Review
Version 1
Preserved in Portico This version is not peer-reviewed
Role of GDNF in Spinal Cord Injury Repair
Version 1
: Received: 17 May 2018 / Approved: 17 May 2018 / Online: 17 May 2018 (12:54:50 CEST)
A peer-reviewed article of this Preprint also exists.
Walker, M.J.; Xu, X.-M. History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair. Brain Sci. 2018, 8, 109. Walker, M.J.; Xu, X.-M. History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair. Brain Sci. 2018, 8, 109.
Abstract
Following an initial mechanical insult, traumatic spinal cord injury (SCI) induces a secondary wave of injury, resulting in a toxic lesion environment inhibitory to axonal regeneration. This review focuses on the glial cell line-derived neurotrophic factor (GDNF) and its application, also in combination with other factors and cell transplantations, for repairing the injured spinal cord. As recent decades of studies strongly suggest combinational treatment approaches hold the greatest therapeutic potential for the central nervous system (CNS) trauma, future directions of combinational therapies will also be discussed.
Keywords
spinal cord injury; glial cell line-derived neurotrophic factor (GDNF), GFRα-1; cRET; Schwann cells; Astrogliosis; neuroprotection; axonal regeneration; combinational therapies; neurotrauma
Subject
Medicine and Pharmacology, Orthopedics and Sports Medicine
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment