Version 1
: Received: 29 November 2020 / Approved: 1 December 2020 / Online: 1 December 2020 (14:08:33 CET)
How to cite:
Emmerich, F.; Zschiedrich, S.; Reichenbach-Braun, C.; Süsal, C.; Minguet, S.; Pauly, M.-C.; Seidl, M. Association of High Pre-Transplant Caveolin-1 Serum Concentrations with Attenuated Acute Cellular Rejection in Kidney Transplantation. Preprints2020, 2020120030
Emmerich, F.; Zschiedrich, S.; Reichenbach-Braun, C.; Süsal, C.; Minguet, S.; Pauly, M.-C.; Seidl, M. Association of High Pre-Transplant Caveolin-1 Serum Concentrations with Attenuated Acute Cellular Rejection in Kidney Transplantation. Preprints 2020, 2020120030
Emmerich, F.; Zschiedrich, S.; Reichenbach-Braun, C.; Süsal, C.; Minguet, S.; Pauly, M.-C.; Seidl, M. Association of High Pre-Transplant Caveolin-1 Serum Concentrations with Attenuated Acute Cellular Rejection in Kidney Transplantation. Preprints2020, 2020120030
APA Style
Emmerich, F., Zschiedrich, S., Reichenbach-Braun, C., Süsal, C., Minguet, S., Pauly, M. C., & Seidl, M. (2020). Association of High Pre-Transplant Caveolin-1 Serum Concentrations with Attenuated Acute Cellular Rejection in Kidney Transplantation. Preprints. https://doi.org/
Chicago/Turabian Style
Emmerich, F., Marie-Christin Pauly and Maximilian Seidl. 2020 "Association of High Pre-Transplant Caveolin-1 Serum Concentrations with Attenuated Acute Cellular Rejection in Kidney Transplantation" Preprints. https://doi.org/
Abstract
Acute and chronic transplant rejections due to alloreactivity are essential contributors to graft loss. However, the strength of alloreactivity is biased by non-immunological factors such as ischemia reperfusion injury (IRI). Accordingly, protection from IRI could be favorable in terms of limiting graft rejection. Caveolin-1 (Cav-1) is part of the cell membrane and an important regulator of intracellular signaling. Cav-1 has been demonstrated to limit IRI and to promote survival of a variety of cell types including renal cells under stress conditions. Accordingly, Cav-1 could also play a role in limiting anti-graft immune responses. Here, we evaluated a possible association between pretransplant serum concentrations of Cav-1 and the occurrence of rejection during follow up in a pilot study. Therefore, Cav-1-serum concentrations were analyzed in 91 patients at the time of kidney transplantation and compared to the incidence of acute and chronic rejection. Higher Cav-1 levels were associated with lower occurrence of acute rejection episodes. Moreover, Cav-1 could be therapeutically useful for attenuating graft rejection.
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