Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

IGF-1 and IGFBP-1, Possible Predictors of Response to Lifestyle Intervention – Results from Randomized Controlled Trials

Nina M.T. Meyer
,
Stefan Kabisch
ORCID logo ,
Ulrike Dambeck
,
Caroline Honsek
,
Margrit Kemper
,
Christiana Gerbracht
,
Ayman M. Arafat
,
Andreas L. Birkenfeld
,
Peter E. H. Schwarz
ORCID logo ,
Jürgen Machann
,
Martin A. Osterhoff
,
Martin O. Weickert
ORCID logo ,
Andreas F. H. Pfeiffer
*
Version 1 : Received: 8 May 2024 / Approved: 8 May 2024 / Online: 8 May 2024 (12:45:40 CEST)

How to cite: Meyer, N. M.; Kabisch, S.; Dambeck, U.; Honsek, C.; Kemper, M.; Gerbracht, C.; Arafat, A. M.; Birkenfeld, A. L.; Schwarz, P. E. H.; Machann, J.; Osterhoff, M. A.; Weickert, M. O.; Pfeiffer, A. F. H. IGF-1 and IGFBP-1, Possible Predictors of Response to Lifestyle Intervention – Results from Randomized Controlled Trials. Preprints 2024, 2024050501. https://doi.org/10.20944/preprints202405.0501.v1 Meyer, N. M.; Kabisch, S.; Dambeck, U.; Honsek, C.; Kemper, M.; Gerbracht, C.; Arafat, A. M.; Birkenfeld, A. L.; Schwarz, P. E. H.; Machann, J.; Osterhoff, M. A.; Weickert, M. O.; Pfeiffer, A. F. H. IGF-1 and IGFBP-1, Possible Predictors of Response to Lifestyle Intervention – Results from Randomized Controlled Trials. Preprints 2024, 2024050501. https://doi.org/10.20944/preprints202405.0501.v1

Abstract

Lifestyle interventions can prevent type 2 diabetes (T2DM). However, some in-dividuals do not experience anticipated improvements despite weight loss. Bi-omarkers to identify such individuals at early stages are lacking. IGF-1 and IGFBP-1 were shown to predict T2DM onset in prediabetes. We assessed if these markers also predict the success of lifestyle interventions, thereby possibly guid-ing personalized strategies. We analyzed fasting serum levels of IGF-1, IGFBP-1 and IGFBP-2 in relation to changes in metabolic and anthropometric parameters, including intrahepatic li-pids (IHL) and visceral adipose tissue (VAT) volume measured by MRI, in 345 high-risk prediabetic participants (54% female; aged 36-80 years). Participants were enrolled in three randomized dietary intervention trials and assessed both at baseline and one year post-intervention. Statistical analyses were performed using IBM SPSS Statistics (version 28), significance set at p

Keywords

IGF-axis; lifestyle intervention; intervention response; prediabetes

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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