Concept Paper
Version 1
Preserved in Portico This version is not peer-reviewed
Feline Infectious Peritonitis: Challenges and Promises of Coronavirus RNA Detection
Version 1
: Received: 11 December 2020 / Approved: 14 December 2020 / Online: 14 December 2020 (13:27:55 CET)
How to cite: Kapulkin, W.; Kita, P. Feline Infectious Peritonitis: Challenges and Promises of Coronavirus RNA Detection. Preprints 2020, 2020120337. https://doi.org/10.20944/preprints202012.0337.v1 Kapulkin, W.; Kita, P. Feline Infectious Peritonitis: Challenges and Promises of Coronavirus RNA Detection. Preprints 2020, 2020120337. https://doi.org/10.20944/preprints202012.0337.v1
Abstract
Our perspective article covers major findings concerning Feline Infectious Peritonitis (FIP) - a fatal coronaviral disease of cats. In the context of FIP pathogenesis, we outline disease signalment and focus on the challenges and promises of FIP invoking coronavirus RNA detection. In particular, we outline critical aspects of coronavirus RNA replication and biogenesis. We infer the replicative intermediates of feline coronavirus may constitute an underappreciated factor triggering the progression of the maladaptive immune response underlying FIP pathogenesis.
Supplementary and Associated Material
https://figshare.com/articles/journal_contribution/Untitled_ItemMagazyn_Weterynaryjny_2000_supl_5_19-21/13281497: Figures Magazyn_Weterynaryjny_2000_supl_5_19-21
Keywords
Feline Infectious Peritonitis (FIP); coronavirus; dsRNA
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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