Review
Version 1
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Intravenous Lipid Emulsions in Anticonvulsants' Toxicity
Version 1
: Received: 24 April 2024 / Approved: 25 April 2024 / Online: 25 April 2024 (16:52:46 CEST)
How to cite: Dimitrova, S. D.; Dragomanova, S. T.; Kehayova, G. K. Intravenous Lipid Emulsions in Anticonvulsants' Toxicity. Preprints 2024, 2024041698. https://doi.org/10.20944/preprints202404.1698.v1 Dimitrova, S. D.; Dragomanova, S. T.; Kehayova, G. K. Intravenous Lipid Emulsions in Anticonvulsants' Toxicity. Preprints 2024, 2024041698. https://doi.org/10.20944/preprints202404.1698.v1
Abstract
(1) Background: In recent years, an innovative approach has emerged in the field of toxicology for managing acute intoxications caused by lipophilic substances: intravenous lipid emulsions (ILE). Through numerous experiments and case reports, the efficacy of lipid emulsions in counteracting toxicities induced by lipophilic agents, including a significant number of antiepileptic drugs (AE), has become increasingly evident. (2) Methods: Data spanning a 10-year period (2010-2020) was analyzed by searching through multiple scientific publication platforms like PubMed, Science Direct, Research Gate, and Springer Link. The study focused on reviewing relevant case reports detailing successful Intravenous lipid emulsion (ILE) administration in pa-tients with acute intoxications with antiepileptics, specifically examining the impact of fat emul-sions on neurological status, Glasgow Coma Scale (GCS) scores, and corrected QT interval con-cerning hemodynamic instability. (3) Results: The typical symptoms of antiepileptic toxicity in-clude central nervous system depression, ataxia, and nystagmus. Intravenous lipid emulsion ap-plication resulted in an increase in Glasgow Coma Scale scores and enhanced recovery from drug intoxication. (4) Conclusions: This study provides a comprehensive overview of the potential utility of ILE as a component to antidote therapy in cases of acute AE poisoning involving neurotropic drugs. The process involves the engagement of various mechanisms of antitoxic activity.
Keywords
intravenous lipid emulsion; acute intoxication; antiepileptics; antidote; Glasgow Coma Scale scores; QT interval
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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