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A Glimpse into Chromatin Organization and Nuclear Lamina Contribution in Neuronal Differentiation
Version 1
: Received: 22 April 2023 / Approved: 23 April 2023 / Online: 23 April 2023 (08:09:57 CEST)
A peer-reviewed article of this Preprint also exists.
Martino, S.; Carollo, P.S.; Barra, V. A Glimpse into Chromatin Organization and Nuclear Lamina Contribution in Neuronal Differentiation. Genes 2023, 14, 1046. Martino, S.; Carollo, P.S.; Barra, V. A Glimpse into Chromatin Organization and Nuclear Lamina Contribution in Neuronal Differentiation. Genes 2023, 14, 1046.
Abstract
During embryonic development stem cells undergo the differentiation process so that they can specialise for different functions within the organism. Complex programs of gene transcription are crucial for this process to happen. Epigenetic modifications and the architecture of chromatin in the nucleus, by the formation of specific regions of active as well as inactive chromatin, allow the coordinated regulation of the genes for each cell fate. In this mini review, we discuss the current knowledge regarding the regulation of three-dimensional chromatin structure during neuronal differentiation. We also focus on the role played in neurogenesis by the nuclear lamina that ensures the tethering of the chromatin to the nuclear envelope.
Keywords
chromatin organization; nuclear lamina; epigenetics; neuronal differentiation
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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