PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
The Detection of Vaccine Virus and Protection of a Modified Live, Intranasal, Tri-Valent Vaccine in Neonatal, Colostrum-Fed Calves with an Experimental Bovine Respiratory Syncytial Virus Challenge
Version 1
: Received: 7 May 2024 / Approved: 8 May 2024 / Online: 8 May 2024 (16:09:04 CEST)
How to cite:
Perkins-Oines, S.; Senevirathne, N. D.; Krafsur, G. M.; Abdelsalam, K.; Renter, D. G.; Meyer, B.; Chase, C. C. The Detection of Vaccine Virus and Protection of a Modified Live, Intranasal, Tri-Valent Vaccine in Neonatal, Colostrum-Fed Calves with an Experimental Bovine Respiratory Syncytial Virus Challenge. Preprints2024, 2024050505. https://doi.org/10.20944/preprints202405.0505.v1
Perkins-Oines, S.; Senevirathne, N. D.; Krafsur, G. M.; Abdelsalam, K.; Renter, D. G.; Meyer, B.; Chase, C. C. The Detection of Vaccine Virus and Protection of a Modified Live, Intranasal, Tri-Valent Vaccine in Neonatal, Colostrum-Fed Calves with an Experimental Bovine Respiratory Syncytial Virus Challenge. Preprints 2024, 2024050505. https://doi.org/10.20944/preprints202405.0505.v1
Perkins-Oines, S.; Senevirathne, N. D.; Krafsur, G. M.; Abdelsalam, K.; Renter, D. G.; Meyer, B.; Chase, C. C. The Detection of Vaccine Virus and Protection of a Modified Live, Intranasal, Tri-Valent Vaccine in Neonatal, Colostrum-Fed Calves with an Experimental Bovine Respiratory Syncytial Virus Challenge. Preprints2024, 2024050505. https://doi.org/10.20944/preprints202405.0505.v1
APA Style
Perkins-Oines, S., Senevirathne, N. D., Krafsur, G. M., Abdelsalam, K., Renter, D. G., Meyer, B., & Chase, C. C. (2024). The Detection of Vaccine Virus and Protection of a Modified Live, Intranasal, Tri-Valent Vaccine in Neonatal, Colostrum-Fed Calves with an Experimental Bovine Respiratory Syncytial Virus Challenge. Preprints. https://doi.org/10.20944/preprints202405.0505.v1
Chicago/Turabian Style
Perkins-Oines, S., Brent Meyer and Christopher CL Chase. 2024 "The Detection of Vaccine Virus and Protection of a Modified Live, Intranasal, Tri-Valent Vaccine in Neonatal, Colostrum-Fed Calves with an Experimental Bovine Respiratory Syncytial Virus Challenge" Preprints. https://doi.org/10.20944/preprints202405.0505.v1
Abstract
The efficacy of an intranasal (IN) bovine respiratory syncytial virus (BRSV) administered in the face of passive immunity was assessed. Pooled colostrum was administered by intubation to fifty (50) beef-dairy crossbred calves the day they were born. The calves were transported to a research facility and were blocked by age and sex and randomly assigned into two groups, a sham-vaccinated intranasally with a placebo (sterile water) or vaccinated with a tri-valent modified live viral (MLV) vaccine. The calves were 92 days old when vaccinated (day 0). The calves were challenged by aerosolized BRSV on day 80 and day 81 as a respiratory challenge. The study was terminated on day 88. Lung lesion scores (LLS) were significantly lower for calves vaccinated with tri-valent MLV vaccine than those for calves that were sham-vaccinated. Serum neutralization (SN) antibody against BRSV in calves vaccinated with the tri-valent MLV vaccine demonstrated an anamnestic response on day 88. After challenge, the calves sham-vaccinated with the placebo lost weight while those vaccinated with the tri-valent MLV vaccine gained weight. In this study colostrum-derived antibodies did not interfere with the immune response or protection provided by one dose of the tri-valent MLV vaccine.
Biology and Life Sciences, Animal Science, Veterinary Science and Zoology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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