Cuccu, F.; Basoccu, F.; Fattuoni, C.; Porcheddu, A. N-Formylsaccharin: A Sweet(Able) Formylating Agent in Mechanochemistry. Molecules 2022, 27, 5450, doi:10.3390/molecules27175450.
Cuccu, F.; Basoccu, F.; Fattuoni, C.; Porcheddu, A. N-Formylsaccharin: A Sweet(Able) Formylating Agent in Mechanochemistry. Molecules 2022, 27, 5450, doi:10.3390/molecules27175450.
Cuccu, F.; Basoccu, F.; Fattuoni, C.; Porcheddu, A. N-Formylsaccharin: A Sweet(Able) Formylating Agent in Mechanochemistry. Molecules 2022, 27, 5450, doi:10.3390/molecules27175450.
Cuccu, F.; Basoccu, F.; Fattuoni, C.; Porcheddu, A. N-Formylsaccharin: A Sweet(Able) Formylating Agent in Mechanochemistry. Molecules 2022, 27, 5450, doi:10.3390/molecules27175450.
Abstract
The acylation of amines has always attracted a deep interest as a synthetic route due to its high versatility in organic chemistry and biochemical processes. The purpose of this article is to depict a mechanochemical acylation procedure based on the use of acyl-saccharin derivatives, namely N-formylsaccharin, N-acetylsaccharin and N-propionylsaccharin. This protocol furnishes a valuable solventless alternative to the existing processes and aims to be highly beneficial in multi-step procedures due to its rapid and user-friendly workup.
Chemistry and Materials Science, Organic Chemistry
Copyright:
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