Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Future role of Health Technology Assessment for Genomic Medicine in Oncology: A Canadian Laboratory Perspective

Version 1 : Received: 15 August 2023 / Approved: 16 August 2023 / Online: 17 August 2023 (07:36:43 CEST)

A peer-reviewed article of this Preprint also exists.

Husereau, D.; Bombard, Y.; Stockley, T.; Carter, M.; Davey, S.; Lemaire, D.; Nohr, E.; Park, P.; Spatz, A.; Williams, C.; Pollett, A.; Lo, B.; Yip, S.; El Hallani, S.; Feilotter, H. Future Role of Health Technology Assessment for Genomic Medicine in Oncology: A Canadian Laboratory Perspective. Curr. Oncol. 2023, 30, 9660-9669. Husereau, D.; Bombard, Y.; Stockley, T.; Carter, M.; Davey, S.; Lemaire, D.; Nohr, E.; Park, P.; Spatz, A.; Williams, C.; Pollett, A.; Lo, B.; Yip, S.; El Hallani, S.; Feilotter, H. Future Role of Health Technology Assessment for Genomic Medicine in Oncology: A Canadian Laboratory Perspective. Curr. Oncol. 2023, 30, 9660-9669.

Abstract

Genome-based testing in oncology is a rapidly expanding area of health care which is the basis of the emerging area of precision medicine. Efficient and considered adoption of novel genomic medicine testing is hampered in Canada by the fragmented nature of health care oversight as well as by lack of clear and transparent processes to support rapid evaluation, assessment and implementation of genomic tests. This article provides an overview of some key barriers and proposes approaches to addressing these challenges as a potential pathway to developing a national approach to genomic medicine in oncology.

Keywords

genomic biomarkers; clinical utility; clinical validity; analytic validity; health technology assessment)

Subject

Public Health and Healthcare, Health Policy and Services

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