Version 1
: Received: 11 April 2020 / Approved: 12 April 2020 / Online: 12 April 2020 (05:36:40 CEST)
How to cite:
Neogi, U.; Hill, K. J.; Ambikan, A. T.; Heng, X.; Quinn, T. P.; Byrareddy, S. N.; Sönnerborg, A.; Sarafianos, S. G.; Singh, K. Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs. Preprints2020, 2020040184. https://doi.org/10.20944/preprints202004.0184.v1
Neogi, U.; Hill, K. J.; Ambikan, A. T.; Heng, X.; Quinn, T. P.; Byrareddy, S. N.; Sönnerborg, A.; Sarafianos, S. G.; Singh, K. Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs. Preprints 2020, 2020040184. https://doi.org/10.20944/preprints202004.0184.v1
Neogi, U.; Hill, K. J.; Ambikan, A. T.; Heng, X.; Quinn, T. P.; Byrareddy, S. N.; Sönnerborg, A.; Sarafianos, S. G.; Singh, K. Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs. Preprints2020, 2020040184. https://doi.org/10.20944/preprints202004.0184.v1
APA Style
Neogi, U., Hill, K. J., Ambikan, A. T., Heng, X., Quinn, T. P., Byrareddy, S. N., Sönnerborg, A., Sarafianos, S. G., & Singh, K. (2020). Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs. Preprints. https://doi.org/10.20944/preprints202004.0184.v1
Chicago/Turabian Style
Neogi, U., Stefan G. Sarafianos and Kamal Singh. 2020 "Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs" Preprints. https://doi.org/10.20944/preprints202004.0184.v1
Abstract
Coronaviruses (CoVs) are positive-stranded RNA viruses that infect humans and animals. Infection by CoVs such as HCoV-229E, -NL63, -OC43 and -HKUI1 leads to the common cold, short lasting rhinitis, cough, sore throat and fever. However, CoVs such as Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and the newest SARS-CoV-2 (the causative agent of COVID-19) lead to severe and deadly diseases with mortality rates ranging between ~1 to 35% depending on factors such as age and pre-existing conditions. Despite continuous global health threats to human, there are no approved vaccines or drugs targeting human CoVs, and the recent outbreak of COVID-19 emphasizes an urgent need for therapeutic interventions. Using computational and bioinformatics tools, here we present the feasibility of reported broad-spectrum RNA polymerase inhibitors as anti- SARS-CoV-2 drugs targeting its main RNA polymerase, suggesting that investigational and approved nucleoside RNA polymerase inhibitors have potential as anti-SARS-CoV-2 drugs. However, we note that it is also possible for SARS-CoV-2 to evolve and acquire drug resistance mutations against these nucleoside inhibitors.
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.