Anderlini, B.; Severini, A.; Ferrari, C.; Fontanesi, C.; Ascari, V.; Braidi, N.; Roncaglia, F. Atom Exchange Radical Cyclization: A Sustainable Synthetic Approach towards New Functionalized Targets. Appl. Sci.2024, 14, 4357.
Anderlini, B.; Severini, A.; Ferrari, C.; Fontanesi, C.; Ascari, V.; Braidi, N.; Roncaglia, F. Atom Exchange Radical Cyclization: A Sustainable Synthetic Approach towards New Functionalized Targets. Appl. Sci. 2024, 14, 4357.
Anderlini, B.; Severini, A.; Ferrari, C.; Fontanesi, C.; Ascari, V.; Braidi, N.; Roncaglia, F. Atom Exchange Radical Cyclization: A Sustainable Synthetic Approach towards New Functionalized Targets. Appl. Sci.2024, 14, 4357.
Anderlini, B.; Severini, A.; Ferrari, C.; Fontanesi, C.; Ascari, V.; Braidi, N.; Roncaglia, F. Atom Exchange Radical Cyclization: A Sustainable Synthetic Approach towards New Functionalized Targets. Appl. Sci. 2024, 14, 4357.
Abstract
In this study, we demonstrate the direct preparation of dihalo-γ-lactams featuring two distinct halogens from dichloroamides using a novel Atom Exchange Radical Cyclization (AERC) procedure. This method integrates the established Atom Transfer Radical Cyclization with halogen exchange in solution. The technique operates under mild conditions and requires little amounts of metallic copper, serving as both a supplemental activator and reducing agent.
Keywords
atom transfer radical cyclization; transition metal catalysis; γ-lactams; halocompounds
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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