Review
Version 1
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The Interplay between Histone Modifiers and p53 in Regulating Gene Expression
Version 1
: Received: 29 May 2023 / Approved: 30 May 2023 / Online: 30 May 2023 (11:14:08 CEST)
A peer-reviewed article of this Preprint also exists.
Kim, H.-M.; Zheng, X.; Lee, E. Experimental Insights into the Interplay between Histone Modifiers and p53 in Regulating Gene Expression. Int. J. Mol. Sci. 2023, 24, 11032. Kim, H.-M.; Zheng, X.; Lee, E. Experimental Insights into the Interplay between Histone Modifiers and p53 in Regulating Gene Expression. Int. J. Mol. Sci. 2023, 24, 11032.
Abstract
Chromatin structure plays a fundamental role in regulating gene expression, with histone modifiers shaping the structure of chromatin by adding or removing chemical changes to his-tone proteins. The p53 transcription factor controls gene expression, binds target genes, and regulates their activity. While p53 has been extensively investigated in the context of cancer research, its association with histone modifiers has received limited attention. This review ex-plores the interplay between histone modifiers and p53 in regulating gene expression. We discussed how histone modifications can influence how p53 binds to target genes and how this interplay can be disrupted in cancer cells. This study provides insights into the complex mechanisms underlying gene regulation and their implications for potential cancer therapy.
Keywords
Histone modifications; p53; cancer; gene regulation; chromatin structure
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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