Akter, K.M.; Umar, B.U.; Rahman, S.N. Recent Updates on MicroRNA as Potential Biomarkers for Diagnosis of Gestational Diabetes Mellitus. Journal of Medicine 2022, 23, 146–150, doi:10.3329/jom.v23i2.60632.
Akter, K.M.; Umar, B.U.; Rahman, S.N. Recent Updates on MicroRNA as Potential Biomarkers for Diagnosis of Gestational Diabetes Mellitus. Journal of Medicine 2022, 23, 146–150, doi:10.3329/jom.v23i2.60632.
Akter, K.M.; Umar, B.U.; Rahman, S.N. Recent Updates on MicroRNA as Potential Biomarkers for Diagnosis of Gestational Diabetes Mellitus. Journal of Medicine 2022, 23, 146–150, doi:10.3329/jom.v23i2.60632.
Akter, K.M.; Umar, B.U.; Rahman, S.N. Recent Updates on MicroRNA as Potential Biomarkers for Diagnosis of Gestational Diabetes Mellitus. Journal of Medicine 2022, 23, 146–150, doi:10.3329/jom.v23i2.60632.
Abstract
Background/Aims: Screening for gestational diabetes mellitus (GDM) are currently done at 24 - 28 weeks of conception, missing out on the most vulnerable period of organogenesis and thus preventing clinicians from starting treatments until the late second or third trimester. MicroRNAs (miR) are small non-coding RNA molecules thatcould aid in detecting or predicting GDM through establishing a novel non-invasive prenatal testing (NIPT) tool. The objective of this study was to summarize the most recent updates on plasma microRNAs as GDM diagnostic biomarkers. Methods: Between April and June 2021, a PubMed literature search was undertaken to review recent articles on human plasma miR associated with GDM. Animal studies and papers that are written in languages other than English were excluded. Only plasma miRNAs were used to avoid coagulation biases. Results: A total of 31 miRNAs were found significantly upregulated in the plasma samples of patients with GDM. It was found mainly during the 2nd or 3rd trimester except for miR-223 and miR-23a that were upregulated at 9 – 11 weeks of gestation. Conclusion: Though extensive prospective cohort studies are required, miR-223 and miR-23a should be considered the most promising to develop a successful NIPT tool because they were found to be upregulated earliest, during the first trimester.
Keywords
microRNA; diabetes; pregnancy; prenatal testing
Subject
Medicine and Pharmacology, Obstetrics and Gynaecology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.