The Industry 4.0 represents new era of production, characterized by a deep integration between digital technologies and physical systems. Cyber physical systems, cyber resilience protection and workers' safety are key elements of this transformation. To ensure the benefits of Industry 4.0 realized in a secure way, it is crucial to focus on workers' safety, cyber resilience protection and human-centric and CPS systems security and privacy. However, to fully realize the potential of Industry 4.0, it is important to address these challenges and ensure that the benefits of digitalization are balanced with the needs of workers and the protection of critical infrastructure. The concept of Industry 5.0 is emerging as the next step in this evolution, emphasizing the importance of sustainability, human-centered design, and a focus on creating a better future for all.