Transporters Beam Signals from Cell Membranes

Milica Ristovski; Danny Farhat; Shelly Bancud; Jyh-Yeuan Lee

doi:10.20944/preprints202107.0244.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 9 July 2021 / Approved: 12 July 2021 / Online: 12 July 2021 (11:24:18 CEST)

Lipid composition in the cellular membranes plays an important role in maintaining the struc-tural integrity of cells and in regulating cellular signaling that controls functions of both mem-brane-anchored and cytoplasmic proteins. ATP-dependent ABC and P4-ATPase lipid transport-ers, two integral membrane proteins, are known to contribute to lipid translocation across the li-pid bilayers on the cellular membranes. In this review, we will highlight current knowledge about the role of cholesterol and phospholipids of cellular membrane in regulating cell signaling and how lipid transporters participate this process.

P4-ATPase; ABC transporter; phospholipid; cholesterol; membranes; cellular signaling

Biology and Life Sciences, Biochemistry and Molecular Biology

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Transporters Beam Signals from Cell Membranes

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