PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Comparative Analysis of Frailty Identification Criteria on Continuous Non-invasive Neurocardiovascular Signals during an Active Stand Test in the Irish Longitudinal Study on Ageing (TILDA)
Version 1
: Received: 11 November 2023 / Approved: 13 November 2023 / Online: 13 November 2023 (10:50:07 CET)
How to cite:
Xue, F.; Knight, S. P.; Connolly, E.; O’Halloran, A. M.; Shirsath, M. A.; Newman, L.; Duggan, E.; Kenny, R. A.; Romero-Ortuno, R. Comparative Analysis of Frailty Identification Criteria on Continuous Non-invasive Neurocardiovascular Signals during an Active Stand Test in the Irish Longitudinal Study on Ageing (TILDA). Preprints2023, 2023110744. https://doi.org/10.20944/preprints202311.0744.v1
Xue, F.; Knight, S. P.; Connolly, E.; O’Halloran, A. M.; Shirsath, M. A.; Newman, L.; Duggan, E.; Kenny, R. A.; Romero-Ortuno, R. Comparative Analysis of Frailty Identification Criteria on Continuous Non-invasive Neurocardiovascular Signals during an Active Stand Test in the Irish Longitudinal Study on Ageing (TILDA). Preprints 2023, 2023110744. https://doi.org/10.20944/preprints202311.0744.v1
Xue, F.; Knight, S. P.; Connolly, E.; O’Halloran, A. M.; Shirsath, M. A.; Newman, L.; Duggan, E.; Kenny, R. A.; Romero-Ortuno, R. Comparative Analysis of Frailty Identification Criteria on Continuous Non-invasive Neurocardiovascular Signals during an Active Stand Test in the Irish Longitudinal Study on Ageing (TILDA). Preprints2023, 2023110744. https://doi.org/10.20944/preprints202311.0744.v1
APA Style
Xue, F., Knight, S. P., Connolly, E., O’Halloran, A. M., Shirsath, M. A., Newman, L., Duggan, E., Kenny, R. A., & Romero-Ortuno, R. (2023). Comparative Analysis of Frailty Identification Criteria on Continuous Non-invasive Neurocardiovascular Signals during an Active Stand Test in the Irish Longitudinal Study on Ageing (TILDA). Preprints. https://doi.org/10.20944/preprints202311.0744.v1
Chicago/Turabian Style
Xue, F., Rose Anne Kenny and Roman Romero-Ortuno. 2023 "Comparative Analysis of Frailty Identification Criteria on Continuous Non-invasive Neurocardiovascular Signals during an Active Stand Test in the Irish Longitudinal Study on Ageing (TILDA)" Preprints. https://doi.org/10.20944/preprints202311.0744.v1
Abstract
In this observational study, we compared continuous physiological signals during an active stand test in adults aged 50 years and over, characterized as frail by three different criteria, using data from The Irish Longitudinal Study on Ageing (TILDA). Four independent groups were identified: those characterized as frail only by one of the frailty tools used (the physical Frailty Phenotype (FP), the 32-item Frailty Index (FI), or the Clinical Frailty Scale (CFS) classification tree), and a fourth group where participants were not characterized as frail by any of these tools. Continuous non-invasive physiological signals were collected during an active stand test: systolic (sBP) and diastolic (dBP) blood pressure, as well as heart rate (HR), using digital artery photoplethysmography. Additionally, frontal lobe cerebral oxygenation (Oxy), deoxygenation (Deoxy), and tissue saturation index (TSI) were also non-invasively measured using near-infrared spectroscopy (NIRS). The signals were visualized across frailty groups and statistically compared using one-dimensional statistical parametric mapping (SPM). A total of 1,124 participants (mean age 63.5 years, 50.2% women) were included: 23 were characterized as frail only by FP, 97 by FI, 38 by CFS, and 966 by none of these criteria. SPM analyses revealed that only the group characterized as frail by FI had significantly different signals (p<0.05) compared to the non-frail group. Specifically, they exhibited a lesser increase in HR between 5-15 seconds post-stand and larger deficits in sBP and dBP between 15-40 seconds post-stand, and possibly a lower Delta TSI at 20 seconds post-stand. In this comparison, the FI proved more adept at capturing distinct physiological responses to standing, likely due to its direct inclusion of cardiovascular morbidities in its definition.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
,
