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Microglial Activation: Key Players in SepsisAssociated Encephalopathy
Version 1
: Received: 22 August 2023 / Approved: 22 August 2023 / Online: 22 August 2023 (12:09:47 CEST)
A peer-reviewed article of this Preprint also exists.
Hu, J.; Xie, S.; Zhang, H.; Wang, X.; Meng, B.; Zhang, L. Microglial Activation: Key Players in Sepsis-Associated Encephalopathy. Brain Sci. 2023, 13, 1453. Hu, J.; Xie, S.; Zhang, H.; Wang, X.; Meng, B.; Zhang, L. Microglial Activation: Key Players in Sepsis-Associated Encephalopathy. Brain Sci. 2023, 13, 1453.
Abstract
Sepsis-associated encephalopathy (SAE) is a common brain dysfunction following sepsis that often results in severe cognitive and neurological sequelae and increases the mortality rate in patients with sepsis. Microglia are resident macrophages in the brain that play essential roles in the pathological and physiological processes of SAE. Depending on the nature of the stimulus, microglia can adopt two polarization states (M1/M2), which correspond to altered microglial morphology, gene expression, and function. Therefore, we systematically described the pathogenesis, morphology, function, and phenotype of microglial activation in SAE. We demonstrated that microglia are closely related to occurrence and development of SAE and concomitant cognitive impairement. Finally, we outlined some potential therapeutic approaches that can prime microglia and neuroinflammation towards the beneficial restorative microglial phenotype in SAE.
Keywords
Sepsis-associated encephalopathy; Microglial activation; M1/M2 microglial polarization; cognitive impairment; therapeutic strategies
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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