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An Orally Bioavailable (Mice) Prodrug of Glutathione
Version 1
: Received: 13 April 2021 / Approved: 14 April 2021 / Online: 14 April 2021 (11:40:14 CEST)
How to cite: Nagasawa, H. T.; Crankshaw, D. L.; Briggs, J. E.; Vince, R. An Orally Bioavailable (Mice) Prodrug of Glutathione. Preprints 2021, 2021040368. https://doi.org/10.20944/preprints202104.0368.v1 Nagasawa, H. T.; Crankshaw, D. L.; Briggs, J. E.; Vince, R. An Orally Bioavailable (Mice) Prodrug of Glutathione. Preprints 2021, 2021040368. https://doi.org/10.20944/preprints202104.0368.v1
Abstract
Cysteine-glutathione mixed disulfide (CySSG), a prodrug of glutathione (GSH) --the “Master Antioxidant”, was found to be orally bioavailable in mice, and protected against a toxic dose of acetaminophen. If oral bioavailability can also be demonstrated in humans, this suggests a wide range of applicability for CySSG.
Keywords
CySSG; prodrug; glutathione; orally; bioavailable
Subject
Chemistry and Materials Science, Medicinal Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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