Article
Version 1
Preserved in Portico This version is not peer-reviewed
The Case For Including Neuroprotective Factors in Sporadic Creutzfeldt-Jakob Questionnaires
Version 1
: Received: 19 February 2023 / Approved: 27 February 2023 / Online: 27 February 2023 (08:42:14 CET)
How to cite: Reed, R. The Case For Including Neuroprotective Factors in Sporadic Creutzfeldt-Jakob Questionnaires. Preprints 2023, 2023020461. https://doi.org/10.20944/preprints202302.0461.v1 Reed, R. The Case For Including Neuroprotective Factors in Sporadic Creutzfeldt-Jakob Questionnaires. Preprints 2023, 2023020461. https://doi.org/10.20944/preprints202302.0461.v1
Abstract
Background: Demonstrate a theoretical and empirical justification for including potentially protective factors in Sporadic Creutzfeldt-Jakob case-controlled studies alongside the almost exclusively studied risk-enhancing factors. Methods: Synthesize existing sCJD and Alzheimer's disease (AD) research to suggest the plausibility of shared neuroprotective factors. A fixed effects longitudinal analysis of 26 countries across 10 time periods examines whether factors identified to protect against AD are associated with population-level sCJD incidence rates. Results: Increased consumption of beans and nuts, both of which are thought to protect against AD risk, is associated with lower population level sCJD incidence. Conclusion: This study suggests that factors that protect against other neurodegenerative diseases might offer protection from sCJD. The low marginal burden of including protective factors in sCJD questionnaires offers a chance to better understand sCJD at little additional cost.
Keywords
Prion Disease; Creutzfeldt-Jakob; Diet; Dementia
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment