Review
Version 1
Preserved in Portico This version is not peer-reviewed
Telomere Targeting Approaches in Cancer: Over the Length Maintenance.
Version 1
: Received: 18 November 2021 / Approved: 19 November 2021 / Online: 19 November 2021 (14:56:06 CET)
How to cite: Vertecchi, E.; Rizzo, A.; Salvati, E. Telomere Targeting Approaches in Cancer: Over the Length Maintenance.. Preprints 2021, 2021110367. https://doi.org/10.20944/preprints202111.0367.v1 Vertecchi, E.; Rizzo, A.; Salvati, E. Telomere Targeting Approaches in Cancer: Over the Length Maintenance.. Preprints 2021, 2021110367. https://doi.org/10.20944/preprints202111.0367.v1
Abstract
Telomeres are crucial structures that preserve genome stability. Their progressive erosion over rounds of DNA duplication determines senescence of cells and organisms. Telomere length homeostasis is critical for cancer development then telomere maintenance mechanisms are established targets in cancer treatment. Besides telomere elongation, telomere’s dysfunction impinges on intracellular signalling pathways, in particular DNA damage signalling and repair affecting cancer cell survival and proliferation. This review summarizes and discusses about the recent findings in anti-cancer drug development targeting different “telosome” components.
Keywords
telomeres; shelterins; cancer; G-quadruplex ligands
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment