Svyatchenko, V.A.; Legostaev, S.S.; Lutkovskiy, R.Y.; Protopopova, E.V.; Ponomareva, E.P.; Omigov, V.V.; Taranov, O.S.; Ternovoi, V.A.; Agafonov, A.P.; Loktev, V.B. Coxsackievirus A7 and Enterovirus A71 Significantly Reduce SARS-CoV-2 Infection in Cell and Animal Models. Viruses2024, 16, 909.
Svyatchenko, V.A.; Legostaev, S.S.; Lutkovskiy, R.Y.; Protopopova, E.V.; Ponomareva, E.P.; Omigov, V.V.; Taranov, O.S.; Ternovoi, V.A.; Agafonov, A.P.; Loktev, V.B. Coxsackievirus A7 and Enterovirus A71 Significantly Reduce SARS-CoV-2 Infection in Cell and Animal Models. Viruses 2024, 16, 909.
Svyatchenko, V.A.; Legostaev, S.S.; Lutkovskiy, R.Y.; Protopopova, E.V.; Ponomareva, E.P.; Omigov, V.V.; Taranov, O.S.; Ternovoi, V.A.; Agafonov, A.P.; Loktev, V.B. Coxsackievirus A7 and Enterovirus A71 Significantly Reduce SARS-CoV-2 Infection in Cell and Animal Models. Viruses2024, 16, 909.
Svyatchenko, V.A.; Legostaev, S.S.; Lutkovskiy, R.Y.; Protopopova, E.V.; Ponomareva, E.P.; Omigov, V.V.; Taranov, O.S.; Ternovoi, V.A.; Agafonov, A.P.; Loktev, V.B. Coxsackievirus A7 and Enterovirus A71 Significantly Reduce SARS-CoV-2 Infection in Cell and Animal Models. Viruses 2024, 16, 909.
Abstract
In this study, we investigated the features of co-infection with SARS-CoV-2 and nonpathogenic strain LEV8 of coxsackievirus A7 or enterovirus A71 for Vero E6 cells and Syrian hamsters. The investigation of co-infection with SARS-СoV-2 and LEV-8 or EV-A71 in the cell model was shown that a competitive inhibitory effect for these viruses were especially significant against SARS-CoV-2. Pre-infection with enteroviruses in animals caused more than a 100-fold decrease in the levels of SARS-CoV-2 virus replication in the respiratory tracts and more rapid clearance of the lower respiratory tract from infectious SARS-CoV-2. Co-infection with SARS-CoV-2 and LEV-8 or EV-A71 also reduced the severity of clinical manifestations of the SARS-CoV-2 infection for animals. Additionally, the histological data illustrated that co-infection with nonpathogenic coxsackievirus decreased the level of pathological changes by SARS-CoV-2 in the lungs. Research into the chemokine/cytokine profile demonstrated that the studied enteroviruses efficiently triggered this part of antiviral immune response, which can be associated with significant inhibition of SARS-CoV-2 infection. These results demonstrate that there exists a strong viral interference between the studied nonpathogenic strain of coxsackievirus A7 or enteroviruses A71 and SARS-CoV-2 pathogenic for humans in vitro and in vivo.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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