Wang, C.; Yao, S.; Zhang, T.; Sun, X.; Bai, C.; Zhou, P. RNA N6-Methyladenosine Modification in DNA Damage Response and Cancer Radiotherapy. Int. J. Mol. Sci.2024, 25, 2597.
Wang, C.; Yao, S.; Zhang, T.; Sun, X.; Bai, C.; Zhou, P. RNA N6-Methyladenosine Modification in DNA Damage Response and Cancer Radiotherapy. Int. J. Mol. Sci. 2024, 25, 2597.
Wang, C.; Yao, S.; Zhang, T.; Sun, X.; Bai, C.; Zhou, P. RNA N6-Methyladenosine Modification in DNA Damage Response and Cancer Radiotherapy. Int. J. Mol. Sci.2024, 25, 2597.
Wang, C.; Yao, S.; Zhang, T.; Sun, X.; Bai, C.; Zhou, P. RNA N6-Methyladenosine Modification in DNA Damage Response and Cancer Radiotherapy. Int. J. Mol. Sci. 2024, 25, 2597.
Abstract
N6-methyladenosine (M6A) modification is the most abundant internal chemical modification on RNA molecules in eukaryotes and can affect mRNA metabolism and regulate RNA transcription, nuclear export, splicing, degradation, translation, ets, and has a significant impact on various aspects of physiology or pathobiology. Radiotherapy is the most common measure of tumor treatment, variety of cellular intrinsic mechanisms affect the responses of cells to ionizing radiation (IR) and effectiveness of cancer radiotherapy. In this review, we summarize and discuss the recent advances about the roles and mechanisms of RNA M6A methylation in cellular responses to radiation-induced DNA damage response, and outcomes of cancer radiotherapy. Insights into the RNA M6A methylation in radiation biology may facilitate the improvement of therapeutic strategies for cancer radiotherapy as well as radioprotection on normal tissues.
Keywords
M6A modification; DNA damage response; radioresistance; cancer radiotherapy
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
