Review
Version 1
Preserved in Portico This version is not peer-reviewed
The Function of Histone Modifications in Chronic Obstructive Pulmonary Disease
Version 1
: Received: 12 August 2022 / Approved: 15 August 2022 / Online: 15 August 2022 (15:10:21 CEST)
How to cite: Foroughi Nezhad, A. The Function of Histone Modifications in Chronic Obstructive Pulmonary Disease. Preprints 2022, 2022080265. https://doi.org/10.20944/preprints202208.0265.v1 Foroughi Nezhad, A. The Function of Histone Modifications in Chronic Obstructive Pulmonary Disease. Preprints 2022, 2022080265. https://doi.org/10.20944/preprints202208.0265.v1
Abstract
Numerous genes expression lead to inflammation in the individuals’ lungs that have chronic obstructive pulmonary disease (COPD) may be affected by epigenetic alteration. Important epigenetic processes include methylation of DNA and different histones post-translational changes, including ubiquitination, phosphorylation, methylation, SUMOylation and acetylation. Smoking can trigger the enzymes that control these epigenetic changes. According to the majority of publications, both environmental and genetic variables have a substantial role in the development of COPD. Although, the information about COPD epigenetic is not much but, a better perception of the disease pathophysiology and identifying new markers to create novel therapeutics for patients can be achieved via a better understanding of the epigenetic processes involved.
Keywords
Post-translational modifications; Epigenetics; Histone Phosphorylation; Histone Ubiquitination; Histone methylation; inflammation; proinflammatory cytokines; DNA methylation; COPD
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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