Version 1
: Received: 2 July 2020 / Approved: 3 July 2020 / Online: 3 July 2020 (09:05:13 CEST)
How to cite:
Gilani, S. A.; Imran, M.; Haq, I.-U.; Mehboob, R.; Fatima, W.; Hassan, A. Gambogic Acid as Anticancer Agent: A Review. Preprints2020, 2020070029. https://doi.org/10.20944/preprints202007.0029.v1
Gilani, S. A.; Imran, M.; Haq, I.-U.; Mehboob, R.; Fatima, W.; Hassan, A. Gambogic Acid as Anticancer Agent: A Review. Preprints 2020, 2020070029. https://doi.org/10.20944/preprints202007.0029.v1
Gilani, S. A.; Imran, M.; Haq, I.-U.; Mehboob, R.; Fatima, W.; Hassan, A. Gambogic Acid as Anticancer Agent: A Review. Preprints2020, 2020070029. https://doi.org/10.20944/preprints202007.0029.v1
APA Style
Gilani, S. A., Imran, M., Haq, I. U., Mehboob, R., Fatima, W., & Hassan, A. (2020). Gambogic Acid as Anticancer Agent: A Review. Preprints. https://doi.org/10.20944/preprints202007.0029.v1
Chicago/Turabian Style
Gilani, S. A., Wafa Fatima and Amber Hassan. 2020 "Gambogic Acid as Anticancer Agent: A Review" Preprints. https://doi.org/10.20944/preprints202007.0029.v1
Abstract
Gambogic acid, a common traditional Chinese medicine and widely distributed throughout South China, Vietnam, Cambodia, and Thailand. It is prenylated xanthone which is the significant bioactive compound of gamboge. Gambogic acid is known as a strong apoptotic inducer in cancer cells. It has been found as strong anticancer agent against various types of cancer cells lines such as breast cancer, pancreatic, and cervical cancer. It induces apoptosis, down regulates the anti-apoptotic proteins (survivin and BCL2,) and down regulates the activities of P-glycoprotein in drug sensitive human breast MCF-7 and drug-resistant MCF-7/ADR cells. Similarly, it also exerts alteration in P13K, AKT, p21, MMP-2 &-9, and phosphorylated-AKT expressions. The current review highlights the anticancer and chemo-preventive perspectives of gambogic acid and its mechanistic role against human and animal cancers.
Keywords
Gambogic acid; phytochemical; breast cancer; pancreatic cancer; glioma cancer
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.