Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Osteoporosis in Celiac Disease: An Update

Version 1 : Received: 22 July 2022 / Approved: 25 July 2022 / Online: 25 July 2022 (02:42:10 CEST)

How to cite: Lungaro, L.; Manza, F.; Costanzini, A.; caputo, F.; Zoli, G.; Volta, U.; De Giorgio, R.; Caio, G. Osteoporosis in Celiac Disease: An Update. Preprints 2022, 2022070344. https://doi.org/10.20944/preprints202207.0344.v1 Lungaro, L.; Manza, F.; Costanzini, A.; caputo, F.; Zoli, G.; Volta, U.; De Giorgio, R.; Caio, G. Osteoporosis in Celiac Disease: An Update. Preprints 2022, 2022070344. https://doi.org/10.20944/preprints202207.0344.v1

Abstract

Celiac disease (CD) is an autoimmune disorder triggered by gluten ingestion in genetically predisposed individuals. In addition to the typical gastrointestinal symptoms such as diarrhea, bloating, or chronic abdominal pain, CD may also present a wide spectrum of manifestations, including low bone mineral density (BMD) and osteoporosis. This review aims to describe the role of CD in the development of skeletal alterations, underlying important clinical aspects and therapeutic implications. The etiopathology of bone lesions in CD is multifactorial and their management is challenging. Here, we provide gastroenterologists and orthopedics with an up-to-date overview on the link between CD and osteoporosis to improve the management of the CD condition.

Keywords

celiac disease; osteoporosis; osteopenia; bone mass density; malabsorption; calcium; vitamin D

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

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