2+}} Channel $\upbeta$ Subunit Gene Cchb4 Is Associated with Ataxia and Seizures in the Lethargic (lh) Mouse},

	journal = {Cell}

}









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	title = {{CaV}1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism},

	journal = {Cell}

}









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}









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author = {Hering, Steffen and Aczél, Stefan and Kraus, Richard L. and Berjukow, Stanislav and Striessnig, J\"org and Timin, Eugen N.}, 

title = {Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: Role of inactivation},

volume = {94}, 

number = {24}, 

pages = {13323-13328}, 

year = {1997}, 
journal = {Proceedings of the National Academy of Sciences} 
}









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	author = {Steffen Hering and Stanislav Berjukow and Stefan Acz{\'{e}}l and Eugen N. Timin},

	title = {{Ca\textsuperscript{2+}} channel block and inactivation: common molecular determinants},

	journal = {Trends in Pharmacological Sciences}

}









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	title = {Effect of verapamil on mortality and major events after acute myocardial infarction (The Danish Verapamil Infarction Trial {II} {\textemdash} {DAVIT} {II})},

	journal = {The American Journal of Cardiology}

}











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	author = {Takeshi Kobayashi and Yoichi Yamada and Mitsuhiro Fukao and Masaaki Tsutsuura and Noritsugu Tohse},

	title = {Regulation of {CaV}1.2 Current: Interaction With Intracellular Molecules},

	journal = {Journal of Pharmacological Sciences}

}









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	title = {Effects of N-n-butyl Haloperidol Iodide on Myocardial Ischemia/Reperfusion Injury and Egr-1 Expression in Rat},

	journal = {Acta Biochimica et Biophysica Sinica}

}









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	title = {Interactions of Calmodulin With the Multiple Binding Sites of Ca\textsubscript{V}1.2 {Ca\textsuperscript{2+}} Channels},

	journal = {Journal of Pharmacological Sciences}

}









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	title = {Effect of Vacuolar Proton {ATPase} on {pHi}, {Ca\textsuperscript{2+}}, and Apoptosis in Neonatal Cardiomyocytes During Metabolic Inhibition/Recovery},

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}











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 year = {2000},
 month = {dec},
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 author = {Gregory H. Hockerman and Nejmi Dilmac and Todd Scheuer and William A. Catterall},
 title = {Molecular Determinants of Diltiazem Block in Domains {IIIS}6 and {IVS}6 of {L-type} {Ca\textsuperscript{2+}} Channels},
 journal = {Molecular Pharmacology}
}







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	title = {Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition},

	journal = {Hepatology}

}









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	author = {Filip Van Petegem and Franck C Chatelain and Daniel L Minor,},

	title = {Insights into voltage-gated calcium channel regulation from the structure of the {CaV}1.2 {IQ} domain{\textendash}{Ca\textsuperscript{2+}}/calmodulin complex},

	journal = {Nature Structural {\&} Molecular Biology}

}









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	title = {The {EEEE} Locus Is the Sole High-Affinity {Ca\textsuperscript{2+}} Binding Structure in the Pore of a Voltage-Gated {Ca\textsuperscript{2+}} Channel},

	journal = {The Journal of General Physiology}

}









@article{4038d6dd1c804448a5864feb4e243dc3,

title = "Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel",

abstract = "IN cardiac muscle, where Ca2+ influx across the sarcolemma is essential for contraction, the dihydropyridine (DHP)-sensitive {L-type} calcium channel represents the major entry pathway of extracellular Ca2+. We have previously elucidated the primary structure of the rabbit skeletal muscle DHP receptor by cloning and sequencing the complementary DNA. An expression plasmid carrying this cDNA, microinjected into cultured skeletal muscle cells from mice with muscular dysgenesis, has been shown to restore both excitation-contraction coupling and slow calcium current missing from these cells, so that a dual role for the DHP receptor in skeletal muscle transverse tubules is suggested. We report here the complete amino-acid sequence of the rabbit cardiac DHP receptor, deduced from the cDNA sequence. We also show that messenger RNA derived from the cardiac DHP receptor cDNA is sufficient to direct the formation of a functional DHP-sensitive calcium channel in Xenopus oocytes. Furthermore, higher calcium-channel activity is observed when mRNA specific for the polypeptide of relative molecular mass 140,000 (alfa2-subunit) associated with the skeletal muscle DHP receptor is co-injected.",

author = "Atsushi Mikami and Keiji Imoto and Tsutomu Tanabe and Tetsuhiro Niidome and Yasuo Mori and Hiroshi Takeshima and Shuh Narumiya and Shosaku Numa",

year = "1989",

volume = "340",

pages = "230-233",

journal = "Nature",

publisher = "Nature Publishing Group",

number = "6230"

}









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	title = {Cardiac excitation{\textendash}contraction coupling},

	journal = {Nature}

}


@article{Tang2004,
 year = {2004},
 month = {aug},
 publisher = {American Society for Biochemistry {\&} Molecular Biology ({ASBMB})},
 volume = {279},
 number = {43},
 pages = {44335-44343},
 author = {Zhen Zhi Tang and Mui Cheng Liang and Songqing Lu and Dejie Yu and Chye Yun Yu and David T. Yue and Tuck Wah Soong},
 title = {Transcript Scanning Reveals Novel and Extensive Splice Variations in Human {L-type} Voltage-gated Calcium Channel, {Ca\textsubscript{V}1.2} \textalpha\textsubscript{1} Subunit},
 journal = {Journal of Biological Chemistry}
}






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}









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	title = {Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle},

	journal = {Science}

} 









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	title = {Regulation of Cardiac {L-type} {Ca\textsuperscript{2+}} Channel {Ca\textsubscript{V}1.2} Via the \textbeta-Adrenergic-{cAMP}-Protein Kinase A Pathway: Old Dogmas, Advances, and New Uncertainties},

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} 









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}









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	volume = {64},

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	title = {Molecular Determinants of {Ca\textsuperscript{2+}} Potentiation of Diltiazem Block and {Ca\textsuperscript{2+}}-Dependent Inactivation in the Pore Region of {Ca\textsubscript{V}1.2}},

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}









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}









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	title = {Cellular mechanisms of ischemia-reperfusion injury},

	journal = {The Annals of Thoracic Surgery}

}









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	author = {Anamika Singh and Daniel Hamedinger and Jean-Charles Hoda and Mathias Gebhart and Alexandra Koschak and Christoph Romanin and J\"org Striessnig},

	title = {C-terminal modulator controls {Ca\textsuperscript{2+}}-dependent gating of {Ca\textsubscript{V}1.4} {L-type} {Ca\textsuperscript{2+}} channel},

	journal = {Nature Neuroscience}

}









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	title = {Alternative Splicing of the {CaV}1.3 Channel {IQ} Domain, a Molecular Switch for {Ca\textsuperscript{2+}}-Dependent Inactivation within Auditory Hair Cells},

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}









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}









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	author = {Megumi Fukuyama and Seiko Ohno and Qi Wang and Hiromi Kimura and Takeru Makiyama and Hideki Itoh and Makoto Ito and Minoru Horie},

	title = {{L-type} Calcium Channel Mutations in {Japanese} Patients With Inherited Arrhythmias},

	journal = {Circulation Journal}

}









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	title = {{Ca\textsuperscript{2+}}/Calmodulin Regulates Trafficking of {CaV}1.2 {Ca\textsuperscript{2+}} Channels in Cultured Hippocampal Neurons},

	journal = {Journal of Neuroscience}

}













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	title = {Auxiliary subunits: essential components of the voltage-gated calcium channel complex},

	journal = {Current Opinion in Neurobiology}

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	pages = {430-442},

	author = {I. S. Harper and J. M. Bond and E. Chacon and J. M. Reece and B. Herman and J. J. Lemasters},

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	title = {Temperature-dependence of {L-type} {Ca\textsuperscript{2+}} current in ventricular cardiomyocytes of the {Alaska} blackfish (\textit{Dallia pectoralis})},

	journal = {Journal of Comparative Physiology B}

}









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	author = {Ping Liao and Tuck Wah Soong},

	title = {{CaV}1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency},

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}









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	volume = {460},

	number = {2},

	pages = {361-374},

	author = {J\"org Striessnig and Hanno J\"orn Bolz and Alexandra Koschak},

	title = {Channelopathies in {Ca\textsubscript{V}1.1}, {Ca\textsubscript{V}1.3} and {Ca\textsubscript{V}1.4} voltage-gated {L-type} {Ca\textsuperscript{2+}} channels},

	journal = {Pfl\"ugers Archiv - European Journal of Physiology}

}









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	volume = {357},

	number = {2},

	pages = {463-476},

	author = {Stefan M. Berger and Dusan Bartsch},

	title = {The role of {L-type} voltage-gated calcium channels {Ca\textsubscript{V}1.2} and {Ca\textsubscript{V}1.3} in normal and pathological brain function},

	journal = {Cell and Tissue Research}

}









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	year = 2009,

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	volume = {1788},

	number = {12},

	pages = {2471-2480},

	author = {Attila Malasics and Dirk Gillespie and Wolfgang Nonner and Douglas Henderson and Bob Eisenberg and Dezs{\H{o}} Boda},

	title = {Protein structure and ionic selectivity in calcium channels: selectivity filter size, not shape, matters},

	journal = {Biochimica et Biophysica Acta ({BBA}) - Biomembranes}

}









@article{Boda_2009,


	year = 2009,

	month = {apr},

	publisher = {Rockefeller University Press},

	volume = {133},

	number = {5},

	pages = {497-509},

	author = {Dezs{\H{o}} Boda and M{\'{o}}nika Valisk{\'{o}} and Douglas Henderson and Bob Eisenberg and Dirk Gillespie and Wolfgang Nonner},

	title = {Ionic selectivity in {L-type} calcium channels by electrostatics and hard-core repulsion},

	journal = {The Journal of General Physiology}

}









@article{Kim_1993,


	year = 1993,

	month = {mar},

	publisher = {Wiley-Blackwell},

	volume = {318},

	number = {2},

	pages = {145-148},

	author = {Man-Suk Kim and Takashi Morii and Li-Xin Sun and Keiji Imoto and Yasuo Mori},

	title = {Structural determinants of ion selectivity in brain calcium channel},

	journal = {{FEBS} Letters}

}









@article{Fahlke_1997,


	year = 1997,

	month = {nov},

	publisher = {Rockefeller University Press},

	volume = {110},

	number = {5},

	pages = {551-564},

	author = {Christoph Fahlke and Christine D\"urr and Alfred L. George},

	title = {Mechanism of Ion Permeation in Skeletal Muscle Chloride Channels},

	journal = {The Journal of General Physiology}

}









@article{Shomer_1994,


	year = 1994,

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	publisher = {Elsevier {BV}},

	volume = {67},

	number = {2},

	pages = {641-646},

	author = {N.H. Shomer and J.R. Mickelson and C.F. Louis},

	title = {Ion selectivity of porcine skeletal muscle {Ca\textsuperscript{2+}} release channels is unaffected by the Arg615 to Cys615 mutation},

	journal = {Biophysical Journal}

}









@article{Tang_1993,


	year = 1993,

	month = {dec},

	publisher = {Elsevier {BV}},

	volume = {11},

	number = {6},

	pages = {1013-1021},

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	author = {El{\.{z}}bieta Kania and Beata Paj{\k{a}}k and Jim O{\textquotesingle}Prey and Pablo Sierra Gonzalez and Anna Litwiniuk and Kaja Urba{\'{n}}ska and Kevin M. Ryan and Arkadiusz Orzechowski},

	title = {Verapamil treatment induces cytoprotective autophagy by modulating cellular metabolism},

	journal = {The {FEBS} Journal}

}









@article{Zhang_2017,


	year = 2017,

	month = {may},

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	volume = {9},

	number = {23},

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	author = {Huiyuan Zhang and Wei Jiang and Ruiling Liu and Jing Zhang and Di Zhang and Zhonghao Li and Yuxia Luan},

	title = {Rational Design of Metal Organic Framework Nanocarrier-Based Codelivery System of Doxorubicin Hydrochloride/Verapamil Hydrochloride for Overcoming Multidrug Resistance with Efficient Targeted Cancer Therapy},

	journal = {{ACS} Applied Materials {\&} Interfaces}

}









@article{El_Nahas_2016,


	year = 2016,

	month = {oct},

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	volume = {119},

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	author = {Ahmed R. El-Nahas and Mohamed M. Elsaadany and Diaa-Eldin Taha and Ahmed M. Elshal and Mohamed Abo El-Ghar and Amani M. Ismail and Essam A. Elsawy and Hazem H. Saleh and Ehab W. Wafa and Amira Awadalla and Tamer S. Barakat and Khaled Z. Sheir},

	title = {A randomised controlled trial evaluating renal protective effects of selenium with vitamins A, C, E, verapamil, and losartan against extracorporeal shockwave lithotripsy-induced renal injury},

	journal = {{BJU} International}

}









@article{Echeverri_2017,


	year = 2017,

	month = {nov},

	publisher = {Ovid Technologies (Wolters Kluwer Health)},

	pages = {1},

	author = {Juan Echeverri and Nicolas Goldaracena and Johan Moritz Kaths and Ivan Linares and Roizar Roizales and Dagmar Kollmann and Matyas Hamar and Peter Urbanellis and Sujani Ganesh and Oyedele A. Adeyi and Mahmood Tazari and Markus Selzner and Nazia Selzner},

	title = {Comparison of {BQ}123, Epoprostenol, and Verapamil as Vasodilators During Normothermic Ex Vivo Liver Machine Perfusion},

	journal = {Transplantation}

}









@article{Raaphorst_2017,


	year = 2017,

	month = {jul},

	publisher = {American Chemical Society ({ACS})},

	volume = {8},

	number = {9},

	pages = {1925-1936},

	author = {Renske M. Raaphorst and Gert Luurtsema and Robert C. Schuit and Esther J. M. Kooijman and Philip H. Elsinga and Adriaan A. Lammertsma and Albert D. Windhorst},

	title = {Synthesis and Evaluation of New Fluorine-18 Labeled Verapamil Analogs To Investigate the Function of P-Glycoprotein in the Blood{\textendash}Brain Barrier},

	journal = {{ACS} Chemical Neuroscience}

}Publication Date (Web): June 26, 2017









@article{Miyake_2017,


	year = 2017,

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	publisher = {Elsevier {BV}},

	volume = {140},

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	author = {Marcel M. Miyake and Angela Nocera and Patricia Levesque and Rong Guo and Christine A. Finn and Jeremy Goldfarb and Stacey Gray and Eric Holbrook and Nicolas Busaba and Jose Eduardo L. Dolci and Benjamin S. Bleier},

	title = {Double-blind placebo-controlled randomized clinical trial of verapamil for chronic rhinosinusitis with nasal polyps},

	journal = {Journal of Allergy and Clinical Immunology}

}









@article{de_Knegt_2017,


	year = 2017,

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	volume = {49},

	number = {3},

	pages = {302-307},

	author = {Gerjo J. de Knegt and Aart van der Meijden and Corn{\'{e}} P. de Vogel and Rob E. Aarnoutse and Jurriaan E.M. de Steenwinkel},

	title = {Activity of moxifloxacin and linezolid against Mycobacterium tuberculosis in combination with potentiator drugs verapamil, timcodar, colistin and {SQ}109},

	journal = {International Journal of Antimicrobial Agents}

}Highlights









@article{Watanabe_2017,


	year = 2017,

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	volume = {58},

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	author = {Ichiro Watanabe and Leonard S. Gettes},

	title = {Effects of Propranolol and Verapamil on Changes in {TQ} and {ST} Segment Potentials During Graded Coronary Flow Reduction in a Porcine Myocardial Ischemia Model},

	journal = {International Heart Journal}

}International Heart Journal









@article{Yin_2017,


	year = 2017,

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	volume = {102},

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	author = {Ti Yin and Shu-Chen Kuo and Yea-Yuan Chang and Yung-Tai Chen and Kai-Wei Katherine Wang},

	title = {Verapamil Use Is Associated With Reduction of Newly Diagnosed Diabetes Mellitus},

	journal = {The Journal of Clinical Endocrinology {\&} Metabolism}

}Abstract









@article{Britton_2017,


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	volume = {8},

	author = {Oliver J. Britton and Najah Abi-Gerges and Guy Page and Andre Ghetti and Paul E. Miller and Blanca Rodriguez},

	title = {Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual Action Potential Variability},

	journal = {Frontiers in Physiology}

}









@article{Ajima_2016,


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	author = {Malachy N. O. Ajima and Pramod K. Pandey and Kundan Kumar and Nalini Poojary},

	title = {Assessment of mutagenic, hematological and oxidative stress biomarkers in liver of Nile tilapia, Oreochromis niloticus (Linnaeus, 1758) in response to sublethal verapamil exposure},

	journal = {Drug and Chemical Toxicology}

} 









@article{2013,


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}









@article{Guo_2017,


	year = 2017,

	month = {mar},

	publisher = {Elsevier {BV}},

	volume = {151},

	pages = {119-127},

	author = {Yuanyuan Guo and Wenxiu He and Shengfeng Yang and Dujuan Zhao and Zhonghao Li and Yuxia Luan},

	title = {Co-delivery of docetaxel and verapamil by reduction-sensitive {PEG}-{PLGA}-{SS}-{DTX} conjugate micelles to reverse the multi-drug resistance of breast cancer},

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}









@article{Lee_2017,


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	volume = {50},

	number = {2},

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	author = {Da Hyun Lee and Jeong Su Park and Yu Seol Lee and Su Haeng Sung and Yong-ho Lee and Soo Han Bae},

	title = {The hypertension drug, verapamil, activates Nrf2 by promoting p62-dependent autophagic Keap1 degradation and prevents acetaminophen-induced cytotoxicity},

	journal = {{BMB} Reports }

}









@article{Fraser_2017,


	year = 2017,

	month = {apr},

	publisher = {{SAGE} Publications},

	volume = {37},

	number = {11},

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	author = {Justin F Fraser and Michael Maniskas and Amanda Trout and Doug Lukins and Lindsey Parker and W Lane Stafford and Abdulnasser Alhajeri and Jill Roberts and Gregory J Bix},

	title = {Intra-arterial verapamil post-thrombectomy is feasible, safe, and neuroprotective in stroke},

	journal = {Journal of Cerebral Blood Flow {\&} Metabolism}

}









@article{Abdelaziz_2017,


	year = 2017,

	month = {jan},

	publisher = {Ovid Technologies (Wolters Kluwer Health)},

	volume = {28},

	number = {1},

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	author = {Hesham K. Abdelaziz and Wael Elkilany and Said Khalid and Sameh Sabet and Marwan Saad},

	title = {Efficacy and safety of intracoronary verapamil versus sodium nitroprusside for the prevention of microvascular obstruction during primary percutaneous coronary intervention for {ST}-segment elevation myocardial infarction},

	journal = {Coronary Artery Disease}

}Efficacy and safety of intracoronary verapamil versus sodium nitroprusside for the prevention of microvascular obstruction during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction









@article{Nikouee_2012,


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	volume = {167},

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	author = {Azadeh Nikouee and Malika Janbein and Stephan Grissmer},

	title = {Verapamil- and state-dependent effect of 2-aminoethylmethanethiosulphonate ({MTSEA}) {onhKv}1.3 channels},

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}bph0167-1378.pdf









@article{Ham_2017,


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	volume = {39},

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	author = {Seok Won Ham and Hee-Young Jeon and Hyunggee Kim},

	title = {Verapamil augments carmustine- and irradiation-induced senescence in glioma cells by reducing intracellular reactive oxygen species and calcium ion levels},

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}1010428317692244.pdf









@article{Navamanisubramanian_2017,


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	author = {Raja Navamanisubramanian and Raghunandan Nerella and Chamundeeswari D and Shanmuganathan Seetharaman},

	title = {Use of Okra Mucilage and Chitosan Acetate in Verapamil Hydrochloride buccal patches development$\mathsemicolon$ In vitro and Ex vivo Characterization},

	journal = {Journal of Young Pharmacists}

}









@article{Perumalla_2012,


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	author = {Sathyanarayana Reddy Perumalla and Changquan Calvin Sun},

	title = {Confused {HCl}: Hydrogen Chloride or Hydrochloric Acid?},

	journal = {Chemistry - A European Journal}

}









@article{Vijayabaskar_2017,


	year = 2017,

	month = {apr},

	publisher = {Elsevier {BV}},

	volume = {137},

	pages = {189-195},

	author = {S. Vijayabaskar and V. Mahalingam and Kalaivani},

	title = {Analytical method development and validation for the analysis of verapamil hydrochloride and its related substances by using ultra perfomance liquid chromatography},

	journal = {Journal of Pharmaceutical and Biomedical Analysis}

}Highlights









@article{Muhammad_2017,


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	volume = {7},

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	author = {Sohail Muhammad and Guanhong Xu and Fangdi Wei and Yujie Ma and Yunsu Ma and Yueyue Song and Menglan Shi and Xiaoman Xu and Yao Cen and Qin Hu},

	title = {Determination of Verapamil {HCl} in Pharmaceutical Preparations by a Fluorescent Nano Probe Based on {CdTe}/{CdS}/{ZnS} Quantum Dots},

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}








@article{Ok_2017,


	year = 2017,

	month = {jul},

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	pages = {096032711772196},

	author = {S-H Ok and I-W Shin and SH Lee and J Park and MS Woo and J-M Hong and J Kim and J-T Sohn},

	title = {Lipid emulsion alleviates the vasodilation and mean blood pressure decrease induced by a toxic dose of verapamil in isolated rat aortae and an in vivo rat model},

	journal = {Human {\&} Experimental Toxicology}

}S-H Ok1, 2, I-W Shin1, 2, SH Lee1, J Park3, MS Woo1, J-M Hong4, J Kim1, J-T Sohn1, 2









@article{Popovi__2017,


	year = 2017,

	month = {jan},

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	volume = {7},

	author = {Natalija Popovi{\'{c}} and Ver{\'{o}}nica Gim{\'{e}}nez de B{\'{e}}jar and Mar{\'{\i}}a Caballero-Bleda and Miroljub Popovi{\'{c}}},

	title = {Verapamil Parameter- and Dose-Dependently Impairs Memory Consolidation in Open Field Habituation Task in Rats},

	journal = {Frontiers in Pharmacology}

}Verapamil Parameter- and Dose-Dependently Impairs Memory Consolidation in Open Field Habituation Task in Rats









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	title = {Polymer nanocapsules for the intracellular delivery of hydrophobic and hydrophilic anticancer drugs},

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}









@article{Jouyban_2017,


	year = 2017,

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	volume = {40},

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	pages = {3318-3326},

	author = {Abolghasem Jouyban and Samin Hamidi},

	title = {Dispersive micro-solid-phase extraction using carbon-based adsorbents for the sensitive determination of verapamil in plasma samples coupled with capillary electrophoresis},

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}Jouyban_et_al-2017-Journal_of_Separation_Science.pdf









@article{Patel_2017,


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	volume = {2},

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	author = {Nita J Patel and Nathan Yumibe and Kenneth Ruterbories and Naijia Huang and Lee Burns and Jeffrey Tan and David White and Jason Liu and Derek Brocksmith and Guy Bouchard and Alain Stricker-Krongrad},

	title = {Pharmacokinetics of intravenous and oral metformin and r,s-verapamil in Sinclair, Hanford, Yucatan and G\"ottingen minipigs},

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}









@article{Routray_2017,


	year = 2017,

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	volume = {11},

	number = {3},

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	author = {SidharthSraban Routray and Debasis Mishra and Daityari Routray and Kasturi Nanda},

	title = {Effect of verapamil as an adjuvant to levobupivacaine in supraclavicular brachial plexus block},

	journal = {Anesthesia: Essays and Researches}

}









@article{Webster_2017,


	year = 2017,

	month = {aug},

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	pages = {bcr-2017-220568},

	author = {Gregory Webster and Zachary J Schoppen and Alfred L George},

	title = {Treatment of calmodulinopathy with verapamil},

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}









@article{Huang_2017,


	year = 2017,

	month = {aug},

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	pages = {1-6},

	author = {Yixiang Huang and Junyong Zhao and Wei Jian and Gang Wang},

	title = {Effects of verapamil on the pharmacokinetics of dihydromyricetin in rats and its potential mechanism},

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}1.	This study investigates the effects of verapamil on the pharmacokinetics of dihydromyricetin in rats and clarifies its main mechanism.









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	author = {Tong Zhu and Corrie Howieson and Tomasz Wojtkowski and Jay P. Garg and David Han and Ogert Fisniku and James Keirns},

	title = {The Effect of Verapamil, a P-Glycoprotein Inhibitor, on the Pharmacokinetics of Peficitinib, an Orally Administered, Once-Daily {JAK} Inhibitor},

	journal = {Clinical Pharmacology in Drug Development}

}








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	title = {The effects of verapamil and its combinations with glutamate and glycine on cardiodynamics, coronary flow and oxidative stress in isolated rat heart},

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}









@article{Kant_2017,


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	title = {A new treatment of hypertrophic and keloid scars with combined triamcinolone and verapamil: a retrospective study},

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}









@article{Afrooz_2017,


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	month = {oct},

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	author = {Hamideh Afrooz and Fatemeh Ahmadi and Farzaneh Fallahzadeh and Seyed Hossein Mousavi-Fard and Shohreh Alipour},

	title = {Design and characterization of paclitaxel-verapamil co-encapsulated {PLGA} nanoparticles: Potential system for overcoming P-glycoprotein mediated {MDR}},

	journal = {Journal of Drug Delivery Science and Technology}

}Pharmaceutical Sciences Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran









@article{Shokri_2017,


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	volume = {71},

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	author = {Mitra Shokri and Reza Moradpour and Majid Shafaroudi and Nourollah Rezaei and Shervin Tabar},

	title = {Comparing the Effects of Krebs Plus Verapamil Solution on Endothelial Function of Harvested Human Greater Saphenous Vein with Heparinized Blood, an Invitro Study

		},

	journal = {Medical Archives}

}MA-71-188.pdf









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}









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	author = {Leandro Bueno Bergantin and Afonso Caricati Neto},

	title = {A 4-Decade Enigma, Two Researchers and a Wonderful History},

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}









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	title = {A Case Report-Primary Vaginismus: Predisposing Factors in Singapore},

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}A Case Report-Primary Vaginismus: Predisposing Factors in Singapore









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	author = {Kevin Lee and Joseph Banta and Matthew D{\textquotesingle}Ambrosio and Apostolos Voudouris and Antonios Tsompanidis},

	title = {Years of palpitations and a heart rate of 213 beats per minute},

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}Lee_et_al-2017-Clinical_Case_Reports.pdf









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	author = {Amit Joshi and Abhay Joshi and Hiren Patel and Dovenia Ponnoth and Grazia Stagni},

	title = {Cutaneous Penetration{\textendash}Enhancing Effect of Menthol: Calcium Involvement},

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}





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	title = {Clinical Research: Good News Coming from {Ca\textsuperscript{2+}}/{cAMP} Signaling Interaction},

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}









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	volume = {88},

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	author = {Hai Huang and Michael K. Pugsley and Michael Accardi and Alexis Ascah and Roy Forster and Simon Authier},

	title = {Simple Quantitative Comparison of Multi-Ion Channel Inhibition Profiles},

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}1-s2.0-S1056871917303234-main.pdf









@article{Mart_nez_Delgado_2017,


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	publisher = {S. Karger {AG}},

	volume = {93},

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	author = {Gustavo Mart{\'{\i}}nez-Delgado and Ricardo Felix},

	title = {Emerging Role of Ca$\less$sub$\greater$V$\less$/sub$\greater$1.2 Channels in Proliferation and Migration in Distinct Cancer Cell Lines},

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}martnezdelgado2017.pdf









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	title = {Data visualization in an era of multi-ion channel inhibition strategies},

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}









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	title = {{Ca\textsuperscript{2+}} protein alpha 1D of {CaV}1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity},

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}









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}Abstract









@article{Zamponi_2017,


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}acschemneuro.7b00415.pdf









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	volume = {71},

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	author = {Olivier Bezen{\c{c}}on and Romain Siegrist and Bibia Heidmann and Davide Pozzi and Simon Stamm and Lubo{\v{s}} Reme{\v{n}} and Sylvia Richard and Lloyd Simons and Rick Gaston and Dennis Downing and Corinna Grisostomi and Catherine Roch and Melanie Kessler and John Gatfield and Richard Moon and Thomas Pfeifer and Johannes Mosbacher and Isabelle Reymond and Eric A. Ertel and Ruben de Kanter and Bruno Capeleto and Elvire Fournier and Markus Rey and Luca Moccia and Michael Toeroek-Schafroth and Ren{\'{e}} Roscher and Benno Schindelholz},

	title = {Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies},

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	title = {Ca v 1.2, but not Ca v 1.3, {L-type} calcium channel subtype mediates nicotine-induced conditioned place preference in miceo},

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}









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	author = {Zeeba D. Kabir and Arlene Mart{\'{\i}}nez-Rivera and Anjali M. Rajadhyaksha},

	title = {From Gene to Behavior: {L-type} Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms},

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@article{Walker2008SMN,

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pages={1411-4122},

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@article{Setola2007Axonal,

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@article{Meister2002SMN,

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pages={472-748},

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@article{Pellizzoni1999SMN,

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 volume={96},

 number={20},

pages={11167-11172},

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@article{Zhang2003Active,

 title={Active Transport of the Survival Motor Neuron Protein and the Role of Exon-7 in Cytoplasmic Localization},

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 journal={Journal of Neuroscience the Official Journal of the Society for Neuroscience},

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pages={6627-6637},

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}







@article{Le2005SMNDelta7,

 title={{SMN}$\Delta7$, the major product of the centromeric survival motor neuron ({SMN}2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length {SMN}.},

 author={Le TT; Pham LT; Butchbach ME; Zhang HL; Monani UR; Coovert DD; Gavrilina TO; Xing L; Bassell GJ; Burghes AH},

 journal={Human Molecular Genetics},

 volume={14},

 number={6},

pages={845-857},

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@article{Workman2009A,

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 author={Workman, E and Saieva, L and Carrel, T. L. and Crawford, T. O. and Liu, D. and Lutz, C and Beattie, C. E. and Pellizzoni, L and Burghes, A. H.},

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pages={1990-9914},

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@article{Friesen2001SMN,

 title={SMN, the Product of the Spinal Muscular Atrophy Gene, Binds Preferentially to Dimethylarginine-Containing Protein Targets},

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 author={Friesen, Westley J. and Paushkin, Sergey and Wyce, Anastasia and Massenet, Severine and Pesiridis, G. Scott and Duyne, Gregory Van and Rappsilber, Juri and Mann, Matthias and Dreyfuss, Gideon},

 journal={Molecular \& ~Cellular Biology},

 volume={21},

 number={24},

pages={8289-8300},

 year={2001},

}



@article{Chari2008An,

 title={An Assembly Chaperone Collaborates with the {SMN} Complex to Generate Spliceosomal SnRNPs},

 author={Chari, A and Golas, M. M. and Klingenh\"ager, M and Neuenkirchen, N and Sander, B and Englbrecht, C and Sickmann, A and Stark, H and Fischer, U},

 journal={Cell},

 volume={135},

 number={3},

pages={497-509},

 year={2008},

}









@article{Gunter2002Assisted,

 title={Assisted RNP assembly: {SMN} and PRMT5 complexes cooperate in the formation of spliceosomal U{snRNP}s},

 author={Gunter Meister, Utz Fischer},

 journal={Embo Journal},

 volume={21},

 number={21},

pages={5853-8563},

 year={2002},

}





@article{Battle2006The,

 title={The Gemin5 protein of the {SMN} complex identifies sn{RNA}s},

 author={Battle, Daniel J. and Lau, Chi Kong and Wan, Lili and Deng, Hongying and Lotti, Francesco and Dreyfuss, Gideon},

 journal={Molecular Cell},

 volume={23},

 number={2},

pages={273-729},

 year={2006},

}









@article{Shpargel2005Gemin,

 title={Gemin proteins are required for efficient assembly of {Sm}-class ribonucleoproteins.},

 author={Shpargel, Karl B. and Gall, Joseph G.},

 journal={Proceedings of the National Academy of Sciences of the United States of America},

 volume={102},

 number={48},

pages={17372-73717},

 year={2005},

}





@article{Friesen2000Specific,

 title={Specific sequences of the {Sm} and {Sm}-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product ({SMN}).},

 author={Friesen, W. J. and Dreyfuss, G},

 journal={Journal of Biological Chemistry},

 volume={275},

 number={34},

pages={26370-73625},

 year={2000},

}







@article{Brahms2001Symmetrical,

 title={Symmetrical dimethylation of arginine residues in spliceosomal {Sm} protein B/B' and the {Sm}-like protein {LSm4}, and their interaction with the {SMN} protein.},

 author={Brahms, H and Meheus, L and De, Brabandere V and Fischer, {U} and L\"uhrmann, R},

 journal={RNA},

 volume={7},

 number={11},

pages={1531-5142},

 year={2001},

}









@article{Narayanan2002SMN,

 title={{SMN}, the spinal muscular atrophy protein, forms a pre-import {snRNP} complex with Snurportin1 and importin β},

 author={Narayanan, Usha and Ospina, Jason K. and Frey, Mark R. and Hebert, Michael D. and Matera, A. Gregory},

 journal={Human Molecular Genetics},

 volume={11},

 number={15},

pages={1785-1795},

 year={2002},

}





@article{Terns2001Macromolecular,

 title={Macromolecular complexes: {SMN}-the master assembler.},

 author={Terns, Michael P and Terns, And Rebecca M},

 journal={Current Biology Cb},

 volume={11},

 number={21},

pages={862-684},

 year={2001},

}









@article{Khusial2005LSm,

 title={L{Sm} proteins form heptameric rings that bind to {RNA} via repeating motifs.},

 author={Khusial, P and Plaag, R and Zieve, G. W.},

 journal={Trends in Biochemical Sciences},

 volume={30},

 number={9},

pages={522-258},

 year={2005},

}





@article{He2000Functions,

 title={Functions of Lsm proteins in m{RNA} degradation and splicing.},

 author={He, W. and Parker, R},

 journal={Current Opinion in Cell Biology},

 volume={12},

 number={3},

pages={346-350},

 year={2000},

}





@article{Pillai2003Unique,

 title={Unique {Sm} core structure of U7 {snRNP}s: assembly by a specialized {SMN} complex and the role of a new component, Lsm11, in histone {RNA} processing.},

 author={Pillai, R. S. and Grimmler, M and Meister, G and Will, C. L. and L\"uhrmann, R and Fischer, {U} and Sch\"umperli, D},

 journal={Genes \& ~Development},

 volume={17},

 number={18},

pages={2321-2333},

 year={2003},

}









@article{Tharun2005Mutations,

 title={Mutations in the Saccharomyces cerevisiae LSM1 gene that affect m{RNA} decapping and 3' end protection.},

 author={Tharun, S and Muhlrad, D and Chowdhury, A and Parker, R},

 journal={Genetics},

 volume={170},

 number={1},

pages={33-46},

 year={2005},

}







@article{Di2009Dendritic,

 title={Dendritic L{Sm}1/CBP80-mRNPs mark the early steps of transport commitment and translational control.},

 author={Di, Penta A and Mercaldo, V and Florenzano, F and Munck, S and Ciotti, M. T. and Zalfa, F and Mercanti, D and Molinari, M and Bagni, C and Achsel, T},

 journal={Journal of Cell Biology},

 volume={184},

 number={3},

pages={423-435},

 year={2009},

}





@article{Gandini2008LSm4,

 title={L{Sm}4 associates with the plasma membrane and acts as a co-factor in cell volume regulation.},

 author={Gandini, R and Dossena, S and Vezzoli, V and Tamplenizza, M and Salvioni, E and Ritter, M and Paulmichl, M and Furst, J},

 journal={Cellular Physiology \& ~Biochemistry},

 volume={22},

 number={5-6},

pages={579-590},

 year={2008},

}





@article{Brody1999The,

 title={The Interactive Fly: gene networks, development and the Internet},

 author={Brody, Thomas},

 journal={Trends in Genetics},

 volume={15},

 number={8},

pages={333-334},

 year={1999},

}



@article{Hua2008Antisense,

 title={Antisense Masking of an hnRNP {A1/A2} Intronic Splicing Silencer Corrects SMN2 Splicing in Transgenic Mice},

 author={Hua, Y. and Vickers, T. A. and Okunola, H. L. and Bennett, C. F. and Krainer, A. R.},

 journal={American Journal of Human Genetics},

 volume={82},

 number={4},

 pages={834-848},

 year={2008},

}



@article{Rossoll2002Specific,

 title={Specific interaction of {SMN}, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for {SMN} in {RNA} processing in motor axons?},

 author={Rossoll, Wilfried and Kr\"{o}ning, Ann Kathrin and Ohndorf, Uta Maria and Steegborn, Clemens and Jablonka, Sibylle and Sendtner, Michael},

 journal={Human Molecular Genetics},

 volume={11},

 number={1},

pages={93-105},

 year={2002},

}







@article{Rossoll2003SMN,

 title={{SMN}, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of β-actin m{RNA} in growth cones of motoneurons},

 author={Rossoll, W and Jablonka, S and Andreassi, C and Kr\"{o}ning, A. K. and Karle, K and Monani, U. R. and Sendtner, M},

 journal={Journal of Cell Biology},

 volume={163},

 number={4},

pages={801-812},

 year={2003},

}





@article{Zhang2006Multiprotein,

 title={Multiprotein complexes of the survival of motor neuron protein {SMN} with Gemins traffic to neuronal processes and growth cones of motor neurons.},

 author={Zhang, H. and Xing, L. and Rossoll, W and Wichterle, H and Singer, R. H. and Bassell, G. J.},

 journal={Journal of Neuroscience the Official Journal of the Society for Neuroscience},

 volume={26},

 number={33},

pages={8622-6832},

 year={2006},

}





@article{Claus2005Fibroblast,

 title={Fibroblast growth factor-2(23) binds directly to the survival of motoneuron protein and is associated with small nuclear {RNA}s.},

 author={Claus, P and Bruns, A. F. and Grothe, C},

 journal={Biochemical Journal},

 volume={384},

 number={Pt 3},

pages={559-565},

 year={2005},

}





@article{Jones2001Direct,

 title={Direct interaction of the spinal muscular atrophy disease protein {SMN} with the small nucleolar {RNA}-associated protein fibrillarin.},

 author={Jones, K. W. and Gorzynski, K and Hales, C. M. and Fischer, {U} and Badbanchi, F and Terns, R. M. and Terns, M. P.},

 journal={Journal of Biological Chemistry},

 volume={276},

 number={42},

pages={38645-38651},

 year={2001},

}

 





@article{Piazzon2008In,

 title={In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein.},

 author={Piazzon, N and Rage, F and Schlotter, F and Moine, H and Branlant, C and Massenet, S},

 journal={Journal of Biological Chemistry},

 volume={283},

 number={9},

pages={5598-5610},

 year={2008},

}





@article{Mourelatos2001SMN,

 title={{SMN} interacts with a novel family of hnRNP and spliceosomal proteins},

 author={Mourelatos, Zissimos and Abel, Linda and Yong, Jeongsik and Kataoka, Naoyuki and Dreyfuss, Gideon},

 journal={Embo Journal},

 volume={20},

 number={19},

pages={5443-5452},

 year={2001},

}





@article{Sharma2005,

 year = {2005},

 publisher = {Elsevier {BV}},

 volume = {309},

 number = {1},

 pages = {185-197},

 author = {Aarti Sharma and Anja Lambrechts and Le thi Hao and Thanh T. Le and Caroline A. Sewry and Christophe Ampe and Arthur H.M. Burghes and Glenn E. Morris},

 title = {A role for complexes of survival of motor neurons ({{SMN}}) protein with gemins and profilin in neurite-like cytoplasmic extensions of cultured nerve cells},

 journal = {Experimental Cell Research}

}



@article{Pellizzoni2001A,

 title={A Functional Interaction between the Survival Motor Neuron Complex and {RNA} Polymerase II},

 author={Pellizzoni, L and Charroux, B and Rappsilber, J and Mann, M and Dreyfuss, G},

 journal={Journal of Cell Biology},

 volume={152},

 number={1},

pages={75-85},

 year={2001},

}



@article{Burghes1997When,

 title={When Is a Deletion Not a Deletion? When It Is Converted},

 author={Burghes, Arthur H. M.},

 journal={American Journal of Human Genetics},

 volume={61},

 number={1},

pages={9-15},

 year={1997},

}

@article{Campbell1997Genomic,

 title={Genomic variation and gene conversion in spinal muscular atrophy: implications for disease process and clinical phenotype.},

 author={Campbell, L and Potter, A and Ignatius, J and Dubowitz, V and Davies, K},

 journal={American Journal of Human Genetics},

 volume={61},

 number={1},

 pages={40-50},

 year={1997},

}



@article{Schrank1997Inactivation,

 title={Inactivation of the Survival Motor Neuron Gene, a Candidate Gene for Human Spinal Muscular Atrophy, Leads to Massive Cell Death in Early Mouse Embryos},

 author={Schrank, Bertold and Sendtner, Michael},

 journal={Proceedings of the National Academy of Sciences of the United States of America},

 volume={94},

 number={18},

pages={9920-2995},

 year={1997}

}



@article{Zerres1995Natural,

 title={Natural History in Proximal Spinal Muscular Atrophy: Clinical Analysis of 445 Patients and Suggestions for a Modification of Existing Classifications},

 author={Zerres, Klaus and Rudniksch\"{o}neborn, Sabine},

 journal={Archives of Neurology},

 volume={52},

 number={5},

pages={518-523},

 year={1995}

}







@article{Feldk2002Quantitative,

 title={Quantitative analyses of {SMN}1 and {SMN}2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy.},

 author={Feldk\"{o}tter, M and Schwarzer, V and Wirth, R and Wienker, T. F. and Wirth, B},

 journal={American Journal of Human Genetics},

 volume={70},

 number={2},

pages={358-368},

 year={2002},

}



@article{Mailman2002Molecular,

 title={Molecular analysis of spinal muscular atrophy and modification of the phenotype by {SMN}2.},

 author={Mailman, M. D. and Heinz, J. W. and Papp, A. C. and Snyder, P. J. and Sedra, M. S. and Wirth, B and Burghes, A. H. and Prior, T. W.},

 journal={Genetics in Medicine Official Journal of the American College of Medical Genetics},

 volume={4},

 number={1},

pages={20-26},

 year={2002},

}







@article{Monani1999Promoter,

 title={Promoter analysis of the human centromeric and telomeric survival motor neuron genes ({SMN}C and {SMN}T).},

 author={Monani, U. R. and Mcpherson, J. D. and Burghes, A. H.},

 journal={Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression},

 volume={1445},

 number={3},

pages={330-336},

 year={1999},

}



@article{A1999The,

 title={The promoters of the survival motor neuron gene ({SMN}) and its copy ({SMN}c) share common regulatory elements.},

 author={A Echaniz-Laguna, P Miniou, D Bartholdi, J Melki},

 journal={American Journal of Human Genetics},

 volume={64},

 number={5},

pages={1365-3170},

 year={1999},

}



@article{Lefebvre1997Correlation,

 title={Correlation between severity and {SMN} protein level in spinal muscular atrophy},


 journal={Nature Genetics},

 volume={16},

 number={3},

pages={265-629},

 year={1997},

}



@article{Man2008A,

 title={A two-site {ELISA} can quantify upregulation of {SMN} protein by drugs for spinal muscular atrophy.},

 author={Man, Nguyen Thi and Humphrey, E and Lam, L. T. and Fuller, H. R. and Lynch, T. A. and Sewry, C. A. and Goodwin, P. R. and Mackenzie, A. E. and Morris, G. E.},

 journal={Neurology},

 volume={71},

 number={71},

 pages={1757-1763},

 year={2008},

}



@article{Coovert1997The,

 title={The survival motor neuron protein in spinal muscular atrophy.},

 author={Coovert, D. D. and Le, T. T. and Mcandrew, P. E. and Strasswimmer, J and Crawford, T. O. and Mendell, J. R. and Coulson, S. E. and Androphy, E. J. and Prior, T. W. and Burghes, A. H.},

 journal={Human Molecular Genetics},

 volume={6},

 number={8},

pages={1205-2114},

 year={1997},

}





@article{Lorson1999A,

 title={A single nucleotide in the {SMN} gene regulates splicing and is responsible for spinal muscular atrophy.},

 author={Lorson, C. L. and Hahnen, E and Androphy, E. J. and Wirth, B},

 journal={Proceedings of the National Academy of Sciences},

 volume={96},

 number={11},

pages={6307-3611},

 year={1999},

}







@article{Kashima2003A,

 title={A negative element in {SMN}2 exon 7 inhibits splicing in spinal muscular atrophy.},

 author={Kashima, T and Manley, J. L.},

 journal={Nature Genetics},

 volume={34},

 number={4},

pages={460-643},

 year={2003},

}







@article{Lorson2000An,

 title={An exonic enhancer is required for inclusion of an essential exon in the {SMA}-determining gene {SMN}.},

 author={Lorson, C. L. and Androphy, E. J.},

 journal={Human Molecular Genetics},

 volume={9},

 number={2},

pages={259-265},

 year={2000},

}





@article{Burnett2009Regulation,

 title={Regulation of {SMN} protein stability.},

 author={Burnett, B. G. and Muñoz, E and Tandon, A and Kwon, D. Y. and Sumner, C. J. and Fischbeck, K. H.},

 journal={Molecular \& ~Cellular Biology},

 volume={29},

 number={5},

pages={1107-1115},

 year={2009},

}



@article{Sun2005Molecular,

 title={Molecular and functional analysis of intragenic {SMN}1 mutations in patients with spinal muscular atrophy.},

 author={Sun, Y. and Grimmler, M and Schwarzer, V and Schoenen, F and Fischer, {U} and Wirth, B},

 journal={Human Mutation},

 volume={25},

 number={1},

pages={64-71},

 year={2005},

}





@article{B1999Essential,

 title={Essential role for the {Tudor} romain of {SMN} in spliceosomal {U} {snRNP} assembly: implications for Spinal Muscular Atrophy},

 author={B\"uhler, Dirk and Raker, Veronica and L\"uhrmann, Reinhard and Fischer, Utz},

 journal={Human Molecular Genetics},

 volume={8},

 number={13},

pages={2351-5327},

 year={1999},

}





@article{Monani2003A,

 title={A transgene carrying an {A2G} missense mutation in the {SMN} gene modulates phenotypic severity in mice with severe (type {I}) spinal muscular atrophy.},

 author={Monani, U. R. and Pastore, M. T. and Gavrilina, T. O. and Jablonka, S and Le, T. T. and Andreassi, C and Dicocco, J. M. and Lorson, C and Androphy, E. J. and Sendtner, M},

 journal={Journal of Cell Biology},

 volume={160},

 number={1},

pages={41-52},

 year={2003},

}





@article{Ogawa2007Gemin2,

 title={Gemin2 plays an important role in stabilizing the survival of motor neuron complex.},

 author={Ogawa, C and Usui, K and Aoki, M and Ito, F and Itoh, M and Kai, C. and Kanamorikatayama, M and Hayashizaki, Y and Suzuki, H},

 journal={Journal of Biological Chemistry},

 volume={282},

 number={15},

pages={11122-11134},

 year={2007},

}





@article{Kotani2007A,

 title={A novel mutation at the N-terminal of {SMN} {Tudor} domain inhibits its interaction with target proteins.},

 author={Kotani, T and Sutomo, R and Sasongko, T. H. and Sadewa, A. H. and Gunadi and Minato, T and Fujii, E and Endo, S and Lee, M. J. and Ayaki, H},

 journal={Journal of Neurology},

 volume={254},

 number={5},

pages={624-630},

 year={2007},

}











@article{Parsons1998Intragenic,

 title={Intragenic tel{SMN} Mutations: Frequency, Distribution, Evidence of a Founder Effect, and Modification of the Spinal Muscular Atrophy Phenotype by cen{SMN} Copy Number},

 author={Parsons, D. W. and Mcandrew, P. E. and Iannaccone, S. T. and Mendell, J. R. and Burghes, A. H. M. and Prior, T. W.},

 journal={American Journal of Human Genetics},

 volume={63},

 number={6},

pages={1712-7123},

 year={1998},

}







@article{Francesca2006Ribonucleoprotein,

 title={Ribonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal {{snRNP}s}.},

 author={Francesca, Gabanella and Butchbach, Matthew E R, and Luciano, Saieva and Claudia, Carissimi and Burghes, Arthur H M, and Livio, Pellizzoni},

 journal={Plos One},

 volume={e921},

 number={9},

pages={1-12},

 year={2006},

}





@article{Owen2000Characterization,

 title={Characterization of the Schizosaccharomyces pombe orthologue of the human survival motor neuron ({SMN}) protein.},

 author={Owen, N and Doe, C. L. and Mellor, J and Davies, K. E.},

 journal={Human Molecular Genetics},

 volume={9},

 number={5},

pages={675-684},

 year={2000},

}




@article{Paushkin2000The,

 title={The survival motor neuron protein of \textit{Schizosacharomyces pombe}. Conservation of survival motor neuron interaction domains in divergent organisms.},

 author={Paushkin, S and Charroux, B and Abel, L and Perkinson, R. A. and Pellizzoni, L and Dreyfuss, G},

 journal={Journal of Biological Chemistry},

 volume={275},

 number={31},

pages={23841-48326},

 year={2000},

}



@article{Monani2000The,

 title={The human centromeric survival motor neuron gene ({SMN}2) rescues embryonic lethality in {SMN}	\textsuperscript{-}/\textsuperscript{-} mice and results in a mouse with spinal muscular atrophy},

 author={Monani, Umrao R. and Sendtner, Michael and Coovert, Daniel D. and Parsons, D. William and Andreassi, Catia and Le, Thanh T. and Jablonka, Sibylle and Schrank, Berthold and Rossol, Wilfred and Prior, Thomas W.},

 journal={Human Molecular Genetics},

 volume={9},

 number={3},

pages={333-339},

 year={2000},

}





@article{Miguel1999The,

 title={The \textit{Caenorhabditis Elegans} orthologue of the human gene responsible for spinal muscular atrophy is a maternal product critical for germline maturation and embryonic viability},

 author={Miguel-Aliaga, Irene and Culetto, Emmanuel and Walker, Denise S. and Baylis, Howard A. and Sattelle, David B. and Davies, Kay E.},

 journal={Human Molecular Genetics},

 volume={8},

 number={12},

pages={2133-1243},

 year={1999},

}





@article{Chan2003Neuromuscular,

 title={Neuromuscular defects in a {Drosophila} survival motor neuron gene mutant.},

 author={Chan, Yick Bun and Miguelaliaga, Irene and Franks, Chris and Thomas, Natasha and Tr\"ulzsch, Barbara and Sattelle, David B. and Davies, Kay E. and Heuvel, Marcel Van Den},

 journal={Human Molecular Genetics},

 volume={12},

 number={12},

pages={1367-3176},

 year={2003},

}





@article{Mcwhorter2003Knockdown,

 title={Knockdown of the survival motor neuron ({SMN}) protein in zebrafish causes defects in motor axon outgrowth and pathfinding.},

 author={Mcwhorter, M. L. and Monani, U. R. and Burghes, A. H. and Beattie, C. E.},

 journal={Journal of Cell Biology},

 volume={162},

 number={5},

pages={919-931},

 year={2003},

}







@article{Frugier2000Nuclear,

 title={Nuclear targeting defect of {SMN} lacking the C-terminus in a mouse model of spinal muscular atrophy},

 author={Frugier, T and Tiziano, F. D. and Cifuentes-Diaz, C and Miniou, P and Roblot, N and Dierich, A and Le, Meur M and Melki, J},

 journal={Human Molecular Genetics},

 volume={9},

 number={5},

pages={849-858},

 year={2000},

}





@article{Hannus2000The,

 title={The Schizosaccharomyces pombe protein Yab8p and a novel factor, Yip1p, share structural and functional similarity with the spinal muscular atrophy-associated proteins {SMN} and SIP1.},

 author={Hannus, S and B\"uhler, D and Romano, M and Seraphin, B and Fischer, U},

 journal={Human Molecular Genetics},

 volume={9},

 number={5},

pages={663-674},

 year={2000},

}



@article{Briese2009Deletion,

 title={Deletion of \textit{Smn-1}, the Caenorhabditis elegans ortholog of the spinal muscular atrophy gene, results in locomotor dysfunction and reduced lifespan.},

 author={Briese, M and Esmaeili, B and Fraboulet, S and Burt, E. C. and Christodoulou, S and Towers, P. R. and Davies, K. E. and Sattelle, D. B.},

 journal={Human Molecular Genetics},

 volume={18},

 number={1},

pages={97-104},

 year={2009},

}



@article{Cifuentesdiaz2001Deletion,

 title={Deletion of murine {SMN} exon 7 directed to skeletal muscle leads to severe muscular dystrophy},

 author={Cifuentesdiaz, Carmen and Frugier, Tony and Tiziano, Francesco D. and Lacène, Emmanuelle and Roblot, Natacha and Joshi, Vandana and Moreau, Marie Helene and Melki, Judith},

 journal={Journal of Cell Biology},

 volume={152},

 number={5},

pages={1107-1114},

 year={2001},

}





@article{Vitte2004Deletion,

 title={Deletion of murine {SMN} exon 7 directed to liver leads to severe defect of liver development associated with iron overload.},

 author={Vitte, J. M. and Davoult, B and Roblot, N and Mayer, M and Joshi, V and Courageot, S and Tronche, F and Vadrot, J and Moreau, M. H. and Kemeny, F},

 journal={American Journal of Pathology},

 volume={165},

 number={5},

pages={1731-7141},

 year={2004},

}





@article{Gavrilina2008Neuronal,

 title={Neuronal {SMN} expression corrects spinal muscular atrophy in severe {SMA} mice while muscle-specific {SMN} expression has no phenotypic effect},

 author={Gavrilina, Tatiana O. and Mcgovern, Vicki L. and Workman, Eileen and Crawford, Thomas O. and Gogliotti, Rocky G. and Didonato, Christine J. and Monani, Umrao R. and Morris, Glenn E. and Burghes, Arthur H. M.},

 journal={Human Molecular Genetics},

 volume={17},

 number={8},

pages={1063-0175},

 year={2008},

}





@article{Didonato2001Regulation,

 title={Regulation of murine survival motor neuron (SMN) protein levels by modifying {SMN} exon 7 splicing.},

 author={Didonato, C. J. and Lorson, C. L. and De, Repentigny Y. and Simard, L. and Chartrand, C. and Androphy, E. J. and Kothary, R.},

 journal={Human Molecular Genetics},

 volume={10},

 number={23},

pages={2727-7236},

 year={2001},

}







@article{Briese2006SMN,

 title={{SMN}, the product of the spinal muscular atrophy-determining gene, is expressed widely but selectively in the developing human forebrain.},

 author={Briese, M and Richter, D. U. and Sattelle, D. B. and Ulfig, N},

 journal={Journal of Comparative Neurology},

 volume={497},

 number={5},

pages={808-816},

 year={2006},

}





@article{Kariya2008Reduced,

 title={Reduced {SMN} protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy.},

 author={Kariya, S and Park, G. H. and Maeno-Hikichi, Y and Leykekhman, O and Lutz, C and Arkovitz, M. S. and Landmesser, L. T. and Monani, U. R.},

 journal={Human Molecular Genetics},

 volume={17},

 number={16},

pages={2552-5269},

 year={2008},

}





@article{Swoboda2005Natural,

 title={Natural history of denervation in {SMA}: relation to age, {SMN}2 copy number, and function.},

 author={Swoboda, K. J. and Prior, T. W. and Scott, C. B. and Mcnaught, T. P. and Wride, M. C. and Reyna, S. P. and Bromberg, M. B.},

 journal={Annals of Neurology},

 volume={57},

 number={5},

pages={704-712},

 year={2005},

}





@article{Wan2005The,

 title={The survival of motor neurons protein determines the capacity for {snRNP} assembly: Biochemical deficiency in spinal muscular atrophy},

 author={Wan, L. and Battle, D. J. and Yong, J. and Gubitz, A. K. and Kolb, S. J. and Wang, J. and Dreyfuss, G},

 journal={Molecular \& ~Cellular Biology},

 volume={25},

 number={13},

pages={5543-5551},

 year={2005},

}

























@article{Gabanella2005The,

 title={The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation},

 author={Gabanella, Francesca and Carissimi, Claudia and Usiello, Alessandro and Pellizzoni, Livio},

 journal={Human Molecular Genetics},

 volume={14},

 number={23},

pages={3629-6342},

 year={2005},

}













@article{Grimmler2005Phosphorylation,

 title={Phosphorylation regulates the activity of the {SMN} complex during assembly of spliceosomal {U} {snRNP}s},

 author={Grimmler, M and Bauer, L and Nousiainen, M and K\"{o}rner, R and Meister, G and Fischer, U},

 journal={EMBO reports},

 volume={6},

 number={1},

pages={70-76},

 year={2005},

}



@article{Winkler2005Reduced,

 title={Reduced {U} {snRNP} assembly causes motor axon degeneration in an animal model for spinal muscular atrophy},

 author={Winkler, C and Eggert, C and Gradl, D and Meister, G and Giegerich, M and Wedlich, D and Laggerbauer, B and Fischer, U},

 journal={Genes \& ~Development},

 volume={19},

 number={19},

pages={2320-3230},

 year={2005},

}



@article{Michelle2008The,

 title={The {SMN} binding protein gemin2 is not involved in motor axon outgrowth},

 author={Michelle L. McWhorter and Boon, Kum Loong and Horan, Erin S. and Burghes, Arthur H. M. and Beattie, Christine E.},

 journal={Developmental Neurobiology},

 volume={68},

 number={2},

pages={182-194},

 year={2008},

}









@article{Lee2008Genome,

 title={Genome-Wide expression analysis of a spinal muscular atrophy model: towards discovery of new drug targets},

 author={Lee, S and Sayin, A and Cauchi, R. J. and Grice, S and Burdett, H and Baban, D and Van, den Heuvel M},

 journal={Plos One},

 volume={e1404},

 number={1},

pages={1-11},

 year={2008},

}









@article{Jedrzejowska2008Unaffected,

 title={Unaffected patients with a homozygous absence of the {SMN}1 gene.},

 author={Jedrzejowska, M and Borkowska, J and Zimowski, J and Kosterapruszczyk, A and Milewski, M and Jurek, M and Sielska, D and Kostyk, E and Nyka, W and Zaremba, J},

 journal={European Journal of Humangenetics},

 volume={16},

 number={8},

pages={930-394},

 year={2008},

}





@article{Gonsalvez2008Sm,

 title={{Sm} protein methylation is dispensable for {snRNP} assembly in \textit{{Drosophila} melanogaster}.},

 author={Gonsalvez, G. B. and Praveen, K and Hicks, A. J. and Tian, L. and Matera, A. G.},

 journal={RNA},

 volume={14},

 number={5},

pages={878-887},

 year={2008},

}





@article{Gonsalvez2007Two,

 title={Two distinct arginine methyltransferases are required for biogenesis of {Sm}-class ribonucleoproteins.},

 author={Gonsalvez, G. B. and Tian, L. and Ospina, J. K. and Boisvert, F. M. and Lamond, A. I. and Matera, A. G.},

 journal={Journal of Cell Biology},

 volume={178},

 number={5},

pages={733-740},

 year={2007},

}







@article{Giesemann1999A,

 title={A role for polyproline motifs in the spinal muscular atrophy protein {SMN}. Profilins bind to and colocalize with smn in nuclear gems.},

 author={Giesemann, T and Rathkehartlieb, S and Rothkegel, M and Bartsch, J. W. and Buchmeier, S and Jockusch, B. M. and Jockusch, H},

 journal={Journal of Biological Chemistry},

 volume={274},

 number={53},

pages={37908-97314},

 year={1999},

}





@article{Talbot1997Missense,

 title={Missense mutation clustering in the survival motor neuron gene: a role for a conserved tyrosine and glycine rich region of               the protein in {RNA} metabolism?},

 author={Talbot, Kevin and Ponting, Christopher P. and Theodosiou, Aspasia M. and Rodrigues, Nanda R. and Surtees, Robert and Mountford, Roger and Davies, Kay E.},

 journal={Human Molecular Genetics},

 volume={6},

 number={3},

pages={497-500},

 year={1997},

}



@article{Sossi2001Premature,

 title={Premature termination mutations in exon 3 of the SMN1 gene are associated with exon skipping and a relatively mild SMA phenotype.},

 author={Sossi, V and Giuli, A and Vitali, T and Tiziano, F and Mirabella, M and Antonelli, A and Neri, G and Brahe, C},

 journal={European Journal of Human Genetics Ejhg},

 volume={9},

 number={2},

 pages={113-120},

 year={2001},

}



@article{Prior2007Spinal,

 title={Spinal muscular atrophy diagnostics.},

 author={Prior, T. W.},

 journal={Journal of Child Neurology},

 volume={22},

 number={8},

pages={952-956},

 year={2007},

}

@article{Zabnenkova2015,

 title={SMN1 Gene Point Mutations in Type I-IV Proximal Spinal Muscular Atrophy Patients with a Single Copy of {SMN1}.},

 author={Zabnenkova, V. V. and Dadali, E. L. and Artemieva, S. B. and Sharkova, I. V. and Rudenskaya, G. E. and Polyakov, A. V.},

 journal={Russian Journal of Genetics},

 volume={51},

 number={9},

 pages={1075-1082},

 year={2015},

}



@article{Bai2014Subtle,

 title={Subtle mutation detection of {SMN1} gene in Chinese spinal muscular atrophy patients: implication of molecular diagnostic procedure for {SMN1} gene mutations.},

 author={Bai, J. L. and Qu, Y. J. and Cao, Y. Y. and Li, E. Z. and Wang, L. W. and Li, Y. and Zhu, Y. L. and Zhang, W. H. and Jin, Y. W. and Wang, H.},

 journal={Genetic Testing \& Molecular Biomarkers},

 volume={18},

 number={8},

 pages={546-551},

 year={2014},

}



@article{Wirth2000An,

 title={An update of the mutation spectrum of the survival motor neuron gene \textit{SMN1} in autosomal recessive spinal muscular atrophy (SMA)},

 author={Wirth, Brunhilde},

 journal={Human Mutation},

 volume={15},

 number={3},

 pages={228-237},

 year={2000},

}



@article{Hahnen1997Missense,

 title={Missense mutations in exon 6 of the survival motor neuron gene in patients with spinal muscular atrophy ({SMA}).},

 author={Hahnen, E and Sch\"{o}nling, J and Rudnik-Sch\"{o}neborn, S and Raschke, H and Zerres, K and Wirth, B},

 journal={Human Molecular Genetics},

 volume={6},

 number={5},

pages={821-285},

 year={1997},

}

@article{Tsai2001Molecular,

 title={Molecular analysis of SMN, NAIP and P44 genes of SMA patients and their families.},

 author={Tsai, C and Jong, Y and Hu, C and Chen, C and Shih, M and Chang, C and Chang, J},

 journal={Journal of the Neurological Sciences},

 volume={190},

 number={2},

 pages={35-40},

 year={2001},

}

@article{Brichta2008Nonsense,

 title={Nonsense-mediated messenger RNA decay of survival motor neuron 1 causes spinal muscular atrophy},

 author={Brichta, Lars and Garbes, Lutz and Jedrzejowska, Maria},

 journal={Human Genetics},

 volume={123},

 number={2},

 pages={141-153},

 year={2008},

}





@article{Wang1998Identification,

 title={Identification of a novel missense mutation of the {SMN}\textsuperscript{T} gene in two siblings with spinal muscular atrophy.},

 author={Wang, C. H. and Papendick, B. D. and Bruinsma, P and Day, J. K.},

 journal={neurogenetics},

 volume={1},

 number={4},

pages={273-276},

 year={1998},

}







@article{Burt2006Caenorhabditis,

 title={Caenorhabditis elegans in the study of {SMN}-interacting proteins: a role for SMI-1, an orthologue of human Gemin2 and the identification of novel components of the {SMN} complex},

 author={Burt, Emma C. and Towers, Paula R. and Sattelle, David B.},

 journal={Invertebrate Neuroscience},

 volume={6},

 number={4},

pages={145-159},

 year={2006},

}









@article{Rajendra2007A,

 title={A {Drosophila} melanogaster model of spinal muscular atrophy reveals a function for {SMN} in striated muscle},

 author={Rajendra, T. K. and Matera, A. Gregory},

 journal={Journal of Cell Biology},

 volume={176},

 number={6},

pages={831-841},

 year={2007},

}



@article{Zapletalov2007Analysis,

 year = {2007},

 publisher = {Elsevier {BV}},

 volume = {17},

 number = {6},

 pages = {476-481},

 author = {Eva Zapletalov{\'{a}} and Petra Hedvi{\v{c}}{\'{a}}kov{\'{a}} and Libor Koz{\'{a}}k and Petr Vondr{\'{a}}{\v{c}}ek and Renata Gaillyov{\'{a}} and Tat'{\'{a}}na Ma{\v{r}}{\i}{\textasciiacute}kov{\'{a}} and Zden{\v{e}}k Kalina and V{\v{e}}ra J\"{u}ttnerov{\'{a}} and Ji{\v{r}}{\i}{\textasciiacute} Fajkus and Lenka Fajkusov{\'{a}}},

 title = {Analysis of point mutations in the {SMN}1 gene in {SMA} patients bearing a single {SMN}1 copy},

 journal = {Neuromuscular Disorders}

}







@article{Martin2012The,

 title={The Survival Motor Neuron protein forms soluble glycine zipper oligomers},

 author={Martin, Renee and Gupta, Kushol and Ninan, Nisha S. and Perry, Kay and Duyne, Gregory D. Van},

 journal={Structure},

 volume={20},

 number={11},

 pages={1929-1939},

 year={2012},

}

@article{Tripsianes2011Structural,

 title={Structural basis for dimethylarginine recognition by the {Tudor} domains of human {SMN} and SPF30 proteins.},

 author={Tripsianes, K and Madl, T and Machyna, M and Fessas, D and Englbrecht, C and Fischer, {U} and Neugebauer, K. M. and Sattler, M},

 journal={Nature Structural \& ~Molecular Biology},

 volume={18},

 number={12},

 pages={1414-1420},

 year={2011},

}







@article{Zhang2011Structure,

 title={Structure of a key intermediate of the {SMN} complex reveals Gemin2's crucial function in {snRNP} assembly.},

 author={Zhang, R. and So, B. R. and Li, P. and Yong, J. and Glisovic, T and Wan, L. and Dreyfuss, G},

 journal={Cell},

 volume={146},

 number={3},

pages={384-395},

 year={2011},

}











@article{Hua2010Antisense,

 title={Antisense correction of {SMN}2 splicing in the CNS rescues necrosis in a type III {SMA} mouse model},

 author={Hua, Y. and Sahashi, K and Hung, G and Rigo, F and Passini, M. A. and Bennett, C. F. and Krainer, A. R.},

 journal={Genes \& ~Development},

 volume={24},

 number={15},

pages={1634-6144},

 year={2010},

}







@article{Carrel2006Survival,

 title={Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis.},

 author={Carrel, T. L. and Mcwhorter, M. L. and Workman, E and Zhang, H. and Wolstencroft, E. C. and Lorson, C and Bassell, G. J. and Burghes, A. H. and Beattie, C. E.},

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 volume={26},

 number={43},

pages={11014-01122},

 year={2006},

}





@article{Jr2009Delivery,

 title={Delivery of recombinant follistatin lessens disease severity in a mouse model of spinal muscular atrophy},

 author={Jr, Ferrill F. Rose, and Mattis, Virginia B. and Rindt, Hansj\"{o}rg and Lorson, Christian L.},

 journal={Human Molecular Genetics},

 volume={18},

 number={6},

 pages={997-1005},

 year={2009},

}

@article{Hua2011Peripheral,

 title={Peripheral {{SMN}} restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model},

 author={Hua, Y. and Sahashi, K and Rigo, F and Hung, G and Horev, G and Bennett, C. F. and Krainer, A. R.},

 journal={Nature},

 volume={478},

 number={7367},

pages={123-216},

 year={2011},

}




@article{Grimm2013Structural,

 title={Structural basis of assembly chaperone-mediated {snRNP} formation.},

 author={Grimm, C and Chari, A and Pelz, J. P. and Kuper, J and Kisker, C and Diederichs, K and Stark, H and Schindelin, H and Fischer, U},

 journal={Molecular Cell},

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pages={692-703},

 year={2013},

}







@article{Tarahovsky2012Calcium,

 title={Calcium-dependent aggregation and fusion of phosphatidylcholine liposomes induced by complexes of flavonoids with divalent iron},

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 year={2012},

 publisher={Elsevier}

}

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 journal={Biochim. Biophys. Acta},

 volume={1848},

 number={1},

 pages={289-298},

 year={2014},

 publisher={Elsevier}

}

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 publisher={ASBMB}

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 year={2002},

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}





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 title={Characterization of human saposins by NMR spectroscopy},

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 year={2006},

 publisher={ACS Publications}

}

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 journal={FASEB J.},

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 pages={4236-4247},

 year={2015},

 publisher={FASEB}

}

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 title={{Structure of human saposin A at lysosomal pH}},

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 volume={71},

 pages={895-900},

 year={2015},

 publisher={International Union of Crystallography}

}

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 title={{Oscillatory transepithelial $H^{+}$ flux regulates a rhythmic behavior in \textit{C. elegans}}},

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 volume={18},

 pages={297-302},

 year={2008},

 publisher={Elsevier}

}

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 title={Crystal structure of saposin B reveals a dimeric shell for lipid binding},

 author={Ahn, Victoria E and Faull, Kym F and Whitelegge, Julian P and Fluharty, Arvan L and Priv{\'e}, Gilbert G},

 journal={Proc. Natl. Acad. Sci. USA},

 volume={100},

 pages={38-43},

 year={2003},

 publisher={National Acad Sciences}

}

@article{popovic2012structure,

 title={Structure of saposin A lipoprotein discs},

 author={Popovic, Konstantin and Holyoake, John and Pom{\`e}s, R{\'e}gis and Priv{\'e}, Gilbert G},

 journal={Proc. Natl. Acad. Sci. USA},

 volume={109},

 pages={2908-2912},

 year={2012},

 publisher={National Acad Sciences}

}

@article{andra2003amoebapores,

 title={Amoebapores, archaic effector peptides of protozoan origin, are discharged into phagosomes and kill bacteria by permeabilizing their membranes},

 author={Andr{\"a}, J{\"o}rg and Herbst, Rosa and Leippe, Matthias},

 journal={Dev. Comp. Immunol.},

 volume={27},

 pages={291-304},

 year={2003},

 publisher={Elsevier}

}

@article{bulet2004anti,

 title={Anti-microbial peptides: from invertebrates to vertebrates},

 author={Bulet, Philippe and St{\"o}cklin, Reto and Menin, Laure},

 journal={Immunol. Rev.},

 volume={198},

 pages={169-184},

 year={2004},

 publisher={Wiley Online Library}

}

@article{bhattacharyya2004disulfide,

 title={Disulfide bonds, their stereospecific environment and conservation in protein structures},

 author={Bhattacharyya, Rajasri and Pal, Debnath and Chakrabarti, Pinak},

 journal={Protein Eng. Des. Sel.},

 volume={17},

 pages={795-808},

 year={2004},

 publisher={Oxford Univ Press}

}

@article{xu2011improving,

 title={Improving the physical realism and structural accuracy of protein models by a two-step atomic-level energy minimization},

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 journal={Biophys. J.},

 volume={101},

 pages={2525-2534},

 year={2011},

 publisher={Elsevier}

}



@article{delano2002pymol,

 title={Pymol: An open-source molecular graphics tool},

 author={DeLano, Warren L},

 journal={CCP4 Newsletter On Protein Crystallography},

 volume={40},

 pages={82-92},

 year={2002}

}



@article{tosatto2005victor,

 title={{The VICTOR Package for 3D protein structure modelling}},

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 volume={12},

 pages={1316-1327},

 year={2005}

}

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 title={Chemical Synthesis of A Pore-Forming Antimicrobial Protein, Caenopore-5, by Using Native Chemical Ligation at a Glu-Cys Site},

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 journal={ChemBioChem},

 volume={16},

 pages={328-336},

 year={2015},

 publisher={Wiley Online Library}

}

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 title={Microfluidic methods for forming liposomes},

 author={van Swaay, Dirk},

 journal={Lab. Chip.},

 volume={13},

 pages={752-767},

 year={2013},

 publisher={Royal Society of Chemistry}

}

@article{winau2004saposin,

 title={{Saposin C is required for lipid presentation by human CD1b}},

 author={Winau, Florian and Schwierzeck, Vera and Hurwitz, Robert and Remmel, Natascha and Sieling, Peter A and Modlin, Robert L and Porcelli, Steven A and Brinkmann, Volker and Sugita, Masahiko and Sandhoff, Konrad and others},

 journal={Nat. Immunol.},

 volume={5},

 pages={169-174},

 year={2004},

 publisher={Nature Publishing Group}

}

@article{sievers2011fastomega,

 title={{Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega}},

 author={Sievers, Fabian and Wilm, Andreas and Dineen, David and Gibson, Toby J and Karplus, Kevin and Li, Weizhong and Lopez, Rodrigo and McWilliam, Hamish and Remmert, Michael and S{\"o}ding, Johannes},

 journal={Molecular Systems Biology.},

 volume={7},

 pages={539-543},

 year={2011},

 publisher={EMBO Press}

}

@book{patterson2007physical,

 title={{Physical chemistry of macromolecules}},

 author={Patterson, Gary},

 year={2007},

 publisher={CRC Press}

}

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 title={{The CCPN data model for NMR spectroscopy: development of a software pipeline}},

 author={Vranken, Wim F and Boucher, Wayne and Stevens, Tim J and Fogh, Rasmus H and Pajon, Anne and Llinas, Miguel and Ulrich, Eldon L and Markley, John L and Ionides, John and Laue, Ernest D},

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 volume={59},

 pages={687-696},

 year={2005},

 publisher={Wiley Online Library}

}



@article{humphrey1996vmd,

 title={VMD: visual molecular dynamics},

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 pages={33-38},

 year={1996},

 publisher={Elsevier}

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@incollection{DHALLA2001,
 year = {2001},
 publisher = {Elsevier},
 pages = {949-965},
 author = {Naranjan S. Dhalla and Rana M. Temsah and Thomas Netticadan and Manjot S. Sandhu},
 title = {Calcium Overload in Ischemia/Reperfusion Injury},
 booktitle = {Heart Physiology and Pathophysiology}
}


@article{Xiong2002,
	author = {Xiong, Jian-Ping and Stehle, Thilo and Zhang, Rongguang and Joachimiak, Andrzej and Frech, Matthias and Goodman, Simon L. and Arnaout, M. Amin},
	title={{Crystal} structure of the extracellular segment of integrin \textalpha{V}\textbeta\textsubscript{3} in complex with an {Arg-Gly-Asp ligand}},
	volume = {296},
	number = {5565},
	pages = {151-155},
	year = {2002},
	publisher = {American Association for the Advancement of Science},
	abstract = {The structural basis for the divalent cation{\textendash}dependent binding of heterodimeric αβ integrins to their ligands, which contain the prototypical Arg-Gly-Asp sequence, is unknown. Interaction with ligands triggers tertiary and quaternary structural rearrangements in integrins that are needed for cell signaling. Here we report the crystal structure of the extracellular segment of integrin αVβ3 in complex with a cyclic peptide presenting the Arg-Gly-Asp sequence. The ligand binds at the major interface between the αV and β3 subunits and makes extensive contacts with both. Both tertiary and quaternary changes are observed in the presence of ligand. The tertiary rearrangements take place in βA, the ligand-binding domain of β3; in the complex, βA acquires two cations, one of which contacts the ligand Asp directly and the other stabilizes the ligand-binding surface. Ligand binding induces small changes in the orientation of αV relative to β3.},
	journal = {Science}
}




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@article{jancic2012low,

 title={{Low extracellular pH stimulates the production of IL-1$\beta$ by human monocytes}},

 author={Jancic, Carolina Cristina and Cabrini, Mercedes and Gabelloni, Mar{\'\i}a Laura and Rodrigues, Christian Rodr{\'\i}guez and Salamone, Gabriela and Trevani, Anal{\'\i}a Silvina and Geffner, Jorge},

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 pages={258-268},

 year={2012},

 publisher={Elsevier}

}

@article{einsfeldt2011cloning,

 title={{Cloning and expression of protease ClpP from Streptococcus pneumoniae in \textit{\textit{Escherichia coli}}}: Study of the influence of kanamycin and IPTG concentration on cell growth, recombinant protein production and plasmid stability},

 author={Einsfeldt, Karen and J{\'u}nior, Jo{\~a}o Baptista Severo and Argondizzo, Ana Paula Corr{\^e}a and Medeiros, Marco Alberto and Alves, Tito L{\'\i}vio Moitinho and Almeida, Rodrigo Volcan and Larentis, Ariane Leites},

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}

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 title={{Protein production by auto-induction in high-density shaking cultures}},

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 pages={207-234},

 year={2005},

 publisher={Elsevier}

}

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 title={{Membrane pores induced by magainin}},

 author={Ludtke, Steve J and He, Ke and Heller, William T and Harroun, Thad A and Yang, Lin and Huang, Huey W},

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 pages={13723-13728},

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