Review
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Preserved in Portico This version is not peer-reviewed
Extraribosomal Functions of Bacterial Ribosomal Proteins—an Update 2023
Version 1
: Received: 25 January 2024 / Approved: 26 January 2024 / Online: 26 January 2024 (08:33:52 CET)
A peer-reviewed article of this Preprint also exists.
Aseev, L.V.; Koledinskaya, L.S.; Boni, I.V. Extraribosomal Functions of Bacterial Ribosomal Proteins—An Update, 2023. Int. J. Mol. Sci. 2024, 25, 2957. Aseev, L.V.; Koledinskaya, L.S.; Boni, I.V. Extraribosomal Functions of Bacterial Ribosomal Proteins—An Update, 2023. Int. J. Mol. Sci. 2024, 25, 2957.
Abstract
Ribosomal proteins (r-proteins) are abundant, highly conserved, and multifaceted cellular proteins in all domains of life. Most r-proteins have RNA-binding properties and are able to form protein-protein contacts. Bacterial r-proteins govern the co-transcriptional rRNA folding during ribosome assembly and participate in formation of the ribosome functional sites such as the mRNA binding site, tRNA binding sites, the peptidyl- transferase center, and the protein exit tunnel. In addition to their primary role in a cell as integral components of the protein synthesis machinery, many of r-proteins can function beyond the ribosome (the phenomenon known as moonlighting), acting either as individual regulatory proteins or in complexes with various cellular components. Extraribosomal activities of r-proteins have been intensively studied over decades (reviewed in [1]). The past decade brought significant advancement in our knowledge of r-protein functions due to expanding studies on ribosomes and gene expression mechanisms not only in model bacteria like Escherichia coli or Bacillus subtilis, but also in previously little-explored bacterial species from various phyla. This review is aimed to update the information on multiple functions of r-proteins in bacteria.
Keywords
bacterial ribosomal proteins; extraribosomal functions; RNA-protein interactions; protein-protein interactions; regulation of gene expression
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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