North and West Africa are the most vulnerable regions to drought, due to the high variation in monthly precipitation. An accurate and efficient monitoring of drought is essential. In this study, we use TRMM data with remote sensing tools for effective monitoring of drought. The Drought Severity Index (DSI), Temperature Vegetation Drought Index (TVDI), Normalized Difference Vegetation Index (NDVI), and Normalized Vegetation Supply Water Index (NVSWI) are more useful for monitoring the drought over North and West Africa. To classify the areas affected by drought, we used the TRMM spatial maps to verify the TVDI, DSI and NVSWI indexes derived from MODIS. The DSI, TVDI, NVSWI and Monthly Precipitation Anomaly (NPA) indexes with the employ of MODIS-derived ET/PET and NDVI were chosen for monitoring the drought in the study area. The seasonal spatial correlation between the DSI, NPA, NVWSI, NDVI, TVDI and TCI indicates that NVSWI, NDVI and DSI present an excellent monitor of drought indexes. The change trend of drought from 2002 to 2018 was also characterized. The frequency of drought showed a decrease during this period.