Article
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Integrated Analysis of the miRNA-mRNA Regulatory Network Involved in the HIV-Associated Neurocognitive Disorder
Version 1
: Received: 18 February 2022 / Approved: 23 February 2022 / Online: 23 February 2022 (14:13:59 CET)
A peer-reviewed article of this Preprint also exists.
Liu, C.; Ding, Q.; Kong, X. Integrated Analysis of the miRNA-mRNA Regulatory Network Involved in HIV-Associated Neurocognitive Disorder. Pathogens 2022, 11, 407. Liu, C.; Ding, Q.; Kong, X. Integrated Analysis of the miRNA-mRNA Regulatory Network Involved in HIV-Associated Neurocognitive Disorder. Pathogens 2022, 11, 407.
Abstract
HIV-associated neurocognitive disorder (HAND) is an array of neurocognitive changes associated with HIV infection, and the roles of microRNAs in HAND are not completely revealed yet. Based on published data and publicly available databases, we constructed an integrated miRNA-mRNA network involved in HAND. Bioinformatics analyses, including gene ontology, network analysis, and KEGG pathway analysis, were applied for further study of the network and the genes of the network. The axon guidance KEGG pathway, three genes NTNG1, EFNB2, CXCL12, and 17 miRNAs which regulates them, are spotlighted in our study. This study provides new perspectives to the knowledge of miRNAs’ roles in the process of HAND, and our findings provided potential therapeutic targets and clues of HAND.
Keywords
miRNA; mRNA; HIV; network; bioinformatics; HAND; viral infection; CNS damage
Subject
Biology and Life Sciences, Virology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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