Review
Version 2
This version is not peer-reviewed
Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs
Version 1
: Received: 6 April 2020 / Approved: 8 April 2020 / Online: 8 April 2020 (04:11:27 CEST)
Version 2 : Received: 8 April 2020 / Approved: 9 April 2020 / Online: 9 April 2020 (16:19:14 CEST)
Version 2 : Received: 8 April 2020 / Approved: 9 April 2020 / Online: 9 April 2020 (16:19:14 CEST)
A peer-reviewed article of this Preprint also exists.
Jacobson, K.A.; Reitman, M.L. Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs. Cells 2020, 9, 956. Jacobson, K.A.; Reitman, M.L. Adenosine-Related Mechanisms in Non-Adenosine Receptor Drugs. Cells 2020, 9, 956.
Abstract
Many ligands directly target adenosine receptors (ARs). Here we review the effects of noncanonical AR drugs on adenosinergic signaling. Non-AR mechanisms include raising adenosine levels by inhibiting adenosine transport (e.g. ticagrelor, ethanol, cannabidiol), affecting intracellular metabolic pathways (e.g. methotrexate, nicotinamide riboside, salicylate, 5‐aminoimidazole‐4‐carboxamide riboside), or undetermined means (e.g. acupuncture). Yet other compounds bind ARs in addition to their canonical ‘on-target’ activity (e.g. mefloquine). The strength of experimental support for an adenosine-related role in a drug’s effects varies widely. AR knockout mice are the ‘gold standard’ method for investigating an AR role, but few drugs have been tested in these mice. Given the interest in AR modulation for treatment of cancer, CNS, immune, metabolic, cardiovascular, and musculoskeletal conditions, it is informative to consider AR and non-AR adenosinergic effects of approved drugs and conventional treatments.
Keywords
adenosine receptor; nucleoside transport; CNS; inflammation; cardiovascular system; pain
Subject
Medicine and Pharmacology, Pharmacology and Toxicology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Commenter: Kenneth Jacobson
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