Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Low Vitamin D Concentration is Associated with Increased Depression Risk in Adults 20-44 Years-Old, an NHANES 2007-2018 Data Analysis with a Focus on Perinatal and Breastfeeding Status

Version 1 : Received: 9 May 2024 / Approved: 10 May 2024 / Online: 10 May 2024 (20:02:58 CEST)

How to cite: Hollinshead, V. R. B. B.; Piaskowski, J. L.; Chen, Y. Low Vitamin D Concentration is Associated with Increased Depression Risk in Adults 20-44 Years-Old, an NHANES 2007-2018 Data Analysis with a Focus on Perinatal and Breastfeeding Status. Preprints 2024, 2024050679. https://doi.org/10.20944/preprints202405.0679.v1 Hollinshead, V. R. B. B.; Piaskowski, J. L.; Chen, Y. Low Vitamin D Concentration is Associated with Increased Depression Risk in Adults 20-44 Years-Old, an NHANES 2007-2018 Data Analysis with a Focus on Perinatal and Breastfeeding Status. Preprints 2024, 2024050679. https://doi.org/10.20944/preprints202405.0679.v1

Abstract

The objective was to investigate associations of serum vitamin D concentration with depressive symptoms and assess the impact vitamin D concentration has on the occurrence of depressive symptoms in 20–44-year-old pregnant mothers, postpartum mothers, women (non-pregnant/postpartum women), and men, including a separate subgroup analysis of postpartum breastfeeding and non-breastfeeding mothers. The study populations were selected from 2007-2018 NHANES public data. Subjective interview data and objective laboratory data, including depressive symptoms, serum vitamin D concentration, nutrient intake, and demographic information were utilized. Two diet patterns were created using principal component analysis and a Bayesian multinomial model was fit to predict depression outcomes for each subpopulation. The estimates for the log vitamin D slope parameter were negative for all cohorts; as vitamin D increased, the probability of having no depression increased, while the probability of depression decreased. The pregnant cohort had the steepest vitamin D slope, followed by postpartum, then other women and men. Higher vitamin D concentration had more impact on decreasing depression risk in pregnant and postpartum mothers compared to other women and men. Among postpartum mothers, higher vitamin D concentration had a greater influence on decreasing breastfeeding mothers' depression risk than non-breastfeeding mothers.

Keywords

25OHD2; 25OHD3; Pregnant; Postpartum; Women; Diet patterns; Mental health; PHQ-9; Depressive symptoms; Human milk

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.