Review
Version 1
Preserved in Portico This version is not peer-reviewed
Adverse Renal Effects of Anticancer Immunotherapy: A Review
Version 1
: Received: 15 July 2022 / Approved: 18 July 2022 / Online: 18 July 2022 (09:21:56 CEST)
A peer-reviewed article of this Preprint also exists.
Borówka, M.; Łącki-Zynzeling, S.; Nicze, M.; Kozak, S.; Chudek, J. Adverse Renal Effects of Anticancer Immunotherapy: A Review. Cancers 2022, 14, 4086. Borówka, M.; Łącki-Zynzeling, S.; Nicze, M.; Kozak, S.; Chudek, J. Adverse Renal Effects of Anticancer Immunotherapy: A Review. Cancers 2022, 14, 4086.
Abstract
Modern oncological therapy utilizes various types of immunotherapy. Immune checkpoint inhib-itors (ICIs), chimeric antigen receptor T cells (CAR-T) therapy, cancer vaccines and bispecific an-tibodies are improving patients’ outcomes. However, stimulation of the immune system, benefi-cial in terms of fighting against cancer, generates the risk of harm to other cells in a patient's body. Kidney damage belongs to the relatively rare adverse events (AEs). Best described, but still, su-perficially, are renal AEs in patients treated with ICIs. International guidelines issued by Euro-pean Society for Medical Oncology (ESMO) and American Society of Clinical Oncology (ASCO) cover the management of immune-related adverse events (irAEs) during ICI therapy. There are scarce data concerning renal adverse drug reactions of other immunotherapeutic methods. This implicates the need for the collection of safety data during ongoing clinical trials and in the re-al-life world to characterize the hazard related to the use of new immunotherapies and manage-ment of irAEs.
Keywords
cancer; immunotherapy; adverse events; immune checkpoints inhibitors; chimeric antigen receptor therapy; bispecific antibodies; toxicity; renal; oncology
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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