Version 1
: Received: 7 March 2020 / Approved: 10 March 2020 / Online: 10 March 2020 (08:45:34 CET)
How to cite:
Feng, Z.; Wang, Y.; Qi, W. The Small Intestine, an Underestimated Site of SARS-CoV-2 Infection: From Red Queen Effect to Probiotics. Preprints2020, 2020030161. https://doi.org/10.20944/preprints202003.0161.v1
Feng, Z.; Wang, Y.; Qi, W. The Small Intestine, an Underestimated Site of SARS-CoV-2 Infection: From Red Queen Effect to Probiotics. Preprints 2020, 2020030161. https://doi.org/10.20944/preprints202003.0161.v1
Feng, Z.; Wang, Y.; Qi, W. The Small Intestine, an Underestimated Site of SARS-CoV-2 Infection: From Red Queen Effect to Probiotics. Preprints2020, 2020030161. https://doi.org/10.20944/preprints202003.0161.v1
APA Style
Feng, Z., Wang, Y., & Qi, W. (2020). The Small Intestine, an Underestimated Site of SARS-CoV-2 Infection: From Red Queen Effect to Probiotics. Preprints. https://doi.org/10.20944/preprints202003.0161.v1
Chicago/Turabian Style
Feng, Z., Yan Wang and Wei Qi. 2020 "The Small Intestine, an Underestimated Site of SARS-CoV-2 Infection: From Red Queen Effect to Probiotics" Preprints. https://doi.org/10.20944/preprints202003.0161.v1
Abstract
Understanding how the coronaviruses invade our body is an essential point, and the expression profile of coronaviruses receptor may help us to find where the coronavirus infects our body. We found that the coronavirus receptors, including angiotensin-converting enzyme 2 (ACE2) for SARS-CoV and SARS-Cov-2, are digestion-related enzymes in human enterocytes. Coronaviruses are continually altering the binding receptor and binding modes during their evolution, but the potential target cell in the small intestine is constant when in the lung is inconstant. Enterocytes may act as a conserved cell reservoir for coronaviruses, which may be partially explained by the Red Queen hypothesis. We also found that coronaviruses receptors could be elevated in the presence of both invasive bacteria and their counterpart, probiotics. We demonstrated here that enterocytes act as a conserved cell reservoir for coronaviruses during their evolutions, which should not be ignored in the investigation of coronavirus diagnosis and treatment strategies.
Keywords
coronaviruses receptors; angiotensin-converting enzyme 2 (ACE2); COVID-19; SARS-Cov-2; the Red Queen hypothesis; segmented filamentous bacteria
Subject
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Commenter: Dr Mounir Belkouch
The commenter has declared there is no conflict of interests.
It is very interesting the link beetween coronavirus and gut microbiota.
I think that it's important to evaluate Lactobacillus gasseri probiotic as a potential treatment against covid 19.
I am sure that it is specific. It could help to treat inflammation and respiratory disorders.
Sincerely tours
Dr Mounir Belkouch
Teacher in biochemistry, biology and microbiology.
Holder of a PhD in Neurosciences
The commenter has declared there is no conflict of interests.