Sabbagh, H.A.K.; Hussein-Al-Ali, S.H.; Hussein, M.Z.; Abudayeh, Z.; Ayoub, R.; Abudoleh, S.M. A Statistical Study on the Development of Metronidazole-Chitosan-Alginate Nanocomposite Formulation Using the Full Factorial Design. Polymers 2020, 12, 772, doi:10.3390/polym12040772.
Sabbagh, H.A.K.; Hussein-Al-Ali, S.H.; Hussein, M.Z.; Abudayeh, Z.; Ayoub, R.; Abudoleh, S.M. A Statistical Study on the Development of Metronidazole-Chitosan-Alginate Nanocomposite Formulation Using the Full Factorial Design. Polymers 2020, 12, 772, doi:10.3390/polym12040772.
Sabbagh, H.A.K.; Hussein-Al-Ali, S.H.; Hussein, M.Z.; Abudayeh, Z.; Ayoub, R.; Abudoleh, S.M. A Statistical Study on the Development of Metronidazole-Chitosan-Alginate Nanocomposite Formulation Using the Full Factorial Design. Polymers 2020, 12, 772, doi:10.3390/polym12040772.
Sabbagh, H.A.K.; Hussein-Al-Ali, S.H.; Hussein, M.Z.; Abudayeh, Z.; Ayoub, R.; Abudoleh, S.M. A Statistical Study on the Development of Metronidazole-Chitosan-Alginate Nanocomposite Formulation Using the Full Factorial Design. Polymers 2020, 12, 772, doi:10.3390/polym12040772.
Abstract
The purpose of this study was to investigate the effect of chitosan (CS) and Alginate (Alg) polymers concentrations and CaCl2 concentration on metronidazole (MET) drug loading (LE), size particles and zeta potential. Nanocomposites were prepared by ionotropic pregelation method. A (21 *31 *21) *3= 36 full factorial design (FFD) was used to predict statistical equation and responses. The MET-CS-AlgNPs nanocomposites were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, thermal gravimetric analysis, scanning electron microscope and in vitro drug release studies. All data indicated the presence of drug into MET-CS-AlgNPs nanocomposites. The release profile of MET-CS-AlgNPs nanocomposites was found to be sustained
Keywords
Full Factorial Design; Optimization; metronidazole; nanocomposites; sodium alginate; Chitosan
Subject
Chemistry and Materials Science, Nanotechnology
Copyright:
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