Article
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Preserved in Portico This version is not peer-reviewed
Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides
Version 1
: Received: 13 August 2021 / Approved: 16 August 2021 / Online: 16 August 2021 (13:31:28 CEST)
A peer-reviewed article of this Preprint also exists.
Chen, R.; Xu, S.; Shen, F.; Xu, C.; Wang, K.; Wang, Z.; Liu, L. Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides. Molecules 2021, 26, 5551. Chen, R.; Xu, S.; Shen, F.; Xu, C.; Wang, K.; Wang, Z.; Liu, L. Facile Synthesis of Sulfonyl Chlorides/Bromides from Sulfonyl Hydrazides. Molecules 2021, 26, 5551.
Abstract
A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups has been described. A variety of nucleophiles could be engaged in this transformation thus permitting the synthesis of complex sulfonamides, sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products in excellent yields.
Keywords
Sulfonyl chlorides; sulfonyl bromides; sulfonyl hydrazides; NCS; NBS
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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