Article
Version 1
Preserved in Portico This version is not peer-reviewed
Obstructive Sleep Apnea as a Cause of Gout
Version 1
: Received: 22 February 2023 / Approved: 24 February 2023 / Online: 24 February 2023 (09:31:14 CET)
How to cite: Abrams, B.; Delannoy, P.; Johnson, R. Obstructive Sleep Apnea as a Cause of Gout. Preprints 2023, 2023020425. https://doi.org/10.20944/preprints202302.0425.v1 Abrams, B.; Delannoy, P.; Johnson, R. Obstructive Sleep Apnea as a Cause of Gout. Preprints 2023, 2023020425. https://doi.org/10.20944/preprints202302.0425.v1
Abstract
Gout is not only associated with obstructive sleep apnea (OSA), but the intermittent episodes of hypoxia that occur with OSA may also have a role in causing gout. Epidemiological studies have documented a higher incidence and prevalence of gout in individuals diagnosed with OSA than in individuals never diagnosed with OSA. The pathophysiology of OSA’s chronic episodes of hypoxia leading to hyperuricemia and gout involves boththe overproduction and underexcretion of uric acid. Treating OSA may be an additional way to control gout and its life-threatening comorbidities. Clinicians are urged to evaluate their patients with hyperuricemia/gout for OSA as it may lead to alternative ways to control gout with superior outcomes that simply pharmacologic treatment alone.
Keywords
sleep apnea; hypoxia; gout; hyperuricemia; urate; metabolic comorbidities
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Commenter: Richard J Johnson MD
The commenter has declared there is no conflict of interests.