Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Intralesional Vessel Diameter Measured by Optical Coherence Tomography Angiography Could Improve the Differential Diagnosis of Small Melanocytic Choroidal Lesions

Laura Vigués-Jorba
* ,
Daniel Lorenzo
ORCID logo ,
Cristina Pujadas
,
Rahul Morwani
,
Liria Yamamoto-Rodriguez
,
Maria Baradad-Jurjo
,
Lluis Arias
,
Estefanía Cobos
,
Pere Garcia-Bru
,
Juan-Francisco Santamaría
,
Olga Garcia Garcia
,
Josep Maria Caminal
Version 1 : Received: 6 May 2024 / Approved: 6 May 2024 / Online: 6 May 2024 (09:35:17 CEST)

How to cite: Vigués-Jorba, L.; Lorenzo, D.; Pujadas, C.; Morwani, R.; Yamamoto-Rodriguez, L.; Baradad-Jurjo, M.; Arias, L.; Cobos, E.; Garcia-Bru, P.; Santamaría, J.-F.; Garcia Garcia, O.; Caminal, J. M. Intralesional Vessel Diameter Measured by Optical Coherence Tomography Angiography Could Improve the Differential Diagnosis of Small Melanocytic Choroidal Lesions. Preprints 2024, 2024050278. https://doi.org/10.20944/preprints202405.0278.v1 Vigués-Jorba, L.; Lorenzo, D.; Pujadas, C.; Morwani, R.; Yamamoto-Rodriguez, L.; Baradad-Jurjo, M.; Arias, L.; Cobos, E.; Garcia-Bru, P.; Santamaría, J.-F.; Garcia Garcia, O.; Caminal, J. M. Intralesional Vessel Diameter Measured by Optical Coherence Tomography Angiography Could Improve the Differential Diagnosis of Small Melanocytic Choroidal Lesions. Preprints 2024, 2024050278. https://doi.org/10.20944/preprints202405.0278.v1

Abstract

In this study, we aimed to identify the features of indeterminate choroidal melanocytic lesions visualized on optical coherence tomography angiography (OCTA) and to identify predictors of growth. We retrospectively evaluated 86 patients with indeterminate lesions treated at our cen-tre from 2016 to 2021. Clinical management involved active surveillance followed by brachy-therapy if growth was detected. The lesions were classified into two groups according to wheth-er they grew (small melanomas) or remained stable (choroidal nevi). Growth was detected in 19 (22.1%) lesions. All patients underwent OCTA at baseline. These images were compared to iden-tify possible predictors of growth. Significant between-group differences were observed in thickness (p=0.00), greatest basal diameter (p=0.00), number of risk factors (p=0.00), symptoms (p=0.001; relative risk [RR]: 4.3), orange pigment (p=0.00; RR: 6.02), and ultrasonographic hol-lowness (Kappa sign); p=0.000; RR: 5.3). The melanomas had significantly more vessels with a diameter ≥ 76.3 µm (p=0.02; RR: 2.46). The time to growth in these lesions was significantly shorter (p=0.05) than in lesions with smaller vessels. These findings show that vessel diameter quantified by OCTA can differentiate between choroidal nevi and small melanomas, especially when considered together with clinical risk factors.

Keywords

choroidal melanoma; choroidal nevus; optical coherence tomography angiography; OCTA

Subject

Medicine and Pharmacology, Ophthalmology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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