Review
Version 1
Preserved in Portico This version is not peer-reviewed
HDAC6 – An Emerging Target against Chronic Myeloid Leukemia?
Version 1
: Received: 3 January 2020 / Approved: 4 January 2020 / Online: 4 January 2020 (06:18:22 CET)
A peer-reviewed article of this Preprint also exists.
Losson, H.; Schnekenburger, M.; Dicato, M.; Diederich, M. HDAC6—an Emerging Target Against Chronic Myeloid Leukemia? Cancers 2020, 12, 318. Losson, H.; Schnekenburger, M.; Dicato, M.; Diederich, M. HDAC6—an Emerging Target Against Chronic Myeloid Leukemia? Cancers 2020, 12, 318.
Abstract
Imatinib became the standard treatment for chronic myeloid leukemia (CML) about 20 years ago, which was a major breakthrough in stabilizing the pathology and improving the quality of life of patients. However, the emergence of resistance to imatinib and other tyrosine kinase inhibitors leads researchers to characterize new therapeutic targets. Several studies have highlighted the role of histone deacetylase 6 (HDAC6) in various pathologies, including cancer. This protein effectively intervenes in cellular activities by its primarily cytoplasmic localization. In this review, we will discuss the molecular characteristics of the HDAC6 protein, as well as its overexpression in CML leukemic stem cells, which make it a promising therapeutic target for the treatment of CML.
Keywords
histone deacetylase 6 inhibitor; personalized treatment; heat shock protein 90α; leukemia stem cells; imatinib resistance; targeted therapy
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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