Version 1
: Received: 2 September 2020 / Approved: 3 September 2020 / Online: 3 September 2020 (04:13:12 CEST)
How to cite:
Botelho, J.; Mascarenhas, P.; Mendes, J. J.; Machado, V. Network Protein Interaction in Parkinson's Disease and Periodontitis Interplay: A Bioinformatic Analysis. Preprints2020, 2020090050. https://doi.org/10.20944/preprints202009.0050.v1
Botelho, J.; Mascarenhas, P.; Mendes, J. J.; Machado, V. Network Protein Interaction in Parkinson's Disease and Periodontitis Interplay: A Bioinformatic Analysis. Preprints 2020, 2020090050. https://doi.org/10.20944/preprints202009.0050.v1
Botelho, J.; Mascarenhas, P.; Mendes, J. J.; Machado, V. Network Protein Interaction in Parkinson's Disease and Periodontitis Interplay: A Bioinformatic Analysis. Preprints2020, 2020090050. https://doi.org/10.20944/preprints202009.0050.v1
APA Style
Botelho, J., Mascarenhas, P., Mendes, J. J., & Machado, V. (2020). Network Protein Interaction in Parkinson's Disease and Periodontitis Interplay: A Bioinformatic Analysis. Preprints. https://doi.org/10.20944/preprints202009.0050.v1
Chicago/Turabian Style
Botelho, J., José João Mendes and Vanessa Machado. 2020 "Network Protein Interaction in Parkinson's Disease and Periodontitis Interplay: A Bioinformatic Analysis" Preprints. https://doi.org/10.20944/preprints202009.0050.v1
Abstract
Recent studies supported a clinical association between Parkinson’s Disease (PD) and periodontitis. Hence, investigating possible protein interactions between these two conditions is of interest. In this study, we conducted a protein-protein network interaction analysis with recognized genes encoding proteins for PD and periodontitis. Genes of interest were collected via GWAS database. Then, we conducted a protein interaction analysis using STRING database, with a highest confidence cut-off of 0.9. Our protein network casted a comprehensive analysis of potential protein-protein interactions between PD and periodontitis. This analysis may underpin valuable information for new candidate molecular mechanisms between PD and periodontitis and may serve new potential targets for research purposes. These results should be carefully interpreted giving the limitations of this approach.
Medicine and Pharmacology, Dentistry and Oral Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
