Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Live and Pasteurized Akkermansia muciniphila Mechanisms of Action and Its Potential Use as an Aid in the Treatment of Non-communicable Diseases

Honorata Mruk-Mazurkiewicz
,
Monika Kulaszyńska
ORCID logo ,
Wiktoria Czarnecka
,
Albert Podkówka
,
Natalia Ekstedt
,
Piotr Zawodny
,
Anna Wierzbicka-Woś
,
Wojciech Marlicz
ORCID logo ,
Błażej Skupin
,
Ewa Stachowska
* ORCID logo ,
Igor Łoniewski
,
Karolina Skonieczna-Żydecka
* ORCID logo
Version 1 : Received: 10 May 2024 / Approved: 10 May 2024 / Online: 10 May 2024 (14:22:03 CEST)

How to cite: Mruk-Mazurkiewicz, H.; Kulaszyńska, M.; Czarnecka, W.; Podkówka, A.; Ekstedt, N.; Zawodny, P.; Wierzbicka-Woś, A.; Marlicz, W.; Skupin, B.; Stachowska, E.; Łoniewski, I.; Skonieczna-Żydecka, K. Live and Pasteurized Akkermansia muciniphila Mechanisms of Action and Its Potential Use as an Aid in the Treatment of Non-communicable Diseases. Preprints 2024, 2024050704. https://doi.org/10.20944/preprints202405.0704.v1 Mruk-Mazurkiewicz, H.; Kulaszyńska, M.; Czarnecka, W.; Podkówka, A.; Ekstedt, N.; Zawodny, P.; Wierzbicka-Woś, A.; Marlicz, W.; Skupin, B.; Stachowska, E.; Łoniewski, I.; Skonieczna-Żydecka, K. Live and Pasteurized Akkermansia muciniphila Mechanisms of Action and Its Potential Use as an Aid in the Treatment of Non-communicable Diseases. Preprints 2024, 2024050704. https://doi.org/10.20944/preprints202405.0704.v1

Abstract

This comprehensive review delineates the extensive roles of Akkermansia muciniphila in various health domains, spanning from metabolic and inflammatory diseases to neurodegenerative disorders. A. muciniphila, known for its ability to reside in the mucous layer of the intestine, plays a pivotal role in maintaining gut integrity and interacting with host metabolic processes. Its influence extends to modulating immune responses and potentially easing symptoms across several non-communicable diseases, including obesity, diabetes, and inflammatory bowel disease. Recent studies highlight its capacity to interact with the gut-brain axis, suggesting a possible impact on neuropsychiatric conditions. Despite the promising therapeutic potential of A. muciniphila highlighted in animal and preliminary human studies, challenges remain in its practical application due to stability and cultivation issues. However, the development of pasteurized forms and synthetic mediums offers new avenues for its use in clinical settings, as recognized by regulatory bodies like the European Food Safety Authority. This narrative review serves as a crucial resource for understanding the broad implications of A. muciniphila across different health conditions and its potential integration into therapeutic strategies

Keywords

postbiotic; novel food; microbiota

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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