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Investigation of Disintegration and Dissolution Behavior of Mefenamic Acid Drug Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata Model on Microtomographic Surfaces and Rational Arrangements of Tablet Components
Yokoyama, R.; Kimura, G.; Schlepütz, C.M.; Huwyler, J.; Puchkov, M. Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces. Pharmaceutics2018, 10, 259.
Yokoyama, R.; Kimura, G.; Schlepütz, C.M.; Huwyler, J.; Puchkov, M. Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces. Pharmaceutics 2018, 10, 259.
Yokoyama, R.; Kimura, G.; Schlepütz, C.M.; Huwyler, J.; Puchkov, M. Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces. Pharmaceutics2018, 10, 259.
Yokoyama, R.; Kimura, G.; Schlepütz, C.M.; Huwyler, J.; Puchkov, M. Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces. Pharmaceutics 2018, 10, 259.
Abstract
There are numerous approaches to model an influence of manufacturing parameters on the dissolution and disintegration of solid dosage forms. A modern approach for modelling and simulating complex and heterogeneous systems such as pharmaceutical tablets focuses on computationally-intensive finite-element or discreet element methods. Industrial challenges such as Process Analytical Technology (PAT) and Quality by Design are stimulating computer-based technologies to design, control and improve the quality of pharmaceutical compacts and their performance. In this study the disintegration and dissolution model based on the numerical solutions of the Noyes-Whitney equation and cellular automata supported disintegration model are proposed and evaluated. The results from in vitro release studies of the mefenamic acid formulations were compared to the calculated release patterns from the tablet structures obtained from microtomography experiments and the purely algorithmically created virtual tablets.
Keywords
drug release simulation; disintegration simulation; poorly water soluble drug; mefenamic acid; Noyes-Whitney equation; cellular automata; synchrotron microtomography
Subject
Computer Science and Mathematics, Computer Vision and Graphics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.