Hypothesis
Version 1
Preserved in Portico This version is not peer-reviewed
Pathological T Helper Polarization Requires Pre-existing Cross-Reactive Memory T Cells
Version 1
: Received: 11 August 2021 / Approved: 12 August 2021 / Online: 12 August 2021 (08:46:55 CEST)
How to cite: Usharauli, D.; Kamala, T. Pathological T Helper Polarization Requires Pre-existing Cross-Reactive Memory T Cells. Preprints 2021, 2021080270. https://doi.org/10.20944/preprints202108.0270.v1 Usharauli, D.; Kamala, T. Pathological T Helper Polarization Requires Pre-existing Cross-Reactive Memory T Cells. Preprints 2021, 2021080270. https://doi.org/10.20944/preprints202108.0270.v1
Abstract
Naive CD4+ T cells engage cognate peptide MHC-II complexes (pMHC-IIs) to differentiate and acquire one of several T helper (Th) fates whose specific trajectories are guided by a dynamic cytokine milieu that develops in response to antigenic entity. This physiological process is often erroneously conflated with a pathological one termed Th polarization. Using the SPIRAL model, we argue here that unlike Th fate choice, innate signaling alone is insufficient to initiate Th polarization in naive CD4+ T cells, that it instead develops from pre-existing memory CD4+ T cells that express cross-reactive TCRs, and that it inevitably leads to immunopathology.
Keywords
T helper differentiation; T helper polarization; Cross-reactivity; Regulatory T cells; Microbiota; Original Antigenic Sin
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment