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New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle
Version 1
: Received: 23 May 2023 / Approved: 24 May 2023 / Online: 24 May 2023 (05:00:56 CEST)
A peer-reviewed article of this Preprint also exists.
Yu, J.-D.; Yu, D.-D.; Su, M.-Z.; Gu, Y.-C.; Wang, H.; Guo, Y.-W. New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle. Mar. Drugs 2023, 21, 362. Yu, J.-D.; Yu, D.-D.; Su, M.-Z.; Gu, Y.-C.; Wang, H.; Guo, Y.-W. New Antibacterial Diterpenoids from the South China Sea Soft Coral Klyxum molle. Mar. Drugs 2023, 21, 362.
Abstract
Fifteen new diterpenoids, namely xishaklyanes A-O (1-15), along with three known related ones (16-18), were isolated from the soft coral Klyxum molle collected from Xisha Islands, South China Sea. The stereochemistry of the new compounds were elucidated by a combination of detailed spectroscopic analyses, chemical syntheses, quantum chemical calculations and comparison with the reported data. The absolute configuration of compound 18 was established by the modified Mosher's method for the first time. In bioassay, some of these compounds exhibited considerable antibacterial activities on fish pathogenic bacteria, and compound 4 showed the most effective activity with MIC of 0.225 g/mL against Lactococcus garvieae.
Keywords
Soft coral; Klyxum molle; Diterpenoids; Stereochemistry; Antibacterial activity
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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