Review
Version 1
Preserved in Portico This version is not peer-reviewed
A Mini Review of Novel Topoisomerase II Inhibitors as Future Anticancer Agents
Version 1
: Received: 2 November 2022 / Approved: 8 November 2022 / Online: 8 November 2022 (06:22:07 CET)
A peer-reviewed article of this Preprint also exists.
Okoro, C.O.; Fatoki, T.H. A Mini Review of Novel Topoisomerase II Inhibitors as Future Anticancer Agents. Int. J. Mol. Sci. 2023, 24, 2532. Okoro, C.O.; Fatoki, T.H. A Mini Review of Novel Topoisomerase II Inhibitors as Future Anticancer Agents. Int. J. Mol. Sci. 2023, 24, 2532.
Abstract
Several reviews of inhibitors of topoisomerase II literature have been published covering research before 2018. Therefore, this review is focused primarily on more recent publications with relevant points from the earlier literature. Topoisomerase II is an established target for anticancer drugs, that are further subdivided into poisons and catalytic inhibitors. Whereas most of the topoisomerase II-based drugs in clinical use are mostly topoisomerase II poisons, their mechanism of action has posed severe concern due to DNA damaging potential, including development of multi drug resistance. As a result, we are beginning to see a gradual paradigm shift towards a non-DNA damaging agents, such as the lesser studied topoisomerase II catalytic inhibitors. In addition, this review will describe some novel selective catalytic topoisomerase II inhibitors. The ultimate goal is to bring researchers up to speed by curating and delineating new scaffolds as leads for optimization and development to new potent, safe and selective agents for the treatment of cancer.
Keywords
topoisomerase; anticancer; cancer; anticancer drugs; enzyme
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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